Detailed statistical analysis plan for the SafeBoosC III trial: a multinational randomised clinical trial assessing treatment guided by cerebral oxygenation monitoring versus treatment as usual in extremely preterm infants
This article describes the detailed statistical analysis plan for the main publication, with the aim to prevent outcome reporting bias and data-driven analyses.Methods/designThe SafeBoosC III trial is an investigator-initiated, randomised, multinational, pragmatic phase III trial with a parallel group structure, designed to investigate the benefits and harms of treatment based on cerebral near-infrared spectroscopy monitoring compared with treatment as usual. Randomisation will be 1:1 stratified for neonatal intensive care unit and gestational age (lower gestational age (< 26 weeks) compared to higher gestational a...
Source: Trials - December 18, 2019 Category: Research Source Type: clinical trials
A multicentre parallel-group randomised trial assessing multiparametric MRI characterisation and image-guided biopsy of prostate in men suspected of having prostate cancer: MULTIPROS study protocol
DiscussionThe primary objective is to determine whether mpMRI can improve PCa detection and characterisation. The key secondary objective is to determine whether MRI/US fusion-guided biopsy can reduce the number of false-negative biopsies. Ethical approval was obtained from the East of Scotland Research Ethics Committee 1 (14/ES/1070) on 20 November 2014. The results of this study will be used for publication and presentation in national and international journals and at scientific conferences.Trial registrationClinicalTrials.gov,NCT02745496. Retrospectively registered on 20 April 2016. (Source: Trials)
Source: Trials - November 20, 2019 Category: Research Source Type: clinical trials
Boehringer Ingelheim Advances First Pan-KRAS Inhibitor BI 1701963 into Clinical Testing
Ingelheim, Germany, 29 October 2019 – Boehringer Ingelheim today presented promising preclinical data from its pan-KRAS program including the novel, oral inhibitor BI 1701963 at the AACR-NCI-EORTC International Conference on Molecular... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 29, 2019 Category: Pharmaceuticals Source Type: clinical trials
Meeting abstracts from the 5th International Clinical Trials Methodology Conference (ICTMC 2019)
(Source: Trials)
Source: Trials - October 21, 2019 Category: Research Source Type: clinical trials
Visio-conference for Pre-hospital Triage of Stroke Suspicions
Conditions: Stroke; Stroke, Acute; Stroke, Ischemic; Cerebrovascular Disorders Intervention: Procedure: Visio conference device evaluation (DVCM) Sponsor: University Hospital, Bordeaux Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 2, 2019 Category: Research Source Type: clinical trials
