A Phase I/II Clinical Trial to evaluate the efficacy of baricitinib to prevent respiratory insufficiency progression in onco-hematological patients affected with COVID19: A structured summary of a study protocol for a randomised controlled trial
AbstractObjectivesBaricitinib is supposed to have a double effect on SARS-CoV2 infection. Firstly, it reduces the inflammatory response through the inhibition of the Januse-Kinase signalling transducer and activator of transcription (JAK-STAT) pathway. Moreover, it reduces the receptor mediated viral endocytosis by AP2-associated protein kinase 1 (AAK1) inhibition. We propose the use of baricinitib to prevent the progression of the respiratory insufficiency in SARS-CoV2 pneumonia in onco-haematological patients. In this phase Ib/II study, the primary objective in the safety cohort is to describe the incidence of severe adv...
Source: Trials - February 5, 2021 Category: Research Source Type: clinical trials
Left Atrial Posterior Wall and PV Isolation Using Cryoballoon for Treatment of Persistent AF
Condition: Persistent Atrial Fibrillation Interventions: Procedure: Standard Cryoballoon Pulmonary Vein Isolation (PVI); Device: Cryoballoon PVI + Posterior Wall Isolation Sponsors: Dignity Health Medical Foundation; Mercy General Hospital and Dignity Health Medical Foundation; St. Thomas Heart; Stanford University; UCLA Cardiac Arrhythmia Center; Beth Israel Deaconess Medical Center; Albert Einstein College of Medicine and Montefiore Medical Center; UC Health Medical Center; Staten Island University Hospital; MedStar Georgetown University Hospital and Medical Cen...
Source: ClinicalTrials.gov - August 10, 2020 Category: Research Source Type: clinical trials
Accuracy of Rhythm Detection by a Wearable Smart Watch for Cardiac Arrhythmias (The WATCH-RHYTHM Study)
Condition: Atrial Fibrillation Intervention: Other: AFib detection with wearable smart watch Sponsor: Kansas City Heart Rhythm Research Foundation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 5, 2020 Category: Research Source Type: clinical trials
