2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device
DiscussionThe proposed trial will test the hypothesis that 2-HOBA reduces post-ablation atrial arrhythmias through sequestration of reactive IsoLG species. The results of this study may improve the understanding of the role of IsoLGs and oxidative stress in AF pathogenesis and provide evidence to advance 2-HOBA and related compounds as a new therapeutic strategy to treat AF.Trial registrationClinicalTrials.govNCT04433091. Registered on June 3, 2020. (Source: Trials)
Source: Trials - August 28, 2021 Category: Research Source Type: clinical trials

Therapy Strategies After LAA Occluder Device Embolization
Conditions:   Left Atrial Appendage Occluder;   Device Embolisation;   Therapy Strategies;   Risk Factors Intervention:   Procedure: Removal or leaving of LAA occluders Sponsors:   Cardiovascular Center Frankfurt;   Kerstin Piayda, CardioVascular Center Frankfurt, Frankfurt, Germany;   Kolja Sievert, CardioVascular Center Frankfurt, Frankfurt, Germany;   Roberto Galea, Universitätsspital Bern, Bern, Switzerland;   Moniek Maarse, St. Antonius Ziekenhuis, Nieuwegein, Netherlands;   Ainars Rudzitis, P. Stradins Clinical University Hospital, Riga, Lettland;   Jacob Pontoppidan, Odense University Hosp...
Source: ClinicalTrials.gov - August 20, 2021 Category: Research Source Type: clinical trials