Rapid determination of nine barbiturates in human whole blood by liquid chromatography‐tandem mass spectrometry
A rapid, simple and sensitive liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method was developed for the qualitative and quantitative analysis of nine barbiturates (barbital, phenobarbital, pentobarbital, amobarbital, secobarbital, thiopental, butalbital, butabarbital, and hexobarbital) in human whole blood. Barbiturates were extracted from 100 μL of human whole blood samples using a simple liquid‐liquid extraction (LLE) procedure, and detected by LC‐MS/MS. An UPLC C18 (2.1 mm × 100 mm, 1.7 µm) column was used at 40 °C for the separation and acetonitrile/water system was used as the mo...
Source: Drug Testing and Analysis - June 30, 2016 Category: Drugs & Pharmacology Authors: Xinyu Zhang, Zebin Lin, Jiaolun Li, Zhibin Huang, Yulan Rao, Hao Liang, Jie Yan, Feng Zheng Tags: Research article Source Type: research
Medication Overuse Headache Due to Butalbital, Acetaminophen, and Caffeine Tablets.
Authors: Feeney R
Abstract
Questions from patients about pain conditions and analgesic pharmacotherapy and responses from authors are presented to help educate patients and make them more effective self-advocates. Medication overuse headache is a relatively common cause for chronic daily headache in the migraine patient. In reply to a question, medication overuse headache is reviewed, acute and preventive medications are discussed, and quality of life is considered.
PMID: 27159186 [PubMed - as supplied by publisher] (Source: Journal of Pain and Palliative Care Pharmacotherapy)
Source: Journal of Pain and Palliative Care Pharmacotherapy - May 11, 2016 Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research
Managing Migraine During Pregnancy and Lactation
Abstract
While over half of women with migraine report improvement during pregnancy, having a history of migraine may increase the chance of negative health outcomes. The state of pregnancy increases the risk of several dangerous secondary headache disorders, especially those associated with hypertensive disorders of pregnancy, and providers need to know the red flags to diagnose and treat emergently. Non-pharmacological migraine treatments can be instituted in advance of pregnancy as many are considered the safest options during pregnancy, but understanding the safety of medications and dietary supplem...
Source: Current Neurology and Neuroscience Reports - March 21, 2016 Category: Neuroscience Source Type: research
Therapeutic Drug Monitoring of Pentobarbital: Experience at an Academic Medical Center
Conclusions: Pentobarbital TDM can be performed by immunoassay on an automated clinical chemistry platform, providing an alternative to chromatography-based methods. Confusion in barbiturate names is common, especially pentobarbital and phenobarbital. (Source: Therapeutic Drug Monitoring)
Source: Therapeutic Drug Monitoring - November 17, 2015 Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Application of data screening to drug exposure in large risk factor studies of birth defects
ConclusionWhile screening programs such as the one described can be a valuable tool for exploring potential associations in large data bases, they must be applied with caution. The issue of multiple testing and chance findings is a major concern. While statistics are a necessary component, human judgment must be an integral part of the process. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 1, 2015 Category: Perinatology & Neonatology Authors: Carol Louik, Martha Werler, Marlene Anderka, Allen A. Mitchell Tags: Original Research Article Source Type: research
Migraine Diagnosis and Treatment: A Knowledge and Needs Assessment among Primary Care Providers (S23.006)
Conclusions: PCPs may not be aware of the specific recommendations for managing migraine patients. Future work should focus on innovative ways to provide decision support and education to PCPs who are caring for patients with migraine.Disclosure: Dr. Minen has nothing to disclose. Dr. Tishler has nothing to disclose. Dr. Loder has received personal compensation in an editorial capacity for British Medical Journal. Dr. Silbersweig has nothing to disclose. (Source: Neurology)
Source: Neurology - April 8, 2015 Category: Neurology Authors: Minen, M., Tishler, L., Loder, E., Silbersweig, D. Tags: Headache: Epidemiology and Clinical Source Type: research
The Acute Treatment of Migraine in Adults: The American Headache Society Evidence Assessment of Migraine Pharmacotherapies
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify articles related to acute ...
Source: Headache: The Journal of Head and Face Pain - January 20, 2015 Category: Neurology Authors: Michael J. Marmura, Stephen D. Silberstein, Todd J. Schwedt Tags: American Headache Society Evidence Assessment Source Type: research
The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies.
Abstract
The study aims to provide an updated assessment of the evidence for individual pharmacological therapies for acute migraine treatment. Pharmacological therapy is frequently required for acutely treating migraine attacks. The American Academy of Neurology Guidelines published in 2000 summarized the available evidence relating to the efficacy of acute migraine medications. This review, conducted by the members of the Guidelines Section of the American Headache Society, is an updated assessment of evidence for the migraine acute medications. A standardized literature search was performed to identify ...
Source: Headache - January 1, 2015 Category: Neurology Authors: Marmura MJ, Silberstein SD, Schwedt TJ Tags: Headache Source Type: research
Butalbital and Pediatric Headache: Stay off the Downward Path.
Abstract
Despite limited evidence from the literature surrounding safety or efficacy, butalbital-containing medicines (BCMs) have maintained their rank as "go-to" prescribed migraine and headache relief drugs in the United States, despite bans on these barbiturates in Germany and other European countries. Providers at the Pediatric Headache Program at Boston Children's Hospital recommend that clinicians prescribe triptan-based medications instead of BCMs, given the known negative side effects of BCMs on the general population, and the uncertain longitudinal trajectory of BCMs on developing brains.
...
Source: Headache - December 23, 2014 Category: Neurology Authors: Caruso A, Lazdowsky L, Rabner J, Haberman J, LeBel A Tags: Headache Source Type: research
Butalbital and Pediatric Headache: Stay off the Downward Path
Despite limited evidence from the literature surrounding safety or efficacy, butalbital‐containing medicines (BCMs) have maintained their rank as “go‐to” prescribed migraine and headache relief drugs in the United States, despite bans on these barbiturates in Germany and other European countries. Providers at the Pediatric Headache Program at Boston Children's Hospital recommend that clinicians prescribe triptan‐based medications instead of BCMs, given the known negative side effects of BCMs on the general population, and the uncertain longitudinal trajectory of BCMs on developing brains. (Source: Headache: The J...
Source: Headache: The Journal of Head and Face Pain - December 23, 2014 Category: Neurology Authors: Alessandra Caruso, Lori Lazdowsky, Jonathan Rabner, Jason Haberman, Alyssa LeBel Tags: Vox Clamantis Source Type: research
Evaluating the safety and tolerability profile of acute treatments for migraine
Publication date: March 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 1 Author(s): Vincent T. Martin , James A. Goldstein Among the medications that have been used as acute treatments for migraine are nonspecific agents, including nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics (either single or combination), and narcotics, as well as migraine-specific medications, including ergot alkaloids and triptans (5-hydroxytryptamine 1B/1D agonists). All of these drugs have side effects that vary in type and severity. Side effects of nonspecific medications, including gastrointestin...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research
Evaluation of Headache Severity after Aneurysmal Subarachnoid Hemorrhage
Conclusions Headache after SAH is persistent and treatment refractory. There may be an association with development of vasospasm and worsening of headache. Novel treatment strategies to attenuate headache in this population are needed. Graphical abstract (Source: Interdisciplinary Neurosurgery)
Source: Interdisciplinary Neurosurgery - November 3, 2014 Category: Neurosurgery Source Type: research
Intranasal Capsaicin (IC) Rapidly Relieves the Pain of Migraine and Other Severe Headaches (P7.179)
CONCLUSIONS: IC may be an option for rapid analgesia in a range of headache disorders. Nasal sting was not a deterrent for use if IC was perceived effective.Study Supported by: VR1 Inc.Disclosure: Dr. Alexianu has nothing to disclose. Dr. Chatterjee has received personal compensation for activities with VR1 Inc. as an employee. Dr. Chatterjee holds stock and/or stock options in VR1 Inc., which sponsored research in which Dr. Chatterjee was involved as an investigator. (Source: Neurology)
Source: Neurology - April 9, 2014 Category: Neurology Authors: Alexianu, M., Chatterjee, A. Tags: Headache: Treatment Source Type: research
Should Butalbital Ever Be Given, Much Less to a Pregnant Woman?
(Source: Headache: The Journal of Head and Face Pain)
Source: Headache: The Journal of Head and Face Pain - January 8, 2014 Category: Neurology Authors: Deborah E. Tepper Tags: Guest Editorial Source Type: research
Should butalbital ever be given, much less to a pregnant woman?
PMID: 24400754 [PubMed - in process] (Source: Headache)
Source: Headache - January 1, 2014 Category: Neurology Authors: Tepper DE Tags: Headache Source Type: research
