Derivative of 7-hydroxycoumarin has antifungal potential against Candida species and low cytotoxicity against human cells: In silico studies and biological evaluation
This study investigates the antifungal and cytotoxic properties of 7-(pentyloxy)-2H-chromen-2-one. Through molecular docking and dynamics simulations, we explored the compound's interactions with fungal cell protein targets. Notably, it exhibited strong affinities for 1,3β-glucan synthase, squalene epoxidase, δ-14-sterol reductase, 14-α-demethylase, and thymidylate synthase, with binding energies ranging from -100.39 to -73.15 kcal/mol. Molecular dynamics simulations confirmed its stable binding at active targets. The MIC and MFC values ranged from 67.16 μM (15.6 μg/mL) to 537.28 μM (125.0 μg/mL). The compound displ...
Source: Mol Biol Cell - December 14, 2023 Category: Molecular Biology Authors: Paula Lima Nogueira Danielle da N óbrega Alves Palloma Christine Queiroga Gomes da Costa Gleycyelly Rodrigues Araujo Alana Rodrigues Ferreira Ana Paula Gomes Moura Farias Nat ália Ferreira de Sousa Marianna Vieira Sobral Dami ão Pergentino de Sousa Mar Source Type: research
Culture media influences Candida parapsilosis growth, susceptibility, and virulence
This study provides valuable insights into the intricate interplay between nutrient availability and C. parapsilosis pathogenicity. It emphasizes the importance of considering pathogen behavior in diverse conditions when designing research protocols and therapeutic strategies. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - December 13, 2023 Category: Microbiology Source Type: research
Molecules, Vol. 28, Pages 7919: Helium Cold Atmospheric Plasma Causes Morphological and Biochemical Alterations in Candida albicans Cells
Conclusions: Helium-CAP caused morphological and topographic alterations in C. albicans cells and affected the cell wall polysaccharide content. (Source: Molecules)
Source: Molecules - December 3, 2023 Category: Chemistry Authors: Sabrina de Moura Rovetta-Nogueira Aline Chiodi Borges Maur ício de Oliveira Filho Thalita Mayumi Castaldelli Nishime Luis Rogerio de Oliveira Hein Konstantin Georgiev Kostov Cristiane Yumi Koga-Ito Tags: Article Source Type: research
EE333 Cost-Effectiveness of Once-Weekly Rezafungin for the Treatment of Candidemia and Invasive Candidiasis in the UK
This study assessed the cost-effectiveness of rezafungin versus daily echinocandins for the treatment of C/IC from UK healthcare perspective. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: N. Muszbek, A. Angdembe, C. Garcia-Vidal, I. Bielicka, K. Abrams, K. Tolley, M. Ruhnke, M. Lebmeier, N. Hawkins, N. Manamley, S. Dickerson Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: Anne-Lise Bienvenu V éronique Leray C éline Guichon St éphanie Bourget Claire Chapuis Am élie Duréault Patricia Pavese Sandrine Roux Elham Kahale Wajih Chaabane Fabien Subtil Delphine Maucort-Boulch Fran çois Talbot Xavier Dode Herv é Ghesquières Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: Anne-Lise Bienvenu V éronique Leray C éline Guichon St éphanie Bourget Claire Chapuis Am élie Duréault Patricia Pavese Sandrine Roux Elham Kahale Wajih Chaabane Fabien Subtil Delphine Maucort-Boulch Fran çois Talbot Xavier Dode Herv é Ghesquières Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: Anne-Lise Bienvenu V éronique Leray C éline Guichon St éphanie Bourget Claire Chapuis Am élie Duréault Patricia Pavese Sandrine Roux Elham Kahale Wajih Chaabane Fabien Subtil Delphine Maucort-Boulch Fran çois Talbot Xavier Dode Herv é Ghesquières Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: A-L Bienvenu V Leray C Guichon S Bourget C Chapuis A Dur éault P Pavese S Roux E Kahale W Chaabane F Subtil D Maucort-Boulch F Talbot X Dode H Ghesqui ères G Leboucher Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: A-L Bienvenu V Leray C Guichon S Bourget C Chapuis A Dur éault P Pavese S Roux E Kahale W Chaabane F Subtil D Maucort-Boulch F Talbot X Dode H Ghesqui ères G Leboucher Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: A-L Bienvenu V Leray C Guichon S Bourget C Chapuis A Dur éault P Pavese S Roux E Kahale W Chaabane F Subtil D Maucort-Boulch F Talbot X Dode H Ghesqui ères G Leboucher Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: A-L Bienvenu V Leray C Guichon S Bourget C Chapuis A Dur éault P Pavese S Roux E Kahale W Chaabane F Subtil D Maucort-Boulch F Talbot X Dode H Ghesqui ères G Leboucher Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: A-L Bienvenu V Leray C Guichon S Bourget C Chapuis A Dur éault P Pavese S Roux E Kahale W Chaabane F Subtil D Maucort-Boulch F Talbot X Dode H Ghesqui ères G Leboucher Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: A-L Bienvenu V Leray C Guichon S Bourget C Chapuis A Dur éault P Pavese S Roux E Kahale W Chaabane F Subtil D Maucort-Boulch F Talbot X Dode H Ghesqui ères G Leboucher Source Type: research
ANTIFON-CLIC ®, a new clinical decision support system for the treatment of invasive aspergillosis: is it clinically relevant?
CONCLUSIONS: This new CDSS dedicated to IA is meeting the clinical practice. Its implementation in routine will help to support antifungal stewardship.PMID:38000506 | DOI:10.1016/j.pharma.2023.11.002 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - November 24, 2023 Category: Drugs & Pharmacology Authors: A-L Bienvenu V Leray C Guichon S Bourget C Chapuis A Dur éault P Pavese S Roux E Kahale W Chaabane F Subtil D Maucort-Boulch F Talbot X Dode H Ghesqui ères G Leboucher Source Type: research
Implications of empirical administration of caspofungin in COVID-19 complicated fungal infections
(Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - November 21, 2023 Category: Microbiology Source Type: research
