Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Strength Training and Aerobic Exercise Reduce Cancer Mortality
Researchers here note that undertaking strength training and aerobic exercise acts to reduce mortality due to cancer, to a similar degree as these activities are known to reduce all cause mortality in later life. The mechanisms involved are likely diverse, but it is worth noting that (a) muscle tissue is metabolically active in beneficial ways, such that more muscle is better than less muscle, (b) better immune function is linked to exercise, and immune surveillance is critical to cancer prevention, and (c) exercise helps to reduce chronic inflammation, where chronic inflammation helps to drive the establishment and develo...
Source: Fight Aging! - August 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 19th 2021
In this study, we developed the first epigenetic clock for domesticated sheep (Ovis aries), which can predict chronological age with a median absolute error of 5.1 months. We have discovered that castrated male sheep have a decelerated aging rate compared to intact males, mediated at least in part by the removal of androgens.
Furthermore, we identified several androgen-sensitive CpG dinucleotides that become progressively hypomethylated with age in intact males, but remain stable in castrated males and females. Comparable sex-specific methylation differences in MKLN1 also exist in bat skin and a range of mouse tissu...
Source: Fight Aging! - July 18, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Incontinence Can Affect Anyone Under the Right (or Wrong) Circumstances: Read Matt's Story
Incontinence only affects "old people" so it's not a big deal, right? I've always understood that any adult - even older adults - who find themselves unable to control urine or bowel movements, could struggle with self-esteem and dignity issues due to the stigma that exists. What I didn't realize though, is that there is a significant number of younger adults who, through physical injury, disease, or emotional trauma, experience incontinence. Once I started hearing from some of them, I quickly changed my thinking. After all, your aging father really doesn't need the "shame" of incontinence along with his other challenges, ...
Source: Minding Our Elders - May 13, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Stigma from Urinary Incontinence Barrier for Many Wanting a More Normal Life
Even though modern devices and medicine have helped many people who live with urinary incontinence, many others need to depend on wearing different types of protection. It's really not unusual, yet there's still a terrible stigma that can cause social embarrassment and sometimes abuse.
Read more about this stigma and how we can fight it on Egosancares blog:
Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver and am reading it slowly on purpose...I don't want it to end.” ...Craig William Dayton, Film Composer
Egosan wants to help you live your life fully: Try Ego...
Source: Minding Our Elders - May 12, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Why Do Older Adults Fight Incontinence Protection So Much?
Many older adults have trouble reconciling their need for incontinence protection, even something as simple as a light pad. This stems from our societal emphasis on the fact that only babies are incontinent. Of course, this isn't true. There are many conditions that can render an adult incontinent and age is just one of them.
Continue reading on Egosancares for more insight into this problem with parents who don't realize that they smell of urine so won't do anything to help:
Purchase Minding Our Elders: Caregivers Share Their Personal Stories – paperback or ebook
Egosan wants to help you live your ...
Source: Minding Our Elders - May 10, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Sharing Personal Stories Is a Powerful Way to End Disease Stigma: Read On
Whether you live with mental illness, dementia, a physical disability, or even incontinence, you are bound to face varying degrees of stigma when encountering the greater population. I believe much of this stems from the underlying (and usually unrecognized) read that many people have that this could happen to them or someone they love. In my opinion, the best way to battle this stigma is for brave people to go public with their challenges and show others that we are the same people with or without our disease or injury or simply a different way of functioning.
Read more on Egosancares blog to learn about how...
Source: Minding Our Elders - May 4, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
It's Bladder Cancer Awareness Month: Are You At Risk?
Bladder cancer is not overly common but it's not a rare disease, either. The American Cancer Society estimates that there will be 83,730 new cases this year. While most of them are treatable if caught reasonably early, both the disease and the treatments can involve varying degrees of incontinence.
Continue reading on Egosancare's blog to learn more about the risks and signs of bladder cancer as well as side effects of different treatments:
Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver and am reading it slowly on purpose...I don't want it to end.” ....
Source: Minding Our Elders - May 3, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Beyond CBD: Here come the other cannabinoids, but where ’s the evidence?
In the span of a few years, the component of cannabis called CBD (cannabidiol) went from being a relatively obscure molecule to a healthcare fad that has swept the world, spawning billions in sales, millions of users, CBD workout clothing, pillowcases, hamburgers, ice cream — you name it. The concerns of such a rapid adoption are that enthusiasm might be soaring high above the actual science, and that there are safety issues, such as drug interactions, that are given short shrift in the enthusiasm to treat chronic pain, insomnia, anxiety, and many of the other conditions that CBD is believed to help alleviate.
Cannabis, ...
Source: Harvard Health Blog - March 23, 2021 Category: Consumer Health News Authors: Peter Grinspoon, MD Tags: Complementary and alternative medicine Drugs and Supplements Fatigue Marijuana Pain Management Source Type: blogs
Hormonal therapies for advanced prostate cancer linked to a higher risk of falls and fractures
Falls rank among the top causes of death and injuries among the elderly, and the risk increases significantly in older people being treated for cancer. Now, investigators are reporting that a newer class of drugs for advanced prostate cancer is associated with a significant increase in fall risk.
Called androgen receptor inhibitors, or ARIs, these drugs target testosterone, a hormone that accelerates the growth of prostate tumors. Unlike traditional hormonal treatments that interfere with the body’s ability to make testosterone (known as androgen deprivation therapy, or ADT), ARIs work by preventing testosterone from...
Source: Harvard Health Blog - January 7, 2021 Category: Consumer Health News Authors: Charlie Schmidt Tags: Health Living With Prostate Cancer Prostate Knowledge Treatments HPK Source Type: blogs
Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cancer Survivors Exhibit Greater Risk of New Cancers and Higher Mortality Due to those Cancers
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - December 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Post #52 Overkill: When Modern Medicine Goes Too Far by Paul Offit M.D.
Overkill: When Modern Medicine Goes Too Far by Paul Offit M.D.I am admittedly a huge fanboy of Paul Offit, an infectious disease guru at Children ' s Hospital of Philadelphia, one of the preeminent pediatric hospitals in the world. His latest bookOverall: When Modern Medicine Goes Too Far, is a collection of medical facts that are already known to the well-read individual, but fly in the face of wrongly-held, out-dated, commonly-believed medical concepts. The majority of the incorrect information was previously considered the standard of care, but newer and better science and studies have clearly demonstrate...
Source: A Pediatrician's Blog - September 23, 2020 Category: Pediatrics Source Type: blogs
More Women Are Pursuing Majority-Male Specialties and Changing Patients ’ Perceptions
By AMY E. KRAMBECK, MD
With the exceptions of pediatrics and obstetrics/gynecology, women make up fewer than half of all medical specialists. Representation is lowest in orthopedics (8%), followed by my own specialty, urology (12%). I can testify that the numbers are changing in urology – women are up from just 8% in 2015, and the breakdown in our residency program here at Indiana University is now about 20% of the 5-year program.
One reason for the increase is likely the growth of women in medicine – 60% of doctors under 35 are women, as are more than half of medical school enrollees. I also credit a generat...
Source: The Health Care Blog - June 5, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Physicians Amy Krambeck female physicians majority male specialties Patients Source Type: blogs
Pain from an Unknown Cause
"My left hip has been hurting for a couple years, but it just got really bad in the past few weeks."My patient, who was in her 70s, didn't add much more to the history. No trauma. No fevers. No bowel or bladder problems. No significant past medical history. Her hip just hurt. She thought she needed an x-ray, and one was obtained.The left femoral head didn't look terrible. There was some irregularity, but there were no fractures or significant joint narrowing. This wasn't a case of neglected severe degenerative joint disease or avascular necrosis that needed a hip replacement.Some red flags started to show up t...
Source: Lions and Tigers and Bears - May 1, 2020 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
