Repair of a Damaged Cornea Using Cells Derived from Induced Pluripotent Stem Cells
Since the discovery of induced pluripotency more than a decade ago, researchers have been working towards the use of this technology to produce cells for use in tissue engineering and regenerative therapies. Induced pluripotent stem cells are functionally equivalent to embryonic stem cells; given suitable recipes and methods for the surrounding environment and signals, they can be made to generate any of the cell types in the body. The cornea of the eye is a comparatively simple starting point for tissue engineering, easier to work with in many ways, in generating tissues and in delivering cells to the patient. Here, the f...
Source: Fight Aging! - September 12, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 17th 2019
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductase activiti...
Source: Fight Aging! - June 16, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Bioprinted Corneas
While no tissues can be said to be simple, some are simpler than others. In the past decade, tissue engineers have made considerable progress towards the manufacture of these simpler tissues, from the starting point of cells and scaffold materials. Bioprinting, a form of rapid prototyping, has proven to be an important class of approach. The research noted here is a representative example of progress towards the production of corneas to replace those that are damaged by accident or age, and thus eliminate the need for donor tissue.
When a person has a severely damaged cornea, a corneal transplant is required. For ...
Source: Fight Aging! - June 13, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Dry Eye: An Interview With Corneal Specialist Dr. Peter Polack
I met ophthalmologist and corneal specialist Dr. Peter Polack while speaking in Ocala, Florida. He told me that, by having his patients with dry eye—which has increased dramatically over the last 20 years—remove all wheat and grains, he is seeing this condition reverse within weeks, along with all the other health benefits.
Unlike other ophthalmologists, who virtually have nothing to do with diet and therefore prescribe the costly drugs Restasis and Xiidra (each cost $500-$550 per month), Dr. Polack rarely has to resort to use of these awful agents.
Here Dr. Polack speaks about his phenomenal experience.
More a...
Source: Wheat Belly Blog - July 20, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates autoimmune dry eye gluten-free grain-free grains Inflammation restasis undoctored wheat belly xiidra Source Type: blogs
Interesting things about traveling
He had a very hard time adjusting to altitude changes. I thought that was interesting. The higher the altitude, the more nitroglycerin he took and the more difficulty he had breathing. I don't think either of us were prepared for that.Temperature changes affected him as well. If he got cold, he put on gloves....and I'd be so hot I'd have the AC on blast!Almost a comedy of errors. He worried constantly about having enough insulin. I reassured him that we were never more than 3 or 4 days from home and could start back any time he wanted.We were gone almost a month. I loved every moment of ...
Source: Wife of a Diabetic - March 9, 2018 Category: Endocrinology Source Type: blogs
Better Understanding how Cell Therapy can Clear a Scarred Cornea
Researchers here make some progress in understanding how stem cell therapies can reduce scarring in a damaged cornea. While focused on injuries rather than age-related damage, this should hopefully still speed progress towards better therapies for a range of conditions that cause blindness through opaque corneal scarring. That the mechanism is keyed to inflammation may also explain why some other approaches known to reduce levels of inflammation, such as those involving mitochondrially targeted antioxidants, are effective.
In cases of severe ocular trauma involving the cornea, wound healing occurs following interv...
Source: Fight Aging! - October 3, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
