GeneXpert or chest-X-ray or tuberculin skin testing for household contact assessment (GXT): protocol for a cluster-randomized trial
DiscussionThis randomized trial is meant to provide high-quality evidence to inform WHO recommendations on investigation of household contacts, as currently these are based on very low-quality evidence.Trial registrationClinicalTrials.gov NCT04528823. (Source: Trials)
Source: Trials - August 2, 2022 Category: Research Source Type: clinical trials
New Insights into HIV Latent Cells Yield Potential Cure Targets
July 27, 2022 -- In a presentation today at AIDS 2022, the 24th International AIDS Conference in Montreal, scientists with the National Institute of Allergy and Infectious Diseases’ (NIAID) Vaccine Research Center (VRC) and their collaborators... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - July 27, 2022 Category: Pharmaceuticals Source Type: clinical trials
Saniona ’s preclinical candidate SAN903 shows robust dampening of fibrosis in Chronic Kidney Disease model
Denmark, June 24, 2022 - Saniona a clinical stage biopharmaceutical company, today announced that professor Helle Prætorius, Univ. of Aarhus, Denmark, made a presentation at the ECM conference, 2022, which shows that SAN903 protects... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - June 24, 2022 Category: Pharmaceuticals Source Type: clinical trials
Protocol paper: multi-Centre randomised controlled trial evaluating a pre-clinic diabetes assessment and mapped care planning intervention amongst adults with type 1, type 2 or pre-diabetes
DiscussionResults from the study will provide valuable insights into patient-professional communication practices within routine care and recommendations will be made, as necessary, for improvements to that. If the intervention is shown to be clinically and cost-effective, the feedback from participants and healthcare professionals will be used to make any improvements prior to its deployment to support improved communication and associated health outcomes.Ethics and disseminationThe trial was approved by the Wales REC7 Research Ethics Committee (21/WA/0020). Results will be disseminated through national and international ...
Source: Trials - June 20, 2022 Category: Research Source Type: clinical trials
The effect of a probiotic on gastrointestinal symptoms due to menstruation in healthy adult women on oral contraceptives: randomized, double-blind, placebo-controlled trial protocol
This study evaluates the effect of a probiotic on abdominal pain and gastrointestinal symptoms in healthy women who take an oral contraceptive, have regular menses, and typically experience these symptoms during menstruation with the primary aim being change in abdominal pain intensity related to the menstrual cycle with probiotic versus placebo supplementation.Methods and analysisIn this randomized, double-blind, placebo-controlled parallel study, participants will receive either a probiotic or placebo supplement. Participants will begin answering questionnaires approximately 7 days before the start of menstruation (i....
Source: Trials - June 10, 2022 Category: Research Source Type: clinical trials
Tolerating bad health research: the continuing scandal
ConclusionsMost randomised trials are bad and most trial participants will be in one. The research community has tolerated this for decades. This has to stop: we need to put rigour and methodology where it belongs — at the centre of our science. (Source: Trials)
Source: Trials - June 2, 2022 Category: Research Source Type: clinical trials
The Effects of Observer Presence and Type on Patients' Perception of Exercise After Bone Tumor Resection-A Qualitative Study
Conditions: Bone Cancer; Tumor Interventions: Other: Supervised Exercise by a physiotherapist via face to face; Other: Supervised Exercise by a physiotherapist via video conference Sponsor: Istanbul Medeniyet University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 31, 2022 Category: Research Source Type: clinical trials
Are preoperative oral antibiotics effective in reducing the incidence of anastomotic leakage after colorectal cancer surgery? Study protocol for a prospective, multicentre, randomized controlled study
This study will examine whether oral antibiotic bowel preparation (OABP) influences the incidence of anastomotic leakage after surgery in a prospective, multicentre, randomized controlled trial that will enrol 1500 patients who require colon surgery. The primary endpoint, incidence of anastomotic leakage, is based on 2.3% in the OABP ± mechanical bowel preparation (MBP) group in the study by Morris et al. Patients will be randomized (1:1) into two groups: the test group will be given antibiotics (both neomycin 1 g and metronidazole 0.9 g) the day before surgery, and the control group will not receive any special intes...
Source: Trials - May 23, 2022 Category: Research Source Type: clinical trials
