Topical glucocorticoid application causing iatrogenic Cushing ’s syndrome followed by secondary adrenal insufficiency in infants: two case reports
We present a 6-month-old Syrian boy with cushingoid face after dermal clobetasol cream treatment and a 2-year-old Iranian girl with severe growth retardation after application of dexamethasone eye drops. Both families have a migration background and language barriers. In both cases no endogenous cortisol secretion was initially detected in serum and in 24-hour collected urine. After dose reduction of glucocorticoids, severity of symptoms was reversible and serum cortisol was detectable.Discussion and conclusionYoung infants are at high risk of developing Cushing ’s syndrome from topically applied highly potent glucocorti...
Source: Journal of Medical Case Reports - December 8, 2022 Category: General Medicine Source Type: research
Topological Indices of Novel Drugs Used in Autoimmune Disease Vitiligo Treatment and Its QSPR Modeling
In this study, topological indices (TIs) imposed on said drugs were found to have a good correlation with physicochemical properties in this course. Finally, this work can be helpful to design and synthesize new vitiligo treatments and other disease drugs.PMID:36425334 | PMC:PMC9681541 | DOI:10.1155/2022/6045066 (Source: Biomed Res)
Source: Biomed Res - November 25, 2022 Category: Research Authors: Saima Parveen Nadeem Ul Hassan Awan Fozia Bashir Farooq Rakotondrajao Fanja Qurat Ul Ain Anjum Source Type: research
