Candida palmioleophila candidemia and bacterial co-infection in a 3-month-old infant with biliary atresia
Candidemia caused by rare and uncommon Candida species is becoming more prevalent in pediatric healthcare settings, resulting in significant morbidity and mortality. One such species, Candida palmioleophila, is resistant to fluconazole but highly susceptible to echinocandins. Here, we report the first documented case of C. palmioleophila candidemia in Iran that occurred in a male infant with biliary atresia who had been hospitalized for 2 months. The patient’s blood and urine cultures were positive for both yeast and bacterial species. Through DNA sequence analysis, the yeast isolate was identified as C. palmioleophila. ...
Source: Frontiers in cellular and infection microbiology - November 2, 2023 Category: Microbiology Source Type: research
A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study
CONCLUSIONS: This study will describe whether contemporary antifungal drug dosing achieves drug exposures associated with optimal outcomes. Data will also be used for the development of antifungal dosing algorithms for critically ill patients. Optimised drug dosing should be considered a priority for improving clinical outcomes for critically ill patients with fungal infections.PMID:37876989 | PMC:PMC10581271 | DOI:10.1016/j.ccrj.2023.04.002 (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - October 25, 2023 Category: Intensive Care Authors: Jason A Roberts Fekade Sime Jeffrey Lipman Maria Patricia Hern ández-Mitre Jo ão Pedro Baptista Roger J Br üggemann Jai Darvall Jan J De Waele George Dimopoulos Jean-Yves Lefrant Mohd Basri Mat Nor Jordi Rello Leonardo Seoane Monica A Slavin Miia Valko Source Type: research
