Performance feedback on the quality of care in hospitals performing thrombectomy for ischemic stroke (PERFEQTOS): protocol of a stepped wedge cluster randomized trial
This study will provide evidence on the effectiveness of performance feedback to healthcare providers. The results will be actively disseminated through peer-reviewed journals, conference presentations, and various stakeholder engagement activities.Trial registrationNetherlands Trial RegisterNL9090. Registered on December 3, 2020 (Source: Trials)
Source: Trials - December 4, 2021 Category: Research Source Type: clinical trials
Rationale and design of the 2 by 2 factorial design GnG-trial: a randomized phase-III study to compare two schedules of gemtuzumab ozogamicin as adjunct to intensive induction therapy and to compare double-blinded intensive postremission therapy with or without glasdegib in older patients with newly diagnosed AML
AbstractBackgroundOverall survival remains poor in older patients with acute myeloid leukemia (AML) with less than 10% being alive after 5 years. In recent studies, a significant improvement in event-free, relapse-free and overall survival was shown by adding gemtuzumab ozogamicin (GO), a humanized antibody-drug conjugate directed against CD33, to intensive induction therapy once or in a sequential dosing schedule. Glasdegib, the small-molecule inhibitor of smoothened (SMO), also showed improved overall survival in patients not eligible for intensive chemotherapy when combined with low-dose cytarabine compared to low-dose ...
Source: Trials - November 3, 2021 Category: Research Source Type: clinical trials
Effect of hydrogen gas inhalation on patient QOL after hepatectomy: protocol for a randomized controlled trial
This study is a randomized, controlled, double-blind superiority trial, which will be conducted as a “specified clinical trial” in accordance with the Clinical Trials Act in Japan. Trial registration was prospectively completed before the first participant was enrolled.The subjects will be patients who will undergo hepatectomy and will be allocated randomly into group A with hydrogen gas inhalation or group B with air inhalation after hepatectomy. The study will examine if hydrogen gas inhalation improves QOL of post-hepatectomy patients. The primary endpoint is patient QOL (score of a 40-item quality of recovery quest...
Source: Trials - October 21, 2021 Category: Research Source Type: clinical trials
A randomized controlled trial of an Internet-based emotion regulation intervention for sexual health: study protocol
AbstractIntroductionEmotion regulation difficulties have been associated with mental disorders and sexual dysfunctions. Traditional face-to-face transdiagnostic emotion regulation interventions have shown positive results for emotional and personality disorders. Only recently have the effects of these interventions on sexual health started to be investigated. Internet-delivered psychological interventions have several advantages over face-to-face interventions, such as cost-effectiveness, accessibility, and suitability for people who experience shame because of their stigmatized problematic behaviors and those who avoid se...
Source: Trials - October 15, 2021 Category: Research Source Type: clinical trials
The impact of frailty Screening of Older adults with muLtidisciplinary assessment of those At Risk during emergency hospital attendance on the quality, safety and cost-effectiveness of care (SOLAR): a randomised controlled trial.
AbstractBackgroundOlder people account for 25% of all Emergency Department (ED) admissions. This is expected to rise with an ageing demographic. Older people often present to the ED with complex medical needs in the setting of multiple comorbidities. Comprehensive Geriatric Assessment (CGA) has been shown to improve outcomes in an inpatient setting but clear evidence of benefit in the ED setting has not been established. It is not feasible to offer this resource-intensive assessment to all older adults in a timely fashion. Screening tools for frailty have been used to identify those at most risk for adverse outcomes follow...
Source: Trials - August 31, 2021 Category: Research Source Type: clinical trials
The role of machine learning in clinical research: transforming the future of evidence generation
ConclusionsML holds great promise for improving the efficiency and quality of clinical research, but substantial barriers remain, the surmounting of which will require addressing significant gaps in evidence. (Source: Trials)
Source: Trials - August 16, 2021 Category: Research Source Type: clinical trials
Lilly Releases Donanemab Data That Demonstrated Relationship Between Reduction of Amyloid Plaque and Slowing of Cognitive Decline
INDIANAPOLIS, July 29, 2021 /PRNewswire/ -- Today at the Alzheimer ' s Association International Conference© (AAIC© 2021), Eli Lilly and Company (NYSE: LLY) presented two new exploratory analyses of data from the... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - July 29, 2021 Category: Pharmaceuticals Source Type: clinical trials
The efficacy of Tuina with herbal ointment for patients with post-stroke depression: study protocol for a randomized controlled trial
This study may evaluate clinical application value and safety of Tuina with herbal ointment in PSD patients, which can provide basis for clinical research and mechanism exploration of PSD.Trial registrationChinese Clinical Trial RegistryChiCTR2000033887. Registered on 15 June 2020.DisseminationThe results will be published in peer-reviewed journals and disseminated through the study ’s website and conferences. (Source: Trials)
Source: Trials - July 28, 2021 Category: Research Source Type: clinical trials
Detailed statistical analysis plan for the short-term versus long-term mentalisation-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder randomised clinical trial (MBT-RCT)
DiscussionWe have developed this statistical analysis plan before unblinding of the trial results in line with the Declaration of Helsinki and the International Conference on Harmonization of Good Clinical Practice Guidelines, which should increase the validity of the MBT-RCT trial by mitigation of analysis bias.Trial registrationClinicalTrials.govNCT03677037. Registered on 19 September 2018 (Source: Trials)
Source: Trials - July 28, 2021 Category: Research Source Type: clinical trials
Evaluation of the Sanitary Safety of a Healthcare Professional Conference Held 9-11 June 2021 in Paris
Condition: Covid19 Intervention: Other: Exposure to the FICS annual meeting (June 9-11 2021, Paris Congress Center) Sponsor: French Society for Intensive Care Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 8, 2021 Category: Research Source Type: clinical trials
