FDA warns about possible increased risk of death and serious side effects with cancer drug Copiktra (duvelisib)
Listen to an audio podcast of the June 30, 2022, FDA Drug Safety Communication. Results from a clinical trial show a possible increased risk of death with Copiktra (active ingredient duvelisib) compared to another medicine to treat leukemia and lymphoma. (Source: FDA Drug Safety Podcasts)
Source: FDA Drug Safety Podcasts - July 27, 2022 Category: Drugs & Pharmacology Authors: U.S. Food and Drug Administration, Center for Drug Evaluation and Research Source Type: podcasts
Can Omecamtiv Mecarbil Improve Peak Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)?
Exercise limitation is a cardinal manifestation of heart failure with reduced ejection fraction (HFrEF), but it is not consistently improved by any of the current guideline-directed medical therapies. JAMA Deputy Editor Gregory Curfman, MD, discusses whether omecamtiv mecarbil can improve peak exercise capacity in patients with HFrEF with Gregory D. Lewis, MD, from Massachusetts General Hospital, and Mark H. Drazner, MD, MSc, from University of Texas Southwestern Medical Center. Related Content: Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Rando...
Source: JAMA Author Interviews - July 19, 2022 Category: General Medicine Authors: JAMA Network Source Type: podcasts
JAMA Surgery : Intraoperative Urinary Catheter Use and Urinary Retention After Laparoscopic Inguinal Hernia Repair
Interview with Aldo Fafaj, MD, author of Effect of Intraoperative Urinary Catheter Use on Postoperative Urinary Retention After Laparoscopic Inguinal Hernia Repair: A Randomized Clinical Trial.Hosted by Amalia Cochran, MD. (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - June 15, 2022 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
Diabetes Core Update Diabetic Neuropathy Part 3 May 2022
In this special three-part series we will be doing a deep dive into diabetic peripheral neuropathy. In this third episode Drs. J. Robinson Singleton and Robin Marcus join our host, Dr. Neil Skolnik to discuss non-pharmacologic treatment of diabetic peripheral neuropathy. In part 1 we covered the epidemiology, pathophysiology, clinical manifestations, screening and diagnosis of diabetic peripheral neuropathy and in part 2 of the series we covered pharmacologic management. This series is supported by an unrestricted educational grant to the American Diabetes Association from Nevro, Inc. Presented by: Neil Skoln...
Source: Diabetes Core Update - May 16, 2022 Category: Endocrinology Authors: American Diabetes Association Source Type: podcasts
TWiV 899: COVID-19 clinical update #114 with Dr. Daniel Griffin
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Effects of early treatment with Ivermectin (NEJM) Procalcitonin not a reliable biomarker (IDSA) Evaluation of vaccine in children 6 t...
Source: This Week in Virology - MP3 Edition - May 14, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
JAMA Oncology : Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma
Interview with David Anthony Palma, MD, PhD, and Anthony C. Nichols, MD, authors of Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial Hosted by Jack West, MD. (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - April 28, 2022 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
JAMA Psychiatry : Augmentation of Cognitive Behavioral Therapy With Transcranial Direct Current Stimulation
Interview with Malek Bajbouj, MD, and Frank Padberg, MD, authors of Efficacy of Augmentation of Cognitive Behavioral Therapy With Transcranial Direct Current Stimulation for Depression: A Randomized Clinical Trial. Hosted by John Torous, MD, MBI. (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - April 20, 2022 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
JAMA Surgery : Comparable Clinical Outcomes of Partial vs Total Fundoplication
Interview with Apostolos Analatos, MD, and Anders Thorell, MD, PhD, authors of Clinical Outcomes of a Laparoscopic Total vs a 270° Posterior Partial Fundoplication in Chronic Gastroesophageal Reflux Disease: A Randomized Clinical Trial. Hosted by Amalia Cochran, MD. (Source: JAMA Specialty Journals Author Interviews)
Source: JAMA Specialty Journals Author Interviews - April 20, 2022 Category: General Medicine Authors: The JAMA Network Source Type: podcasts
Why do naked mole rats live as long as giraffes?
00:54 How Mammals’ mutation rates affects their lifespanFor biologists, a long-standing question has been why some animals live longer than others. This week a team have attempted to answer this, by measuring the rates that different animal species accumulate mutations. They show that longer-lived animals acquire mutations at a slower rate, which helps to explain why cancer risk does not scale with lifespan.Research article: Cagan et al.News and Views: Mutational clocks tick differently across species07:56 Research HighlightsA clinical trial suggests a change to the treatment of a pregnancy ailment, and astronomers ident...
Source: Nature Podcast - April 13, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 883: COVID-19 clinical update #108 with Dr. Daniel Griffin
In COVID-19 clinical update #107, Daniel Griffin reviews vaccine booster doses, at-home testing, transmission in ferrets, improving indoor air quality, trials of BCG, ivermectin, and fluvoxamine, vaccination during pregnancy, mRNA vaccines and Fc functions, anti-platelet and aspirin therapy and a trial of prone positioning. Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode FDA authorizes second booster (FDA) Second booster and mortality (Res Square) Booster effectiveness vs hospitalization (MMWR) SARS-CoV-2 confections (Lancet) At-home testing (MMWR) Transm...
Source: This Week in Virology - MP3 Edition - April 2, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
The challenges of testing medicines during pregnancy, and when not paying attention makes sense
On this week’s show: Getting pregnant people into clinical trials, and tracking when mice aren’t paying attention
First up, Staff Writer Jennifer Couzin-Frankel joins host Sarah Crespi to discuss how scientists can overcome the lack of research on drug safety in pregnancy.
Next, Nikola Grujic, a Ph.D. student at the Institute for Neuroscience at ETH Zürich, talks about rational inattention in mice and how it helps explain why our brains notice certain things—and miss others.
This week’s episode was produced with help from Podigy.
[Image: Stefan Rotter/iStock; Music: Jeffrey Cook]
[alt: rod...
Source: Science Magazine Podcast - March 17, 2022 Category: Science Authors: Science Magazine Source Type: podcasts
The challenges of testing medicines during pregnancy, and when not paying attention makes sense
On this week’s show: Getting pregnant people into clinical trials, and tracking when mice aren’t paying attention
First up, Staff Writer Jennifer Couzin-Frankel joins host Sarah Crespi to discuss how scientists can overcome the lack of research on drug safety in pregnancy.
Next, Nikola Grujic, a Ph.D. student at the Institute for Neuroscience at ETH Zürich, talks about rational inattention in mice and how it helps explain why our brains notice certain things—and miss others.
This week’s episode was produced with help from Podigy.
[Image: Stefan Rotter/iStock; Music: Jeffrey Cook]
[alt: rodent peering out of a...
Source: Science Magazine Podcast - March 17, 2022 Category: Science Authors: Science Magazine Source Type: podcasts
The coin toss of Alzheimer's inheritance
Marty Reiswig is fit and healthy, but every two weeks he is injected with the experimental drug gantenerumab and has monthly MRI scans. He submits to this because a rare genetic mutation runs in his family that predisposes them to early-onset Alzheimer’s disease.We spoke to him about his experience on the trial, and why he chose to continue trialling the drug even after formal clinical trials were discontinued.Produced and narrated by Lorna Stewart.More on this story:News Feature: Could drugs prevent Alzheimer’s? These trials aim to find outResources for those affected by Alzheimer's:Alzheimer's associationAlzheimers.g...
Source: Nature Podcast - March 17, 2022 Category: Science Authors: Springer Nature Limited Source Type: podcasts
