Drugs for Migraine
Date: October 5, 2020
Issue #:
1608Summary:
An oral nonopioid analgesic is often sufficient for acute
treatment of mild to moderate migraine headache
without severe nausea or vomiting. A triptan is the
drug of choice for treatment of moderate to severe
migraine headache pain in most patients without
vascular disease. Early treatment of pain when it is
still mild to moderate in intensity improves headache
response and reduces the risk of recurrence. (Source: The Medical Letter)
Source: The Medical Letter - August 18, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Acetaminophen acupuncture Aimovig Ajovy Almotriptan Amerge Amitriptyline Antidepressants Antiepileptics Aspirin Atenolol Aventyl Beta blockers Bisoprolol Botox Botulinum toxin Butalbital Cafergot Caffeine Cambia Can Source Type: research
Epidemiology and Treatment of Menstrual Migraine and Migraine During Pregnancy and Lactation: A Narrative Review.
Abstract
The peak prevalence of migraine occurs in women of reproductive age, and women experience a higher burden of migraine symptoms and disability compared to men. This increased burden of migraine in women is related to both developmental and temporally variable activational effects of female sex hormones. Changing levels of female sex hormones affect the expression of migraine during pregnancy, and, to a lesser degree, lactation, and are the mechanism underlying menstrual migraine. This review describes the evidence for sex differences in the expression of migraine across the reproductive epoch; revi...
Source: Headache - October 2, 2019 Category: Neurology Authors: Burch R Tags: Headache Source Type: research
Headache in Pregnancy and the Puerperium
Migraine is the most common cause of headache during pregnancy. Pregnancy increases risk for many causes of headache, including pathologic vascular processes. Headache associated with neurologic signs or symptoms or that is progressive and refractory to treatment; acute in onset; and severe, postural, or different from typical headaches should be evaluated. Work-up should include cerebral and cerebrovascular imaging and monitoring for hypertension. Acetaminophen is first-line symptomatic treatment during pregnancy, and evidence supports triptans rather than butalbital combination analgesics as second-line treatment. Propra...
Source: Neurologic Clinics - November 21, 2018 Category: Neurology Authors: Rebecca Burch Source Type: research
Migraine Treatment in Pregnant Women Presenting to Acute Care: A Retrospective Observational Study.
CONCLUSIONS: While the majority of pregnant women with acute migraine received medications considered relatively safe in pregnancy, there was variation in treatment choice and sequence. Some acute medications considered potentially hazardous for fetal health and less effective for migraine (opioids and butalbital) were used frequently, whereas other treatments that may have low teratogenic risk (nerve blocks, IV fluid boluses, and triptans) were used less or not at all. These results indicate a need for developing guidelines and protocols to standardize acute treatment of migraine in pregnancy.
PMID: 30403400 [PubM...
Source: Headache - November 7, 2018 Category: Neurology Authors: Hamilton KT, Robbins MS Tags: Headache Source Type: research
Migraine Treatment in Pregnant Women Presenting to Acute Care: A Retrospective Observational Study
ConclusionsWhile the majority of pregnant women with acute migraine received medications considered relatively safe in pregnancy, there was variation in treatment choice and sequence. Some acute medications considered potentially hazardous for fetal health and less effective for migraine (opioids and butalbital) were used frequently, whereas other treatments that may have low teratogenic risk (nerve blocks, IV fluid boluses, and triptans) were used less or not at all. These results indicate a need for developing guidelines and protocols to standardize acute treatment of migraine in pregnancy. (Source: Headache: The Journal...
Source: Headache: The Journal of Head and Face Pain - November 7, 2018 Category: Neurology Authors: Katherine T. Hamilton,
Matthew S. Robbins Tags: Research Submission Source Type: research
Headache in Pregnancy
This article reviews the importance of proper diagnosis, natural history, and management of headache disorders in pregnant and postpartum women.
RECENT FINDINGS
Red flags for secondary headache specifically among pregnant women include elevated blood pressure and lack of a previous headache history, as well as a prolonged duration of the headache attack in those with a prior history of migraine. Migraine improvement is typical for most pregnant women, but the prognosis for women who have migraine with aura or chronic migraine is less predictable. Migraine is now an established risk factor for the development of preeclam...
Source: CONTINUUM: Lifelong Learning in Neurology - August 1, 2018 Category: Neurology Tags: Review Articles Source Type: research
Evaluating the safety and tolerability profile of acute treatments for migraine
Publication date: March 2005Source: The American Journal of Medicine Supplements, Volume 118, Supplement 1Author(s): Vincent T. Martin, James A. GoldsteinAmong the medications that have been used as acute treatments for migraine are nonspecific agents, including nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics (either single or combination), and narcotics, as well as migraine-specific medications, including ergot alkaloids and triptans (5-hydroxytryptamine 1B/1D agonists). All of these drugs have side effects that vary in type and severity. Side effects of nonspecific medications, including gastrointestinal (GI) a...
Source: The American Journal of Medicine Supplements - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Extracorporeal elimination of butalbital in acute aspirin –butalbital–caffeine–codeine (Fiorinal with Codeine) poisoning
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - November 10, 2017 Category: Toxicology Authors: Janelle O. Poyant Robert Albright Jeremy Clain Govind Pandompatam Erin F. Barreto Source Type: research
FDA Warns Against Use of Codeine and Tramadol in Children and Breastfeeding Women
Date: May 22, 2017
Issue #:
1521Summary:
The FDA has issued new warnings about the use of the
opioid analgesics codeine and tramadol in children,
particularly those<12 years old, and in breastfeeding
women due to concerns about the risk of respiratory
depression and death. The FDA previously issued
warnings about these drugs in 2013 and 2015. (Source: The Medical Letter)
Source: The Medical Letter - May 1, 2017 Category: Drugs & Pharmacology Authors: admin Tags: Acetaminophen Aspirin Butalbital Capital carisoprodol Chlorpheniramine CoActifed Codeine ConZip Dextromethorphan Durela Fioricet Fiorinal Hydrocodone Morphine NSAIDs Ofirmev Pain Phenylephrine Promethazine pseudoeph Source Type: research
Rapid determination of nine barbiturates in human whole blood by liquid chromatography ‐tandem mass spectrometry
A rapid, simple and sensitive liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method was developed for the qualitative and quantitative analysis of nine barbiturates (barbital, phenobarbital, pentobarbital, amobarbital, secobarbital, thiopental, butalbital, butabarbital, and hexobarbital) in human whole blood. Barbiturates were extracted from 100 μL of human whole blood samples using a simple liquid‐liquid extraction (LLE) procedure, and detected by LC‐MS/MS. An UPLC C18 (2.1 mm × 100 mm, 1.7 µm) column was used at 40 °C for the separation and acetonitrile/water system was used as the mo...
Source: Drug Testing and Analysis - June 30, 2016 Category: Drugs & Pharmacology Authors: Xinyu Zhang, Zebin Lin, Jiaolun Li, Zhibin Huang, Yulan Rao, Hao Liang, Jie Yan, Feng Zheng Tags: Research article Source Type: research
