09: A randomized controlled trial of clobetasol propionate versus fractionated CO2 laser for the treatment of lichen sclerosus (CURLS)
To compare six month safety and efficacy outcomes of fractionated CO2 laser (laser) to topical clobetasol propionate (steroid) for treatment of symptomatic vulvar lichen sclerosus. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 28, 2020 Category: OBGYN Authors: L. Burkett, M. Siddique, A. Zeymo, R.E. Gutman, A.J. Park, C. Iglesia Tags: Oral Presentation Source Type: research

Psoriasis improvement and satisfaction in patients utilizing a clobetasol spray and oral apremilast combination regimen- a pilot study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 20, 2020 Category: Dermatology Authors: Chapman Wei, Adam J. Friedman, Ronald B. Prussick Source Type: research

Comparison of topical clobetasol propionate 0.05% and topical tacrolimus 0.1% in the treatment of cutaneous lichen planus.
Authors: Özkur E, Aksu EK, Gürel MS, Savaş S Abstract Introduction: The effectiveness of topical tacrolimus in the treatment of oral and genital lichen planus has been verified in many randomized studies; however, there are only few case reports in treatment of cutaneous lichen planus (CLP). Aim: We sought to compare the safety and efficacy of topical clobetasol propionate and tacrolimus ointment in the treatment of CLP. Material and methods: Retrospective analysis of patient files was performed. We enrolled patients who were diagnosed with CLP and treated with topical tacrolimus 0.1% or topical ...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Clobetasol/clobetasone overdose
(Source: Reactions Weekly)
Source: Reactions Weekly - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Unbearable wearables
As wearable devices play an increasing role in the management of health and disease, adverse skin reactions to wearables have become more common. However, the management of allergic contact dermatitis is challenging and new treatment options more compatible with wearable devices are needed. In a 40-year-old woman with contact dermatitis to a continuous glucose monitoring device, topical clobetasol propionate 0.05% spray proved to be an effective treatment that was compatible with the application of adhesive wearables. This case demonstrates that spray formulations of topical steroids are a good option for the treatment of ...
Source: Dermatology Online Journal - January 29, 2020 Category: Dermatology Source Type: research

[ASAP] Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02067 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - January 22, 2020 Category: Chemistry Authors: William C. Wright †‡, Jude Chenge†, Jingheng Wang†, Hazel M. Girvan§, Lei Yang†, Sergio C. Chai†, Andrew D. Huber†, Jing Wu†, Peter O. Oladimeji†, Andrew W. Munro§, and Taosheng Chen*† Source Type: research

Iontophoretic delivery of methotrexate in the treatment of palmar psoriasis: A randomised controlled study.
CONCLUSION: Iontophoretic delivery of methotrexate is a promising therapeutic modality, the efficacy of which is comparable to that of clobetasol propionate ointment in the treatment of palmar psoriasis. PMID: 31944270 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - January 16, 2020 Category: Dermatology Authors: Andanooru Chandrappa NK, Channakeshavaiah Ravikumar B, Rangegowda SM Tags: Australas J Dermatol Source Type: research

17 β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish.
17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Environ Pollut. 2019 Dec 18;259:113808 Authors: Schmid S, Fent K Abstract Fish are exposed to estrogens, progestins and glucocorticoids in the aquatic environment but effects on the blood coagulation cascade are unknown. Here we analyzed effects of 17β-estradiol (E2) alone and in combination with mixtures of new generation progestins and the glucocorticoid clobetasol propionate (CLO) in zebrafish embryos to assess their effects on the blood coagulation system. We assessed transcripts...
Source: Environmental Pollution - December 18, 2019 Category: Environmental Health Authors: Schmid S, Fent K Tags: Environ Pollut Source Type: research

Localized carbon dioxide laser treatment of a recalcitrant oral ulceration in pemphigus vulgaris
ConclusionsAdjunctive procedures that can facilitate a decrease in the cumulative dosages of corticosteroids and immunosuppressants have great value in the management of PV. CO2 laser vaporization is a safe procedure with minimal morbidity and no long-term side effects and should be considered as an adjunctive treatment option for management of recalcitrant lesions in patients with oral PV. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

A rare case of non-Langerhans cell histiocytosis/ Erdheim-Chester disease presenting as desquamative gingivitis and oral mucosal erythema
ConclusionsThis is the first report of potential oral mucosal involvement of ECD, with the noted desquamative gingivitis and erythema as its oral presentation. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Treatment of oral chronic graft-vs-host disease with clobetasol: case report
Graft-vs-host disease (GVHD) is the main complication of allogeneic hematopoietic stem cells transplantation. A 29-year-old Brazilian man was diagnosed as having severe aplastic anemia and submitted to allogeneic HSCT in October 2013. He developed systemic chronic GVHD, including the oral cavity (lichenoid lesions in right and left buccal mucosa and labial hyperchromia and was treated with mycophenolate mofetil, tacrolimus, cyclosporine, and dexamethasone solution [mouthwash]). Upon stabilization of chronic GVHD in the oral cavity, the patient displayed gingival atrophy and erythema (12-21/33-42) on July 27, 2017. (Source:...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: BARBARA BARRETO PACHECO VALENTIM, GABRIELA DE ASSIS RAMOS, CAMILA BRAND ÃO LOBO, TAÍSA DOMINGUES BERNARDES SILVA, HELITON SPINDOLA ANTUNES Source Type: research

Diagnosis of lupus erythematosus by oral lesions: case report
A 49-year-old white female patient presented bilateral white plaques on the buccal mucosa and lateral border of tongue with erythematous background, which was asymptomatic. On anamnesis, the patient reported bald patches in the midscalp region. The oral lesions were treated with 0.05% aqueous clobetasol solution for 15 days without significant improvement. The clobetasol concentration was increased to 0.1% for a further 15 days without significant improvement of the lesions. All treatments were suspended for 15 days, and a biopsy was proposed. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: YURI KALININ, SUELLEN VIEIRA DO NASCIMENTO, CL ÁUDIA PEREZ TRINDADE FRAGA, NARA MARIA VASCONCELOS IELO, LUCYENE MIGUITA LUIZ, MARCELO MARCUCCI Source Type: research

Unbearable wearables.
Abstract As wearable devices play an increasing role in the management of health and disease, adverse skin reactions to wearables have become more common. However, the management of allergic contact dermatitis is challenging and new treatment options more compatible with wearable devices are needed. In a 40-year-old woman with contact dermatitis to a continuous glucose monitoring device, topical clobetasol propionate 0.05% spray proved to be an effective treatment that was compatible with the application of adhesive wearables. This case demonstrates that spray formulations of topical steroids are a good option for...
Source: Dermatol Online J - December 15, 2019 Category: Dermatology Authors: Wei JJ, Hayward EM, Leung TH, Rosenbach M Tags: Dermatol Online J Source Type: research

Effects of the glucocorticoid clobetasol propionate and its mixture with cortisol and different class steroids in adult female zebrafish
Publication date: Available online 23 November 2019Source: Aquatic ToxicologyAuthor(s): Susanne Faltermann, Timm Hettich, Noemi Küng, Karl FentAbstractEcotoxicological effects of glucocorticoids and steroid mixtures in the environment are not sufficiently known. Here we investigate effects of 11-14 days exposure of female zebrafish to the glucocorticoid clobetasol propionate (Clo), cortisol (Cs), their mixture and mixtures with five different class steroids (Clo + triamcinolone + estradiol + androstendione + progesterone) in liver, brain and gonads. Cs showed lit...
Source: Aquatic Toxicology - November 25, 2019 Category: Toxicology Source Type: research

The comparison of therapeutic effect of Clobetasol propionate lotion and squill extract in alopecia areata: a randomized, double-blind clinical trial
AbstractAlopecia areata is a chronic inflammatory disease that characterized by round or oval patches of non-scarring hair loss. From the past,Urginea maritima (white squill) was used for the treatment of hair loss in Iranian traditional medicine. We aimed the comparison of Clobetasol lotion and squill extract efficacy in treatment of alopecia areata in a randomized, double-blind clinical trial. The 42 patients were randomized into two groups. Both groups received topical squill and clobetasol lotion twice daily lotion for 12 weeks. Clinical evaluation included size of patches (using 1 ×1 cm2 schablone), total number...
Source: Archives of Dermatological Research - November 9, 2019 Category: Dermatology Source Type: research

Bullous dermatoses secondary to anti-PD-L1 agents: a case report and review of the literature
Immune checkpoint inhibitors are used to treat numerous malignancies but may be associated with severe adverse events. Bullous dermatoses, chiefly bullous pemphigoid (BP), are potentially progressive adverse events that cause blistering skin lesions and may involve a significant body surface area. Herein, we report an 87-year-old man with urothelial cell carcinoma undergoing atezolizumab treatment who presented with an acute-onset blistering eruption. Biopsy revealed a subepidermal bulla, direct immunofluorescence revealed linear IgG and C3 deposits at the dermal-epidermal junction, and serum studies revealed elevated leve...
Source: Dermatology Online Journal - November 8, 2019 Category: Dermatology Source Type: research

Determination and occurrence of natural and synthetic glucocorticoids in surface waters.
In this study, we developed an original analytical method for simultaneously monitoring 25 natural GCs, and 43 synthetic GCs (4 hydrocortisone types, 6 acetonide types, 8 betamethasone types, 14 halogenated esters, and 11 labile prodrug esters) in water samples. Of the river samples investigated, 15 natural and 25 synthetic compounds were detected with the concentrations ranging from 0.13 ng/L (11-epitetrahydrocortisol) to 433 ng/L (cortisone) and from 0.05 (clobetasol) to 94 ng/L (prednisolone), respectively. Thirteen natural metabolites of cortisol (CRL) were first detected, and their concentrations were up to 36 t...
Source: Environment International - November 8, 2019 Category: Environmental Health Authors: Shen X, Chang H, Sun Y, Wan Y Tags: Environ Int Source Type: research

[Penile malakoplakia associated with lichen sclerosus].
CONCLUSION: We report a case of penile malakoplakia associated with chronic E. coli urinary tract infection, due originally to associated genital lichen sclerosus. PMID: 31627929 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - October 15, 2019 Category: Dermatology Authors: Amsellem J, Corgibet F, Ponnelle T, Dauendorffer JN Tags: Ann Dermatol Venereol Source Type: research

Bullous dermatoses secondary to anti-PD-L1 agents: a case report and review of the literature.
Abstract Immune checkpoint inhibitors are used to treat numerous malignancies but may be associated with severe adverse events. Bullous dermatoses, chiefly bullous pemphigoid (BP), are potentially progressive adverse events that cause blistering skin lesions and may involve a significant body surface area. Herein, we report an 87-year-old man with urothelial cell carcinoma undergoing atezolizumab treatment who presented with an acute-onset blistering eruption. Biopsy revealed a subepidermal bulla, direct immunofluorescence revealed linear IgG and C3 deposits at the dermal-epidermal junction, and serum studies reve...
Source: Dermatol Online J - October 15, 2019 Category: Dermatology Authors: Kosche C, Owen JL, Sadowsky LM, Choi JN Tags: Dermatol Online J Source Type: research

Osteoporotic vertebral fracture caused by topical corticosteroid abuse: A case report.
Authors: Piaserico S, Linder D, Messina F, Alaibac M Abstract In the present case report, a 32-year-old man with a 20-year long history of psoriasis, who presented with severe lower back pain and had no records of previous trauma, is reported. The patient reported the regular use of clobetasol cream, for 8 years, at an average dosage of 100 grams (g) per week. At the time of visit, the patient presented with severe psoriasis, which was associated with a cushingoid appearance. An X-ray of the spine was performed and the results revealed diffuse vertebral collapse that was caused by osteoporosis. The patient was diag...
Source: Experimental and Therapeutic Medicine - October 2, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

A review of topical corticosteroid sprays for the treatment of inflammatory dermatoses
Background: Topical corticosteroids are available in many vehicles. However, patients' preference for vehicles are variable and could be tailored to maximize patient adherence. Spray vehicles may offer, convenience, and strong efficacy. Methods: A literature review was conducted using keywords: clobetasol, desoximetasone, betamethasone, triamcinolone, corticosteroid, topical, spray, vehicles, treatment, and clinical trial. Results: For moderate-to-severe plaque psoriasis, 87% of subjects achieved an Overall Disease Severity (ODS) Score ≤2 at week two and 78% achieved an ODS ≤1 after four weeks with clobetasol propion...
Source: Dermatology Online Journal - September 9, 2019 Category: Dermatology Source Type: research

407 Novel transcriptomic network interactions in the human skin treated with topical glucocorticoid
Glucocorticoids (GCs) are the most frequently used anti-inflammatory drugs in dermatology. However, the molecular signature of GCs and their receptor (GR) in human skin is largely unknown. We obtained full thickness skin biopsies from healthy volunteers before and after topical treatment with clobetasol propionate (CBP, 0.05% cream) applied for 24 hrs to the relatively sun-protected volar aspect of the upper arm skin. Our validated bioinformatics analysis of CBP-induced human skin transcriptome (RNASeq) identified numerous novel GC-responsive genes, including over a thousand non-coding RNAs. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 1, 2019 Category: Dermatology Authors: I. Budunova, L.N. Lili, A. Klopot, G. Baida, B. Readhead, J.T. Dudley Tags: Innate Immunity and Inflammation Source Type: research

Improvements of both inflammation and skin barrier in a human Th17 skin inflammation model by topical treatment with fixed-dose combination calcipotriene/betamethasone dipropionate foam
This study aimed to elucidate and compare such effects in a human Th17 skin inflammation model. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Erosive pustular dermatosis as a cause of delayed burn wound healing: A case report
A 38-year-old man was referred to the dermatology department because of a delayed healing of burn injuries. The patient was recently discharged from the hospital for electrical and thermal burn injuries on the face and body for which he underwent skin grafts. However, the wounds would not completely heal, even with treatment of a herpesvirus superinfection, multiple antibiotics treatments based on various bacterial cultures that were sampled from the beginning and adequate wound care. He only had a partial response to a combination of clobetasol and fusidic acid months after his skin grafts. (Source: Journal of the America...
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

Palmoplantar lichen planus: A case report
Lichen planus is an inflammatory mucocutaneous disease that usually affects skin, hair, nails and mucous menbranes. The flexural areas of the wrists, arms, and legs are mostly affected, but palms and soles are usually spared. Herein, we report a case of palmoplantar lichen planus. The 46-year-old man presented with numerous pruritic papules and scattered vesicles over palms and soles for two months. Topical clobetasol proprionate 0.05% ointment was given but the patient ’s condition was refractory. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - August 21, 2019 Category: Dermatology Source Type: research

A Review of Topical Corticosteroid Foams
Authors: Payne J, Habet KA, Pona A, Feldman SR Abstract BACKGROUND: Topical corticosteroids are efficacious treatment options for multiple dermatoses. However, ointments and cream corticosteroid vehicles can be cumbersome to patients and may act as a barrier to adherence. Foam vehicles may be preferred by some patients. OBJECTIVE: To evaluate the efficacy and safety of topical corticosteroid foams. METHODS: A literature review was conducted using the keywords “clobetasol,” “betamethasone,” “propionate,” “valerate,” “topical,” “foam,” “v...
Source: Journal of Drugs in Dermatology - August 20, 2019 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

A review of topical corticosteroid sprays for the treatment of inflammatory dermatoses.
Abstract BACKGROUND: Topical corticosteroids are available in many vehicles. However, patients' preference for vehicles are variable and could be tailored to maximize patient adherence. Spray vehicles may offer, convenience, and strong efficacy. METHODS: A literature review was conducted using keywords: clobetasol, desoximetasone, betamethasone, triamcinolone, corticosteroid, topical, spray, vehicles, treatment, and clinical trial. RESULTS: For moderate-to-severe plaque psoriasis, 87% of subjects achieved an Overall Disease Severity (ODS) Score ≤2 at week two and 78% achieved an ODS ≤1 after four w...
Source: Dermatol Online J - August 15, 2019 Category: Dermatology Authors: Habet KA, Kolli SS, Pona A, Feldman SR Tags: Dermatol Online J Source Type: research

Clobetasol propionate enhances neural stem cell and oligodendrocyte differentiation.
In conclusion, the results of the current study suggest that Clo may have a potential therapeutic benefit in neurological disorders affecting oligodendrocytes and neurons. PMID: 31363370 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - August 2, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Transcriptomic network interactions in the human skin treated with topical glucocorticoid clobetasol propionate
Glucocorticoids (GCs) are the most frequently used anti-inflammatory drugs in dermatology. However, the molecular signature of GCs and their receptor (GR) in human skin is largely unknown. Our validated bioinformatics analysis of human skin transcriptome (RNASeq) induced by topical glucocorticoid clobetasol propionate (CBP) in healthy volunteers identified numerous unreported GC-responsive genes, including over a thousand non-coding RNAs. We observed sexual and racial dimorphism in the CBP response including a shift towards IFN α/IFNγ and IL6/JAK/STAT3 signaling in female skin; and a larger response to CBP in A...
Source: Journal of Investigative Dermatology - June 24, 2019 Category: Dermatology Authors: Loukia N. Lili, Anna Klopot, Benjamin Readhead, Gleb Baida, Joel T. Dudley, Irina Budunova Tags: Original Article Source Type: research

Transcriptomic Network Interactions in Human Skin Treated with Topical Glucocorticoid Clobetasol Propionate
Glucocorticoids are the most frequently used anti-inflammatory drugs in dermatology. However, the molecular signature of glucocorticoids and their receptor in human skin is largely unknown. Our validated bioinformatics analysis of human skin transcriptome induced by topical glucocorticoid clobetasol propionate (CBP) in healthy volunteers identified numerous unreported glucocorticoid-responsive genes, including over a thousand noncoding RNAs. We observed sexual and racial dimorphism in the CBP response including a shift toward IFN- α/IFN-γ and IL-6/Jak/Signal transducer and activator of transcription (STAT) 3 si...
Source: Journal of Investigative Dermatology - June 24, 2019 Category: Dermatology Authors: Loukia N. Lili, Anna Klopot, Benjamin Readhead, Gleb Baida, Joel T. Dudley, Irina Budunova Tags: Original Article Source Type: research

Hairy leukoplakia in a patient undergoing anti-retroviral therapy
We report a case of hairy leukoplakia that developed in a patient undergoing anti-retroviral therapy. A 53-year old white male presented with mild erythema in the anterior maxillary gingiva and was managed with clobetasol gel, after excluding the possibility of candidiasis. Patient's medical history was significant for HIV, bipolar disorder, high blood pressure, high cholesterol, chronic bronchitis, smoking, and alcohol. His medications included Androgel, Axiron, atorvastatin, bupropion, clonazepam, finasteride, hydrochlorothiazide, lamotrigine, lisinopril, pantoprazole, Prezcobix, Trazadone, Truvada (200 mg emticitabine, ...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - June 13, 2019 Category: ENT & OMF Source Type: research

Hairy leukoplakia in a patient undergoing anti-retroviral therapy
We report a case of hairy leukoplakia that developed in a patient undergoing anti-retroviral therapy. A 53-year old white male presented with mild erythema in the anterior maxillary gingiva and was managed with clobetasol gel, after excluding the possibility of candidiasis. Patient's medical history was significant for HIV, bipolar disorder, high blood pressure, high cholesterol, chronic bronchitis, smoking, and alcohol. His medications included Androgel, Axiron, atorvastatin, bupropion, clonazepam, finasteride, hydrochlorothiazide, lamotrigine, lisinopril, pantoprazole, Prezcobix, Trazadone, Truvada (200 mg emticitabine, ...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - June 13, 2019 Category: ENT & OMF Authors: Dr. Kelcie Barnts, Dr. Celeste Abraham, Dr. Yi-Shing Lisa Cheng Tags: #124 Source Type: research

Dermatitis Herpetiformis: Novel Perspectives
Dermatitis herpetiformis (DH) is an inflammatory disease of the skin, considered the specific cutaneous manifesta¬tion of celiac disease (CD). Both DH and CD occur in gluten-sensitive individuals, share the same Human Leukocyte Antigen (HLA) haplotypes (DQ2 and DQ8), and improve following the adminis¬tration of a gluten-free diet. Moreover, almost all DH patients show typical CD alterations at the small bowel biopsy, ranging from villous atrophy to augmented presence of intraepithelial lymphocytes, and the generation of circulating autoantibodies against tissue transglutaminase (tTG). DH presents with polymorphic...
Source: Frontiers in Immunology - June 11, 2019 Category: Allergy & Immunology Source Type: research

Adrenal insufficiency secondary to topic clobetasol.
Authors: Bertholle-Gil J, Gil-Palmer A, Nicolau-Ramis J PMID: 31160043 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - June 5, 2019 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Degradation of glucocorticoids in aqueous solution by dielectric barrier discharge: Kinetics, mechanisms, and degradation pathways
Publication date: 15 October 2019Source: Chemical Engineering Journal, Volume 374Author(s): Yanan Liu, Cihao Wang, Xue Shen, Ai Zhang, Shuwen Yan, Xiang Li, Andere Clement Miruka, Shimin Wu, Ying Guo, Stéphanie OgnierAbstractPerformance and mechanism of non-thermal plasma (NTP) technology in removing glucocorticoids (GCs) was investigated using a dielectric barrier discharge (DBD) reactor with fluocinolone acetonide (FA), triamcinolone acetonide (TA) and clobetasol propionate (CP) as representative compounds. Effects of discharge power, plasma-working gases, initial pH, coexistence of ions, and various water matrice...
Source: Chemical Engineering Journal - May 31, 2019 Category: Chemistry Source Type: research

Evaluation of topical human platelet lysate versus topical clobetasol in management of methotrexate-induced oral ulceration in rheumatoid arthritis patients: Randomized-controlled clinical trial.
CONCLUSION: Human platelet lysate has superior effect when compared to one of the most potent topical corticosteroids, Clobetasol Propionate, in reducing pain and clinical signs of Methotrexate-induced oral ulcers in patients with rheumatoid arthritis. PMID: 31151076 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - May 28, 2019 Category: Allergy & Immunology Authors: Ahmed EM, Ali S, Gaafar SM, Rashed LM, Fayed HL Tags: Int Immunopharmacol Source Type: research

Skin lightening products’ violations in Europe: An analysis of the rapid alert system for dangerous non-food products 2005–2018
ConclusionsHazardous skin lightening products that are not in line with European cosmetics legislation are available on the European market. Most of the products are imported. The main risk associated with these products is the content of hydroquinone, mercury, and clobetasol propionate. It is important to bear in mind that this study focuses on the Rapex system and other sources of information may exist. Based on our findings, a more comprehensive evaluation by international authorities is justified. (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - May 10, 2019 Category: Toxicology Source Type: research

Genital lichen sclerosus et atrophicus in females: An update
Yogesh Marfatia, Ashma Surani, Reema BaxiIndian Journal of Sexually Transmitted Diseases and AIDS 2019 40(1):6-12Lichen sclerosus et atrophicus is an acquired chronic inflammatory dermatosis commonly affecting the vulvar and perianal regions. It is associated with an increased risk of vulvar cancer even though it is not a premalignant condition itself. The true precursor of cancer associated with lichen sclerosus (LS) is vulvar intraepithelial neoplasia (VIN), differentiated type. The diagnosis is usually clinical, but in some cases, a biopsy can be performed, especially to exclude VIN or cancer. All females with anogenita...
Source: Indian Journal of Sexually Transmitted Diseases - May 10, 2019 Category: Infectious Diseases Authors: Yogesh Marfatia Ashma Surani Reema Baxi Source Type: research

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 3, 2019 Category: Allergy & Immunology Source Type: research

Skin lightning products’ violations in Europe: An analysis of the rapid alert system for dangerous non-food products 2005–2018
ConclusionsHazardous skin lightning products that are not in line with European cosmetics legislation are available on the European market. Most of the products are imported. The main risk associated with these products is the content of hydroquinone, mercury, and clobetasol propionate. It is important to bear in mind that this study focuses on the RAPEX system and other sources of information may exist. Based on our findings, a more comprehensive evaluation by international authorities is justified. (Source: Regulatory Toxicology and Pharmacology)
Source: Regulatory Toxicology and Pharmacology - April 26, 2019 Category: Toxicology Source Type: research

Interventions for hand eczema.
CONCLUSIONS: Most findings were from single studies with low precision, so they should be interpreted with caution. Topical corticosteroids and UV phototherapy were two of the major standard treatments, but evidence is insufficient to support one specific treatment over another. The effect of topical calcineurin inhibitors is not certain. Alitretinoin is more effective than placebo in controlling symptoms, but advantages over other treatments need evaluating.Well-designed and well-reported, long-term (more than three months), head-to-head studies comparing different treatments are needed. Consensus is required regarding th...
Source: Cochrane Database of Systematic Reviews - April 26, 2019 Category: General Medicine Authors: Christoffers WA, Coenraads PJ, Svensson Å, Diepgen TL, Dickinson-Blok JL, Xia J, Williams HC Tags: Cochrane Database Syst Rev Source Type: research

Skin lightning products' violations in Europe: An analysis of the rapid alert system for dangerous non-food products 2005-2018.
CONCLUSIONS: Hazardous skin lightning products that are not in line with European cosmetics legislation are available on the European market. Most of the products are imported. The main risk associated with these products is the content of hydroquinone, mercury, and clobetasol propionate. It is important to bear in mind that this study focuses on the RAPEX system and other sources of information may exist. Based on our findings, a more comprehensive evaluation by international authorities is justified. PMID: 31029853 [PubMed - as supplied by publisher] (Source: Regulatory Toxicology and Pharmacology : RTP)
Source: Regulatory Toxicology and Pharmacology : RTP - April 25, 2019 Category: Toxicology Authors: Michalek IM, Liu B, Benn EKT, Dos Santos FLC Tags: Regul Toxicol Pharmacol Source Type: research

Glucocorticoid mixtures of fluticasone propionate, triamcinolone acetonide and clobetasol propionate induce additive effects in zebrafish embryos
Publication date: Available online 4 April 2019Source: Journal of Hazardous MaterialsAuthor(s): Raffael Alois Willi, Noelia Salgueiro-González, Giulia Carcaiso, Karl FentAbstractMany synthetic glucocorticoids from medical applications occur in the aquatic environment. Whether they pose a risk for fish health is poorly known. Here we investigate effects of glucocorticoids fluticasone propionate (FLU) and triamcinolone acetonide (TRI) as single steroids and as ternary mixtures with clobetasol propionate (CLO) in zebrafish embryos. Exposure to FLU and TRI in concentrations between 0.099 and 120.08 µg/L led...
Source: Journal of Hazardous Materials - April 8, 2019 Category: Environmental Health Source Type: research

Reducing Unpleasant Side Effects of Topical 5-Flourouracil Treatment for Actinic Keratosis: A Randomized Controlled Trial.
CONCLUSIONS: Given the low cost, wide availability, and ability to significantly reduce erythema, petrolatum should be used post-5-FU treatment for diffuse AK. TRIAL REGISTRATION: The Clinicaltrials.gov registration number is NCT03279328. PMID: 30821548 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 4, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Clobetasol/desonide/triamcinolone
(Source: Reactions Weekly)
Source: Reactions Weekly - February 1, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of the effectiveness of treatment of vulvar lichen sclerosus et atrophicus. Analysis of own material and review of the literature.
CONCLUSIONS: Vulvar lichen sclerosus et atrophicus is a chronic condition requiring long-term treatment. Topical use of steroids as first-line drugs bring a good local control of lesions in most women, yet further search of other possible causes of LSA is necessary. PMID: 30664348 [PubMed - as supplied by publisher] (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - January 23, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Vasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris.
Vasoconstrictor potency of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam versus other topical corticosteroids used to treat psoriasis vulgaris. J Dermatolog Treat. 2018 Dec 24;:1-22 Authors: Queille-Roussel C, Nielsen J, Lacour JP Abstract BACKGROUND: It is important to determine the vasoconstrictor potencies of topical corticosteroids used to treat psoriasis to ensure appropriate clinical use. OBJECTIVE: To compare the vasoconstrictive potencies of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5...
Source: Journal of Dermatological Treatment - December 26, 2018 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Scalp Sarcoidosis Presenting as Cicatricial Alopecia.
Authors: Prohaska J, Demaree E, Powers J, Cook C Abstract Sarcoidosis is a granulomatous condition that has a highly variable presentation. One rare presentation of sarcoidosis is cutaneous scalp sarcoidosis. Usually scalp sarcoid presents as a scarring alopecia, but it can be nonscarring. The presence of sarcoidal lesions on the scalp is associated with systemic disease, as are other cutaneous manifestations of sarcoidosis. The authors present the case of a 64-year-old woman with a history of sarcoidosis who presented with alopecia and hypopigmented patches on her scalp. She also had papular sarcoid lesions on her...
Source: Journal of the American Osteopathic Association - November 28, 2018 Category: Complementary Medicine Tags: J Am Osteopath Assoc Source Type: research

Bone infarction of the hip after hand allotransplantation: A case report
AbstractVascularized composite allotransplantation represents as an emerging field in reconstructive surgery. However, some complications can be associated with the procedure. The authors describe a case of bone infarctions of the bilateral hip joints following the first hand allotransplantation in Taiwan. A 45 ‐year‐old man who experienced a traumatic amputation of the distal third of his forearm received a hand transplantation from a brain‐dead donor. Immunosuppression included antithymocyte globulins, and bolus methylprednisolone (Solu‐Medrol) was used for the induction. The maintenance therapy protocol included...
Source: Microsurgery - November 27, 2018 Category: Surgery Authors: Yur ‐Ren Kuo, Chien‐Chang Chen, Jun‐Wen Wang, Jui‐Kun Chang, Yu‐Chi Huang, Cheng‐Chung Pan, Yi‐Chun Lin, Re‐Wen Wu, Chen‐Hsiang Lee Tags: CASE REPORT Source Type: research

Novel Therapy for Aggressive Cutaneous T-Cell Lymphoma Leading to Complete Clinical Remission before Allogenic Stem Cell Transplantation
Cutaneous T-cell lymphomas (CTCL) represent up to 80% of extranodal non-Hodgkin Lymphomas, the most common being Mycosis Fungoides (MF) with or without its leukemic stage Sezary Syndrome and Primary cutaneous CD30+ T-cell lymphoproliferative disorders. Prognosis for advanced stages is poor, with 5-year survival 40-70% for patients with advanced skin stages, and 15-40% for those with extracutaneous involvement and CD30+ transformed CTCL. The disease is considered incurable, and most patients will undergo at least two different lines of therapy, and up to 36% undergo at least four different lines due to a short duration of r...
Source: Blood - November 21, 2018 Category: Hematology Authors: Gallastegui Crestani, N., Ibrahim, M. E., Mohamed, A. M., Romanelli, P., Beitinjaneh, A., Schatz, J. H. Tags: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma-Clinical Studies Source Type: research