Pyrotinib Combined With Capecitabine and Bevacizumab for Patients With HER2 Positive Breast Cancer and Brain Metastases
Conditions: Breast Cancer With Brain Metastases Interventions: Drug: pyrotinib+capecitabine+bevacizumab Sponsors: Tongji Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 1, 2023 Category: Research Source Type: clinical trials
The RESBIOP-study: Resection Versus Biopsy in High-grade Glioma Patients (ENCRAM 2202)
Conditions: Glioblastoma; Glioblastoma, IDH-wildtype; Glioblastoma Multiforme; Glioblastoma Multiforme, Adult; Glioblastoma Multiforme of Brain Interventions: Procedure: Tumor resection; Procedure: Tumor biopsy Sponsors: Jasper Gerritsen; Haaglanden Medical Centre; Universitaire Ziekenhuizen KU Leuven; University Hospital Heidelberg; Technical University of Munich; Insel Gruppe AG, University Hospital Bern; Massachusetts General Hospital; University of California, San Francisco Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 27, 2023 Category: Research Source Type: clinical trials
Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis
Conditions: Breast Carcinoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Neoplasm in the Leptomeninges Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Radiation: Radiation Therapy; Procedure: Resection; Drug: Trotabresib; Drug: Vinorelbine Sponsors: Northwestern University; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 17, 2023 Category: Research Source Type: clinical trials
A Study of Cabozantinib and Nivolumab With Radiation Therapy for People With Renal Cell Carcinoma That Has Spread to the Brain
Conditions: Metastatic Renal Cell Carcinoma; Brain Metastases Interventions: Drug: Cabozantinib; Device: Nivolumab; Radiation: Stereotactic Radiosurgery (SRS) Sponsors: Memorial Sloan Kettering Cancer Center; Exelixis Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial
Conditions: Low Grade Glioma; Malignant Brain Glioma; Malignant Brain Neoplasm; Meningioma Interventions: Procedure: Biospecimen Collection; Procedure: Computed Tomography; Drug: Dexamethasone; Procedure: Magnetic Resonance Imaging; Other: Questionnaire Administration Sponsors: Emory University; National Cancer Institute (NCI) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
Study of Oral JYP0322 in Patients With Locally Advanced or Metastatic Cancer Targeting ROS1 Molecular Fusion.
Conditions: Protein Kinase Inhibitors; Other Protocol Specified Criteria; Lung Neoplasms; Brain Neoplasms Interventions: Drug: JYP0322 Sponsors: Guangzhou JOYO Pharma Co., Ltd Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials
Clinical Feasibility of Brain Radiotherapy Using Synthetic CTs in an MRI-only Workflow
Conditions: Brain Tumor, Primary; Brain Tumor - Metastatic Interventions: Radiation: brain radiotherapy Sponsors: University of Erlangen-N ürnberg Medical School Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 30, 2023 Category: Research Source Type: clinical trials
A Study of Avutometinib for People With Solid Tumor Cancers
Conditions: Refractory Cancer; CNS Tumors; CNS Tumor, Adult; CNS Tumor, Childhood; MAP Kinase Family Gene Mutation; NF1; Plexiform Neurofibroma; Low-grade Glioma; Optic Pathway Gliomas; Neuroblastoma; Primary Brain Tumor; Solid Tumor; Solid Tumor, Adult; Solid Carcinoma; Central Nervous System Tumor Interventions: Drug: Avutometinib Sponsors: Memorial Sloan Kettering Cancer Center Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 27, 2023 Category: Research Source Type: clinical trials
ASCENT Intervention for Brain Tumor Patients
Conditions: Malignant Brain Tumor; Glioma; Coping Skills; Distress, Emotional Interventions: Behavioral: Psychosocial intervention; Other: Usual supportive care Sponsors: Massachusetts General Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials
Development of MRF for Characterization of Brain Tumors After Radiotherapy
Conditions: Brain Tumor; Brain Necrosis; Brain Metastases Interventions: Procedure: MRF in conjunction with IVIM MRI without contrast Sponsors: Case Comprehensive Cancer Center; The Cleveland Clinic Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 25, 2023 Category: Research Source Type: clinical trials
cCeLL - Ex Vivo (Confocal Fluorescence Endomicroscopy) for Intraoperative Brain Tumor Diagnosis
Conditions: Benign Brain Tumor; Malignant Brain Tumor Interventions: Diagnostic Test: cCeLL Ex Vivo Sponsors: VPIX Medical; Unity Health Toronto; Korea University Anam Hospital; Samsung Medical Center; Seoul National University Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 24, 2023 Category: Research Source Type: clinical trials
Clinical Applicantion of Multi-Tracer PET/MR Imaging in Neurological Disorders/Disease
Conditions: Alzheimer Disease; Parkinson Disease; Epilepsy; Malignant Brain Tumor Interventions: Device: PET/MR Sponsors: Xuanwu Hospital, Beijing; Peking University Cancer Hospital& Institute; Shanghai Zhongshan Hospital; Wuhan TongJi Hospital; Henan Provincial People ' s Hospital; Sun Yat-sen University; Shanghai East Hospital of Tongji University; The First Affiliated Hospital with Nanjing Medical University; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences; Shanghai Jiao Tong University School of Medicine Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 20, 2023 Category: Research Source Type: clinical trials
RE-irradiation of Diffuse MIdline Glioma paTients
Conditions: Diffuse Midline Glioma, H3 K27M-Mutant; Diffuse Intrinsic Pontine Glioma; Diffuse Glioma; Pontine Tumors; Thalamic Tumor; Brain Tumor, Pediatric Interventions: Radiation: Re-irradiation Sponsors: Rigshospitalet, Denmark; Aarhus University Hospital; Sahlgrenska University Hospital, Sweden; Karolinska University Hospital; Radiumhospitalet, Oslo University Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 20, 2023 Category: Research Source Type: clinical trials
Magnetic Resonance Imaging for Improving Knowledge of Brain Tumor Biology in Patients With Resectable Glioblastoma
Conditions: Glioblastoma; Recurrent Glioblastoma; Resectable Glioblastoma Interventions: Procedure: Biospecimen Collection; Procedure: Magnetic Resonance Imaging; Other: Medical Chart Review Sponsors: Jonsson Comprehensive Cancer Center; National Cancer Institute (NCI) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 19, 2023 Category: Research Source Type: clinical trials
A Phase II Study of T-DXd Plus SRT in HER2-positive Breast Cancer Brain Metastases
Conditions: Breast Cancer; Brain Metastases; Radiotherapy Interventions: Drug: Combination use of SRT with T-DXd Sponsors: Fudan University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 18, 2023 Category: Research Source Type: clinical trials
