Correction to: Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study
AAPS PharmSciTech. 2024 Apr 18;25(5):87. doi: 10.1208/s12249-024-02795-w.NO ABSTRACTPMID:38637409 | DOI:10.1208/s12249-024-02795-w (Source: AAPS PharmSciTech)
Source: AAPS PharmSciTech - April 18, 2024 Category: Drugs & Pharmacology Authors: William W van Osdol Jasmina Novakovic Maxime Le Merdy Eleftheria Tsakalozou Priyanka Ghosh Jessica Spires Viera Lukacova Source Type: research
Maximum burn prevention practice versus conventional care after direct current cardioversion treatment: The BURN-PREVENTION trial
Development of cutaneous burns at the site of electrode placement is a known complication of the direct current (DC) cardioversion for atrial arrhythmias. While local cooling has been shown to mitigate burns,1 the effectiveness of weaker corticosteroid such as betamethasone has been less promising.2 This BURN-PREVENTION trial, a single-center, prospective, randomized, investigator-initiated, superiority trial, aimed to evaluate the efficacy of combining local cold application with clobetasol, a potent corticosteroid ointment, in preventing skin burns post-cardioversion. (Source: Heart Rhythm)
Source: Heart Rhythm - April 8, 2024 Category: Cardiology Authors: Reina Tonegawa-Kuji, Kenichiro Yamagata, Koshiro Kanaoka, Akinori Wakamiya, Yuko Y. Inoue, Koji Miyamoto, Yoshihiro Miyamoto, Eiji Kiyohara, Kengo Kusano Source Type: research
Use of Topical Corticosteroids in the Treatment of Noninfectious Inflammatory Dermatoses of the Scalp: A Survey of Practicing Dermatologists and Dermatology Residents Using Delphi Methodology
CONCLUSION: Clobetasol propionate was the preferred topical treatment for the management of scalp dermatoses, usually as first-line treatment; solution was the preferred preparation.PMID:38524395 | PMC:PMC10959751 | DOI:10.2147/CCID.S448016 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - March 25, 2024 Category: Dermatology Authors: Juan Francisco Mir-Bonaf é Jaime Piquero-Casals Ludmila Prudkin Jesus Delgado Julia Santamaria Mart ínez Vicente Garcia-Patos Briones Source Type: research
Platelet-rich plasma as a new and successful treatment for lichen planopilaris: A controlled blinded randomized clinical trial
CONCLUSION: Given the different efficacy profiles, PRP could be considered a new and effective choice for the treatment of LPP.PMID:38525908 | DOI:10.1111/jocd.16302 (Source: Pain Physician)
Source: Pain Physician - March 25, 2024 Category: Anesthesiology Authors: Elham Behrangi Amirhossein Akbarzadehpasha Abbas Dehghani Sona Zare Mohammadreza Ghassemi Roya Zeinali Azadeh Goodarzi Zahra Lotfi Source Type: research
Use of Topical Corticosteroids in the Treatment of Noninfectious Inflammatory Dermatoses of the Scalp: A Survey of Practicing Dermatologists and Dermatology Residents Using Delphi Methodology
CONCLUSION: Clobetasol propionate was the preferred topical treatment for the management of scalp dermatoses, usually as first-line treatment; solution was the preferred preparation.PMID:38524395 | PMC:PMC10959751 | DOI:10.2147/CCID.S448016 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - March 25, 2024 Category: Dermatology Authors: Juan Francisco Mir-Bonaf é Jaime Piquero-Casals Ludmila Prudkin Jesus Delgado Julia Santamaria Mart ínez Vicente Garcia-Patos Briones Source Type: research
Platelet-rich plasma as a new and successful treatment for lichen planopilaris: A controlled blinded randomized clinical trial
CONCLUSION: Given the different efficacy profiles, PRP could be considered a new and effective choice for the treatment of LPP.PMID:38525908 | DOI:10.1111/jocd.16302 (Source: Pain Physician)
Source: Pain Physician - March 25, 2024 Category: Anesthesiology Authors: Elham Behrangi Amirhossein Akbarzadehpasha Abbas Dehghani Sona Zare Mohammadreza Ghassemi Roya Zeinali Azadeh Goodarzi Zahra Lotfi Source Type: research
Platelet-rich plasma as a new and successful treatment for lichen planopilaris: A controlled blinded randomized clinical trial
CONCLUSION: Given the different efficacy profiles, PRP could be considered a new and effective choice for the treatment of LPP.PMID:38525908 | DOI:10.1111/jocd.16302 (Source: Pain Physician)
Source: Pain Physician - March 25, 2024 Category: Anesthesiology Authors: Elham Behrangi Amirhossein Akbarzadehpasha Abbas Dehghani Sona Zare Mohammadreza Ghassemi Roya Zeinali Azadeh Goodarzi Zahra Lotfi Source Type: research
Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis
Acta Pharmacol Sin. 2024 Mar 13. doi: 10.1038/s41401-024-01233-8. Online ahead of print.ABSTRACTCombining radiotherapy with Nrf-2 inhibitor holds promise as a potential therapeutic strategy for radioresistant lung cancer. Here, the radiosensitizing efficacy of a synthetic glucocorticoid clobetasol propionate (CP) in A549 human lung cancer cells was evaluated. CP exhibited potent radiosensitization in lung cancer cells via inhibition of Nrf-2 pathway, leading to elevation of oxidative stress. Transcriptomic studies revealed significant modulation of pathways related to ferroptosis, fatty acid and glutathione metabolism. Con...
Source: Acta Pharmacologica Sinica - March 14, 2024 Category: Drugs & Pharmacology Authors: Archita Rai Raghavendra S Patwardhan Sundarraj Jayakumar Pradnya Pachpatil Dhruv Das Girish Ch Panigrahi Vikram Gota Sejal Patwardhan Santosh K Sandur Source Type: research
Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis
Acta Pharmacol Sin. 2024 Mar 13. doi: 10.1038/s41401-024-01233-8. Online ahead of print.ABSTRACTCombining radiotherapy with Nrf-2 inhibitor holds promise as a potential therapeutic strategy for radioresistant lung cancer. Here, the radiosensitizing efficacy of a synthetic glucocorticoid clobetasol propionate (CP) in A549 human lung cancer cells was evaluated. CP exhibited potent radiosensitization in lung cancer cells via inhibition of Nrf-2 pathway, leading to elevation of oxidative stress. Transcriptomic studies revealed significant modulation of pathways related to ferroptosis, fatty acid and glutathione metabolism. Con...
Source: Acta Pharmacologica Sinica - March 14, 2024 Category: Drugs & Pharmacology Authors: Archita Rai Raghavendra S Patwardhan Sundarraj Jayakumar Pradnya Pachpatil Dhruv Das Girish Ch Panigrahi Vikram Gota Sejal Patwardhan Santosh K Sandur Source Type: research
Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis
Acta Pharmacol Sin. 2024 Mar 13. doi: 10.1038/s41401-024-01233-8. Online ahead of print.ABSTRACTCombining radiotherapy with Nrf-2 inhibitor holds promise as a potential therapeutic strategy for radioresistant lung cancer. Here, the radiosensitizing efficacy of a synthetic glucocorticoid clobetasol propionate (CP) in A549 human lung cancer cells was evaluated. CP exhibited potent radiosensitization in lung cancer cells via inhibition of Nrf-2 pathway, leading to elevation of oxidative stress. Transcriptomic studies revealed significant modulation of pathways related to ferroptosis, fatty acid and glutathione metabolism. Con...
Source: Acta Pharmacologica Sinica - March 14, 2024 Category: Drugs & Pharmacology Authors: Archita Rai Raghavendra S Patwardhan Sundarraj Jayakumar Pradnya Pachpatil Dhruv Das Girish Ch Panigrahi Vikram Gota Sejal Patwardhan Santosh K Sandur Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
Anti-laminin 332 antibodies in graft-versus-host disease-associated bullous pemphigoid after allogeneic peripheral blood stem cell transplantation
We report a 48-year-old woman with bullous pemphigoid (BP) with antibodies against the B3 subunit of laminin 332 after the development of graft-versus-host disease (GVHD). She was diagnosed with recurrent acute lymphoblastic leukemia at 40 years of age and underwent two rounds of allogeneic peripheral blood stem cell transplantations (PBST). Two and a half years after the second PBST, multiple tense blisters appeared on her face, hands, and lower legs. The diagnosis of BP was based on hematoxylin eosin and immunofluorescence staining and immunoblotting analyses. A combination regimen of topical corticosteroids (clobetasol ...
Source: Dermatol Online J - March 13, 2024 Category: Dermatology Authors: Yasutoshi Hida Riho Kageji Hirofumi Bekku Norito Ishii Source Type: research
