Clobetasol propionate 0.05% under occlusion for alopecia areata: Clinical effect and influence on intraocular pressure.
Abstract Topical corticosteroids are known to be effective in the treatment of alopecia areata, but the potential effects on intraocular pressure are a concern. The purpose of this retrospective study is to evaluate the effect of clobetasol propionate 0.05% under occlusion on patients with active phase alopecia areata and to examine the effects on intraocular pressure. We also wished to see if reducing the frequency of application of clobetasol increased the safety with respect to intraocular pressure. Elevation of intraocular pressure due to topical corticosteroids is unlikely to occur at the dose of 9.8 g o...
Source: The Australasian Journal of Dermatology - January 3, 2021 Category: Dermatology Authors: Nomiyama T, Katoh N Tags: Australas J Dermatol Source Type: research

PD1 inhibitor induced inverse lichenoid eruption: a case series
We describe two patients who presented with nearly identical deeply erythematous, malodorous, eroded anogenital plaques with focal crusting. Diagnosis of PILE was established given the biopsy findings and temporal association with PD1 inhibitor therapy. Treatment with clobetasol ointment was successful without necessitating discontinuation of immunotherapy. The findings were consistent with the only other previously published case of inverse lichenoid eruption in the groin secondary to PD1 inhibitors. (Source: Dermatology Online Journal)
Source: Dermatology Online Journal - December 29, 2020 Category: Dermatology Source Type: research

IJERPH, Vol. 18, Pages 56: Analysis of the Efficacy of Two Treatment Protocols for Patients with Symptomatic Oral Lichen Planus: A Randomized Clinical Trial
In conclusion, the results evidenced that, compared to clobetasol, the anti-inflammatory was less effective in determining the reduction of signs and symptom in OLP patients. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - December 23, 2020 Category: Environmental Health Authors: Simona Santonocito Alessandro Polizzi Rocco De Pasquale Vincenzo Ronsivalle Antonino Lo Giudice Gaetano Isola Tags: Article Source Type: research

PD1 inhibitor induced inverse lichenoid eruption: a case series.
We describe two patients who presented with nearly identical deeply erythematous, malodorous, eroded anogenital plaques with focal crusting. Diagnosis of PILE was established given the biopsy findings and temporal association with PD1 inhibitor therapy. Treatment with clobetasol ointment was successful without necessitating discontinuation of immunotherapy. The findings were consistent with the only other previously published case of inverse lichenoid eruption in the groin secondary to PD1 inhibitors. PMID: 33423421 [PubMed - in process] (Source: Dermatol Online J)
Source: Dermatol Online J - December 15, 2020 Category: Dermatology Authors: Sethi M, Garg V, Lee JB, Yang S Tags: Dermatol Online J Source Type: research

17043 Frontal fibrosing alopecia severity score: A 3-year prospective study
The Frontal Fibrosing Alopecia Severity Score (FFASS) was described to classify frontal fibrosing alopecia (FFA) patients. Its prospective use can help us to understand better the relationship between inflammation and hairline recession. We conducted a three-year prospective study. All patients started the same treatment in the first visit (oral dutasteride 0.5 mg 3 times a week, topical clobetasol twice weekly and triamcinolone injections 4-8 mg/mL). Patients were assessed with the FFASS every 6 months. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: David Saceda-Corralo, Cristina Pindado-Ortega, Diego Fernandez-Nieto, Juan Jimenez-Cauhe, Daniel Ortega-Quijano, Rita Rodrigues-Barata, Óscar M. Moreno-Arrones, Sergio Vaño-Galvan Source Type: research

17156 Psoriasis improvement and satisfaction in patients using a clobetasol spray and oral apremilast combination regimen: A pilot study
This study investigated whether an initial 6-week tapering regimen of clobetasol spray could improve PASI 75 and sPGA response at 16 weeks in patients with moderate to severe psoriasis who initiate apremilast. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 28, 2020 Category: Dermatology Authors: Chapman Wei, Ronald B. Prussick, Adam Friedman Source Type: research

A case report of hydroxychloroquine-induced auditory and visual hallucination.
DISCUSSION: Previous studies and the lack of another explanation for the patient's hallucinations imply a strong correlation between hydroxychloroquine and hallucinations. The mechanism of these side effects has not been fully elucidated. However, this side effect has only been reported in cases of connective tissue diseases. As currently hydroxychloroquine is widely used in the treatment of COVID-19 and other diseases, its potential risk of psychiatric complications should be considered in clinical practice. PMID: 33191905 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - November 18, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Topical Therapies for Psoriasis in Phase 3 Trials
AbstractPurpose of ReviewThis review will discuss new topical therapeutics for psoriasis that have undergone or published phase III trials in the last 5  years, as well as promising therapeutics in development.Recent FindingsNew corticosteroid-only additions to the marketplace include formulations that improve absorption and ease-of-use, including betamethasone dipropionate (BD) 0.05% spray, halobetasol propionate (HP) 0.05% foam and 0.01% lotion, and clobetasol propionate 0.025% cream. Combination therapies include BD 0.064% plus calcipotriene 0.005% (Cal/BD) foam, Cal/BD cream, and HP 0.01% plus tazarotene 0.045% lo...
Source: Current Dermatology Reports - November 5, 2020 Category: Dermatology Source Type: research

Topical delivery of clobetasol propionate loaded nanosponge hydrogel for effective treatment of psoriasis: Formulation, physicochemical characterization, antipsoriatic potential and biochemical estimation
Publication date: February 2021Source: Materials Science and Engineering: C, Volume 119Author(s): Sunil Kumar, Minakshi Prasad, Rekha Rao (Source: Materials Science and Engineering: C)
Source: Materials Science and Engineering: C - October 24, 2020 Category: Materials Science Source Type: research

Clobetasol Attenuates White Matter Injury by Promoting Oligodendrocyte Precursor Cell Differentiation
Conclusions: Our results indicate that clobetasol attenuates WMI by promoting OPC differentiation, and it may be an effective therapeutic agent for the treatment of preterm WMI.Pediatr Neurosurg (Source: Pediatric Neurosurgery)
Source: Pediatric Neurosurgery - October 9, 2020 Category: Neurosurgery Source Type: research

Iatrogenic hypercortisolism in a Persian kitten after topical application of a skin lotion containing clobetasol.
This report describes the clinicopathological findings and successful management of iatrogenic hypercortisolism in a Persian kitten. The disorder was presumed to be a consequence of prolonged topical application of a lotion containing clobetasol. PMID: 33029837 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - October 7, 2020 Category: Veterinary Research Authors: Chirayath D, Shaheena S Tags: Vet Dermatol Source Type: research

Oral ulcers induced by low methotrexate doses: a case report
A 66-year-old male patient with psoriatic arthritis who received methotrexate (MTX) 25 mg/wk was hospitalized for ureteral reimplantation, presenting nausea, vomiting, loss of appetite, and oral ulceration. Physical examination revealed multiple ulcerations in the lower labial mucosa, with intense painful symptoms and spontaneous bleeding. The diagnostic hypothesis was of ulcerations associated with the drug. Treatment was performed with 0.05% clobetasol propionate with no satisfactory response. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 31, 2020 Category: ENT & OMF Authors: JOANA LET ÍCIA SCHORR, GISELE CORRÊA DE OLIVEIRA ZIGMUNDO, JESSICA RODRIGUEZ STREY, LARISSA GABRIELY OLIVEIRA CAVALCANTI, MANOELA DOMINGUES MARTINS, VINICIUS COELHO CARRARD, MARCO ANTÔNIO TREVIZANI MARTINS Tags: 20190684 Source Type: research

Necrotizing leukocytoclastic small vessel  vasculitis associated with letrozole: A case report
.
DISCUSSION: Pathogenesis of vasculitis caused by aromatase inhibitors is not fully elucidated, but estrogen depletion and idiosyncratic drug reaction has been proposed. Cutaneous leukocytoclastic small vessel vasculitis (CLSVV) resulting from aromatase inhibitors is relatively rare so it is recommended to consider drug-induced CLSVV in other patients treated with aromatase inhibitors. PMID: 32831164 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - August 25, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

Safety and Efficacy of Clobetasol Propionate 0.05% Emollient Foam for the Treatment of Central Centrifugal Cicatricial Alopecia.
Conclusion: Subjects with CCCA that applied topical clobetasol propionate 0.05% emollient foam to their scalp daily demonstrated continuous clinical improvement throughout the 14-week study. ClinicalTrials.gov Identifier: NCT01111981 J Drugs Dermatol. 2020;19(7): doi:10.36849/JDD.2020.5201. PMID: 32726554 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - July 31, 2020 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Topical Corticosteroids a Viable Solution for Oral Graft Versus Host Disease? A Systematic Insight on Randomized Clinical Trials.
Conclusions: Based on the clinical trials, all three agents seem to be effective in treating oral GVHD and had a satisfactory safety profile. There is still a need for assessing high quality RCTs to assess the efficacy of these therapies on a larger cohort. PMID: 32674447 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 13, 2020 Category: Universities & Medical Training Authors: Sava A, Piciu A, Pasca S, Mester A, Tomuleasa C Tags: Medicina (Kaunas) Source Type: research

Effects of environmental steroid mixtures are regulated by individual steroid receptor signaling.
Abstract Fish are exposed to steroids of different classes in contaminated waters, but their effects are not sufficiently understood. Here we employed an anti-sense technique using morpholino oligonucleotides to knockdown the glucocorticoid receptors (GRs, GRα and GRβ) and androgen receptor (AR) to investigate their role in physiological and transcriptional responses. To this end, zebrafish embryos were exposed to clobetasol propionate (CLO), androstenedione (A4) and mixtures containing different classes of steroids. CLO caused a decrease of spontaneous muscle contraction and increase of heart rate, as ...
Source: Aquatic Toxicology - July 2, 2020 Category: Toxicology Authors: Schmid S, Willi RA, Fent K Tags: Aquat Toxicol Source Type: research

Ophiasis alopecia areata treated with microneedling.
We present a case of a 58-year-old white man with AA, ophiasis pattern, who was treated with clobetasol 0.05% solution and four treatments of microneedling with triamcinolone over 6 months. He underwent gradual improvement, most notably on his left occipital scalp where his hair loss was most prominent, with near complete hair regrowth on his left occipital scalp. Microneedling with triamcinolone can be considered as a promising treatment in cases of ophiasis AA. PMID: 32675968 [PubMed] (Source: Baylor University Medical Center Proceedings)
Source: Baylor University Medical Center Proceedings - June 30, 2020 Category: Universities & Medical Training Authors: Asad U, Wallis D, Tarbox M Tags: Proc (Bayl Univ Med Cent) Source Type: research

097 Reactivation of pyoderma gangrenosum associated with anti-programmed cell death 1 therapy
We describe two patients with clinical and histological findings consistent with pyoderma gangrenosum (PG) that was reactivated after receiving PD-1 inhibitor therapy. We successfully treated our first patient with wound care with clobetasol ointment and triamcinolone acetonide injections. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - June 17, 2020 Category: Dermatology Authors: W. Haidari, K. Coerdt, G. Gibney, H.B. Pasieka Tags: Adaptive and Auto-Immunity Source Type: research

Oral lichen planus with cutaneous manifestations: case report with emphasis on dental diagnostic criteria
The objective of this study is to report a case of oral lichen planus (OLP) with cutaneous manifestations and to discuss the clinical, histopathological aspects and the established treatment. A 61-years-old female white patient was referred for evaluation of white lesions in the oral mucosa. In the intraoral examination, multiple white lesions with striated appearance were observed in the jugal mucosa, tongue and border. The extraoral examination revealed scaly lesions on the arm, white spots on the legs, and nail dystrophy on feet. Based on biopsy of the oral lesions and the histopathological analysis, the diagnosis of OL...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - May 29, 2020 Category: Pathology Source Type: research

The efficacy and safety of oral low dose naltrexone versus placebo in the patients with lichen planopilaris; a randomized controlled clinical trial.
Conclusion: Low dose naltrexone (3mg) failed to improve the severity of the LPP more than what is achievable with topical clobetasol. PMID: 32449418 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - May 26, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Drugs for Atopic Dermatitis
Date: June 15, 2020 Issue #:  1600Summary:  Atopic dermatitis (AD; also known as eczema) is frequently associated with other atopic disorders such as allergic rhinitis, asthma, and food allergy. It commonly presents in infancy and early childhood and has a relapsing course, often improving by adolescence, but sometimes persisting into (or first appearing in) adulthood or even old age. (Source: The Medical Letter)
Source: The Medical Letter - May 12, 2020 Category: Drugs & Pharmacology Authors: admin Tags: abrocitinib Alclometasone Amcinonide ApexiCon apremilast Atopic dermatitis Azasan Azathioprine baricitinib Betamethasone Clobetasol Clobex Clocortolone Cloderm Cordran corticosteroids crisaborole Cutivate Cyclosporine Source Type: research

Efficacy and Safety of Topical Calcipotriol 0.005% Versus Topical Clobetasol 0.05% in the Management of Alopecia Areata: An Intrasubject Pilot Study
ConclusionsTreatment with the calcipotriol would appear to be reasonably effective in patients with mild to moderate patchy AA and was associated with only limited and reversible side effects. (Source: Dermatology and Therapy)
Source: Dermatology and Therapy - April 26, 2020 Category: Dermatology Source Type: research

Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies
Publication date: Available online 23 April 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Yu-ting Lu, Rong Guan, Jia-run Zheng, Tai-jun Hang, Min Song (Source: Journal of Pharmaceutical and Biomedical Analysis)
Source: Journal of Pharmaceutical and Biomedical Analysis - April 24, 2020 Category: Drugs & Pharmacology Source Type: research

Nivolumab-induced bullous pemphigoid managed without drug withdrawal
We report a case of bullous pemphigoid secondary to nivolumab therapy for metastatic renal carcinoma with a previously unreported complete response to clobetasol ointment alone. The autoimmune blistering disease was successfully treated without oral corticosteroids, and the anti-PD-1 agent could be maintained without recurrence of the skin lesions. Topical therapy remains a good option in selected, mild-to-moderate cases of induced bullous pemphigoid. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - April 13, 2020 Category: Dermatology Authors: M & #243;nica Munera-Campos Adri & #224; Plana-Pla Noelia Rivera Aram Boada Carlos Ferr & #225;ndiz Source Type: research

Recurrence of herpes zoster infection in the setting of topical immunosuppression for erosive pustular dermatosis of the scalp
We present a unique patient with erosive pustular dermatosis of the scalp (EPDS) with several unique features: (1) a rare case of EPDS occurring after herpes zoster (HZ) infection and (2) the first reported case of recurrence of HZ induced by topical immunosuppressive therapy (clobetasol 0.05% cream and tacrolimus 0.01% cream) in a patient with underlying EPDS. Based on our patient, we recommend to exercise caution with the prolonged use of potent topical steroids in areas previously affected by herpes zoster. (Source: International Journal of Trichology)
Source: International Journal of Trichology - April 8, 2020 Category: Dermatology Authors: Farah Moustafa Michela Starace Giulia Ravaioli Bianca Maria Piraccin Source Type: research

Oral isotretinoin combined with topical clobetasol 0.05% and tacrolimus 0.1% for the treatment of frontal fibrosing alopecia: A randomized controlled trial.
Authors: Mahmoudi H, Rostami A, Tavakolpour S, Nili A, Teimourpour A, Salehi Farid A, Abedini R, Amini M, Daneshpazhooh M Abstract Background: Frontal fibrosing alopecia (FFA) is a scarring alopecia with no promising treatment.Objective: To evaluate the additive efficacy of oral isotretinoin to topical treatments.Methods: Between November 2017 and August 2018, FFA patients were randomly assigned to receive either isotretinoin (20mg/d) plus topical treatments (clobetasol 0.05% and tacrolimus 0.1%) or monotherapy with topical treatments. Treatments' efficacy was evaluated through Frontal Fibrosing Alopecia Severity I...
Source: Journal of Dermatological Treatment - April 3, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

09: A randomized controlled trial of clobetasol propionate versus fractionated CO2 laser for the treatment of lichen sclerosus (CURLS)
To compare six month safety and efficacy outcomes of fractionated CO2 laser (laser) to topical clobetasol propionate (steroid) for treatment of symptomatic vulvar lichen sclerosus. (Source: American Journal of Obstetrics and Gynecology)
Source: American Journal of Obstetrics and Gynecology - February 28, 2020 Category: OBGYN Authors: L. Burkett, M. Siddique, A. Zeymo, R.E. Gutman, A.J. Park, C. Iglesia Tags: Oral Presentation Source Type: research

Interventions for treating oral lichen planus: corticosteroid therapies.
CONCLUSIONS: Corticosteroids have been first line for the treatment of OLP. This review found that these drugs, delivered topically as adhesive gels or similar preparations, may be more effective than placebo for reducing the pain of symptomatic OLP; however, with the small number of studies and participants, our confidence in the reliability of this finding is low. The results for clinical response were inconclusive, and we are uncertain about adverse effects. Very low-certainty evidence suggests that calcineurin inhibitors, specifically tacrolimus, may be more effective at resolving pain than corticosteroids, although th...
Source: Cochrane Database of Systematic Reviews - February 27, 2020 Category: General Medicine Authors: Lodi G, Manfredi M, Mercadante V, Murphy R, Carrozzo M Tags: Cochrane Database Syst Rev Source Type: research

Psoriasis improvement and satisfaction in patients utilizing a clobetasol spray and oral apremilast combination regimen- a pilot study
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - February 19, 2020 Category: Dermatology Authors: Chapman Wei, Adam J. Friedman, Ronald B. Prussick Source Type: research

Psoriasis improvement and satisfaction in patients using a clobetasol spray and oral apremilast combination regimen: A pilot study
To the Editor: Apremilast is  an oral phosphodiesterase-4 inhibitor with a 33% efficacy of achieving Psoriasis Area and Severity Improvement (PASI) 75 at 16 weeks for patients with moderate to severe plaque psoriasis.1 Common adverse effects include gastrointestinal symptoms, headache, and nasopharyngitis.1 Clobetasol propi onate spray 0.05%, a clobetasol formulation with similar efficacy and potency to other topical clobetasol preparations, is effective at achieving rapid PASI 75 reduction at 4 weeks but cannot be used long-term because of potential skin and adrenal adverse effects. (Source: ...
Source: Journal of the American Academy of Dermatology - February 19, 2020 Category: Dermatology Authors: Chapman Wei, Adam J. Friedman, Ronald B. Prussick Tags: Letter Source Type: research

Comparison of topical clobetasol propionate 0.05% and topical tacrolimus 0.1% in the treatment of cutaneous lichen planus.
Authors: Özkur E, Aksu EK, Gürel MS, Savaş S Abstract Introduction: The effectiveness of topical tacrolimus in the treatment of oral and genital lichen planus has been verified in many randomized studies; however, there are only few case reports in treatment of cutaneous lichen planus (CLP). Aim: We sought to compare the safety and efficacy of topical clobetasol propionate and tacrolimus ointment in the treatment of CLP. Material and methods: Retrospective analysis of patient files was performed. We enrolled patients who were diagnosed with CLP and treated with topical tacrolimus 0.1% or topical ...
Source: Advances in Dermatology and Allergology - February 1, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Clobetasol/clobetasone overdose
(Source: Reactions Weekly)
Source: Reactions Weekly - January 31, 2020 Category: Drugs & Pharmacology Source Type: research

Unbearable wearables
As wearable devices play an increasing role in the management of health and disease, adverse skin reactions to wearables have become more common. However, the management of allergic contact dermatitis is challenging and new treatment options more compatible with wearable devices are needed. In a 40-year-old woman with contact dermatitis to a continuous glucose monitoring device, topical clobetasol propionate 0.05% spray proved to be an effective treatment that was compatible with the application of adhesive wearables. This case demonstrates that spray formulations of topical steroids are a good option for the treatment of ...
Source: Dermatology Online Journal - January 29, 2020 Category: Dermatology Source Type: research

[ASAP] Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5
Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.9b02067 (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - January 22, 2020 Category: Chemistry Authors: William C. Wright †‡, Jude Chenge†, Jingheng Wang†, Hazel M. Girvan§, Lei Yang†, Sergio C. Chai†, Andrew D. Huber†, Jing Wu†, Peter O. Oladimeji†, Andrew W. Munro§, and Taosheng Chen*† Source Type: research

Iontophoretic delivery of methotrexate in the treatment of palmar psoriasis: A randomised controlled study.
CONCLUSION: Iontophoretic delivery of methotrexate is a promising therapeutic modality, the efficacy of which is comparable to that of clobetasol propionate ointment in the treatment of palmar psoriasis. PMID: 31944270 [PubMed - as supplied by publisher] (Source: The Australasian Journal of Dermatology)
Source: The Australasian Journal of Dermatology - January 15, 2020 Category: Dermatology Authors: Andanooru Chandrappa NK, Channakeshavaiah Ravikumar B, Rangegowda SM Tags: Australas J Dermatol Source Type: research

17 β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish.
17β-Estradiol and the glucocorticoid clobetasol propionate affect the blood coagulation cascade in zebrafish. Environ Pollut. 2019 Dec 18;259:113808 Authors: Schmid S, Fent K Abstract Fish are exposed to estrogens, progestins and glucocorticoids in the aquatic environment but effects on the blood coagulation cascade are unknown. Here we analyzed effects of 17β-estradiol (E2) alone and in combination with mixtures of new generation progestins and the glucocorticoid clobetasol propionate (CLO) in zebrafish embryos to assess their effects on the blood coagulation system. We assessed transcripts...
Source: Environmental Pollution - December 17, 2019 Category: Environmental Health Authors: Schmid S, Fent K Tags: Environ Pollut Source Type: research

A rare case of non-Langerhans cell histiocytosis/ Erdheim-Chester disease presenting as desquamative gingivitis and oral mucosal erythema
ConclusionsThis is the first report of potential oral mucosal involvement of ECD, with the noted desquamative gingivitis and erythema as its oral presentation. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Localized carbon dioxide laser treatment of a recalcitrant oral ulceration in pemphigus vulgaris
ConclusionsAdjunctive procedures that can facilitate a decrease in the cumulative dosages of corticosteroids and immunosuppressants have great value in the management of PV. CO2 laser vaporization is a safe procedure with minimal morbidity and no long-term side effects and should be considered as an adjunctive treatment option for management of recalcitrant lesions in patients with oral PV. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 15, 2019 Category: ENT & OMF Source Type: research

Treatment of oral chronic graft-vs-host disease with clobetasol: case report
Graft-vs-host disease (GVHD) is the main complication of allogeneic hematopoietic stem cells transplantation. A 29-year-old Brazilian man was diagnosed as having severe aplastic anemia and submitted to allogeneic HSCT in October 2013. He developed systemic chronic GVHD, including the oral cavity (lichenoid lesions in right and left buccal mucosa and labial hyperchromia and was treated with mycophenolate mofetil, tacrolimus, cyclosporine, and dexamethasone solution [mouthwash]). Upon stabilization of chronic GVHD in the oral cavity, the patient displayed gingival atrophy and erythema (12-21/33-42) on July 27, 2017. (Source:...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: BARBARA BARRETO PACHECO VALENTIM, GABRIELA DE ASSIS RAMOS, CAMILA BRAND ÃO LOBO, TAÍSA DOMINGUES BERNARDES SILVA, HELITON SPINDOLA ANTUNES Source Type: research

Diagnosis of lupus erythematosus by oral lesions: case report
A 49-year-old white female patient presented bilateral white plaques on the buccal mucosa and lateral border of tongue with erythematous background, which was asymptomatic. On anamnesis, the patient reported bald patches in the midscalp region. The oral lesions were treated with 0.05% aqueous clobetasol solution for 15 days without significant improvement. The clobetasol concentration was increased to 0.1% for a further 15 days without significant improvement of the lesions. All treatments were suspended for 15 days, and a biopsy was proposed. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: YURI KALININ, SUELLEN VIEIRA DO NASCIMENTO, CL ÁUDIA PEREZ TRINDADE FRAGA, NARA MARIA VASCONCELOS IELO, LUCYENE MIGUITA LUIZ, MARCELO MARCUCCI Source Type: research

Unbearable wearables.
Abstract As wearable devices play an increasing role in the management of health and disease, adverse skin reactions to wearables have become more common. However, the management of allergic contact dermatitis is challenging and new treatment options more compatible with wearable devices are needed. In a 40-year-old woman with contact dermatitis to a continuous glucose monitoring device, topical clobetasol propionate 0.05% spray proved to be an effective treatment that was compatible with the application of adhesive wearables. This case demonstrates that spray formulations of topical steroids are a good option for...
Source: Dermatol Online J - December 14, 2019 Category: Dermatology Authors: Wei JJ, Hayward EM, Leung TH, Rosenbach M Tags: Dermatol Online J Source Type: research

Effects of the glucocorticoid clobetasol propionate and its mixture with cortisol and different class steroids in adult female zebrafish
Publication date: Available online 23 November 2019Source: Aquatic ToxicologyAuthor(s): Susanne Faltermann, Timm Hettich, Noemi Küng, Karl FentAbstractEcotoxicological effects of glucocorticoids and steroid mixtures in the environment are not sufficiently known. Here we investigate effects of 11-14 days exposure of female zebrafish to the glucocorticoid clobetasol propionate (Clo), cortisol (Cs), their mixture and mixtures with five different class steroids (Clo + triamcinolone + estradiol + androstendione + progesterone) in liver, brain and gonads. Cs showed lit...
Source: Aquatic Toxicology - November 25, 2019 Category: Toxicology Source Type: research

The comparison of therapeutic effect of Clobetasol propionate lotion and squill extract in alopecia areata: a randomized, double-blind clinical trial
AbstractAlopecia areata is a chronic inflammatory disease that characterized by round or oval patches of non-scarring hair loss. From the past,Urginea maritima (white squill) was used for the treatment of hair loss in Iranian traditional medicine. We aimed the comparison of Clobetasol lotion and squill extract efficacy in treatment of alopecia areata in a randomized, double-blind clinical trial. The 42 patients were randomized into two groups. Both groups received topical squill and clobetasol lotion twice daily lotion for 12 weeks. Clinical evaluation included size of patches (using 1 ×1 cm2 schablone), total number...
Source: Archives of Dermatological Research - November 8, 2019 Category: Dermatology Source Type: research

Bullous dermatoses secondary to anti-PD-L1 agents: a case report and review of the literature
Immune checkpoint inhibitors are used to treat numerous malignancies but may be associated with severe adverse events. Bullous dermatoses, chiefly bullous pemphigoid (BP), are potentially progressive adverse events that cause blistering skin lesions and may involve a significant body surface area. Herein, we report an 87-year-old man with urothelial cell carcinoma undergoing atezolizumab treatment who presented with an acute-onset blistering eruption. Biopsy revealed a subepidermal bulla, direct immunofluorescence revealed linear IgG and C3 deposits at the dermal-epidermal junction, and serum studies revealed elevated leve...
Source: Dermatology Online Journal - November 8, 2019 Category: Dermatology Source Type: research

Determination and occurrence of natural and synthetic glucocorticoids in surface waters.
In this study, we developed an original analytical method for simultaneously monitoring 25 natural GCs, and 43 synthetic GCs (4 hydrocortisone types, 6 acetonide types, 8 betamethasone types, 14 halogenated esters, and 11 labile prodrug esters) in water samples. Of the river samples investigated, 15 natural and 25 synthetic compounds were detected with the concentrations ranging from 0.13 ng/L (11-epitetrahydrocortisol) to 433 ng/L (cortisone) and from 0.05 (clobetasol) to 94 ng/L (prednisolone), respectively. Thirteen natural metabolites of cortisol (CRL) were first detected, and their concentrations were up to 36 t...
Source: Environment International - November 7, 2019 Category: Environmental Health Authors: Shen X, Chang H, Sun Y, Wan Y Tags: Environ Int Source Type: research

Bullous dermatoses secondary to anti-PD-L1 agents: a case report and review of the literature.
Abstract Immune checkpoint inhibitors are used to treat numerous malignancies but may be associated with severe adverse events. Bullous dermatoses, chiefly bullous pemphigoid (BP), are potentially progressive adverse events that cause blistering skin lesions and may involve a significant body surface area. Herein, we report an 87-year-old man with urothelial cell carcinoma undergoing atezolizumab treatment who presented with an acute-onset blistering eruption. Biopsy revealed a subepidermal bulla, direct immunofluorescence revealed linear IgG and C3 deposits at the dermal-epidermal junction, and serum studies reve...
Source: Dermatol Online J - October 14, 2019 Category: Dermatology Authors: Kosche C, Owen JL, Sadowsky LM, Choi JN Tags: Dermatol Online J Source Type: research

[Penile malakoplakia associated with lichen sclerosus].
CONCLUSION: We report a case of penile malakoplakia associated with chronic E. coli urinary tract infection, due originally to associated genital lichen sclerosus. PMID: 31627929 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - October 14, 2019 Category: Dermatology Authors: Amsellem J, Corgibet F, Ponnelle T, Dauendorffer JN Tags: Ann Dermatol Venereol Source Type: research

Osteoporotic vertebral fracture caused by topical corticosteroid abuse: A case report.
Authors: Piaserico S, Linder D, Messina F, Alaibac M Abstract In the present case report, a 32-year-old man with a 20-year long history of psoriasis, who presented with severe lower back pain and had no records of previous trauma, is reported. The patient reported the regular use of clobetasol cream, for 8 years, at an average dosage of 100 grams (g) per week. At the time of visit, the patient presented with severe psoriasis, which was associated with a cushingoid appearance. An X-ray of the spine was performed and the results revealed diffuse vertebral collapse that was caused by osteoporosis. The patient was diag...
Source: Experimental and Therapeutic Medicine - October 2, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

A review of topical corticosteroid sprays for the treatment of inflammatory dermatoses
Background: Topical corticosteroids are available in many vehicles. However, patients' preference for vehicles are variable and could be tailored to maximize patient adherence. Spray vehicles may offer, convenience, and strong efficacy. Methods: A literature review was conducted using keywords: clobetasol, desoximetasone, betamethasone, triamcinolone, corticosteroid, topical, spray, vehicles, treatment, and clinical trial. Results: For moderate-to-severe plaque psoriasis, 87% of subjects achieved an Overall Disease Severity (ODS) Score ≤2 at week two and 78% achieved an ODS ≤1 after four weeks with clobetasol propion...
Source: Dermatology Online Journal - September 9, 2019 Category: Dermatology Source Type: research

407 Novel transcriptomic network interactions in the human skin treated with topical glucocorticoid
Glucocorticoids (GCs) are the most frequently used anti-inflammatory drugs in dermatology. However, the molecular signature of GCs and their receptor (GR) in human skin is largely unknown. We obtained full thickness skin biopsies from healthy volunteers before and after topical treatment with clobetasol propionate (CBP, 0.05% cream) applied for 24 hrs to the relatively sun-protected volar aspect of the upper arm skin. Our validated bioinformatics analysis of CBP-induced human skin transcriptome (RNASeq) identified numerous novel GC-responsive genes, including over a thousand non-coding RNAs. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - August 31, 2019 Category: Dermatology Authors: I. Budunova, L.N. Lili, A. Klopot, G. Baida, B. Readhead, J.T. Dudley Tags: Innate Immunity and Inflammation Source Type: research