Drug treatments for covid-19: living systematic review and network meta-analysis (update), BMJ
Updated review includes results for new interventions (azithromycin, colchicine, interferons, rhG-CSF, tocilizumab) and evidence remdesivir may not reduce mortality or time to symptom resolution; glucocorticoids probably reduce length of ICU stay and increase ventilator-free days BMJ2020; 370 doi: 2 External 0 0 0 https://doi.org/10.1136/bmj.m2980 false https://doi.org/10.1136/bmj.m2980 true false%> (Published 30 July 2020). Cite this as: BMJ 2020;370:m2980. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 21, 2020 Category: Consumer Health News Source Type: news

CAS alert: Azithromycin in the Management of COVID-19 Positive Patients
It is now recommended that azithromycin should NOT be used in the managementof confirmed or suspected COVID-19 infection in hospitalised patients unless there are additional indications for which its (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - December 17, 2020 Category: Drugs & Pharmacology Source Type: news

COVID-19 Therapeutic Alert: Azithromycin in the Management of COVID-19 (SARS-CoV-2) Positive Patients, DHSC
RECOVERY trial showed no significant clinical benefit of either oral or IV azithromycin in patients hospitalised with COVID-19. It is now recommended azithromycin should NOT be used in this population unless there are additional indications for which its use remains appropriate. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 16, 2020 Category: Consumer Health News Source Type: news

Trial of Azithromycin in Severe COVID-19 Patients Finds No Benefit Trial of Azithromycin in Severe COVID-19 Patients Finds No Benefit
A clinical trial of the widely-used antibiotic azithromycin in COVID-19 patients in hospital has found no convincing evidence of benefit, prompting doctors to announce on Monday that they have closed that section of the trial.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - December 15, 2020 Category: Intensive Care Tags: Infectious Diseases News Source Type: news

Vaginal Cleansing Protocol Curbs Deep SSIs After Cesarean Vaginal Cleansing Protocol Curbs Deep SSIs After Cesarean
' We aimed to decrease our SSI rate by 30% by adopting an intervention of cleansing followed by azithromycin, ' Dr Johanna Quist-Nelson said, presenting at the ACOG 2020 virtual meeting.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 8, 2020 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

Mechanism of action of chloroquine/hydroxychloroquine for COVID-19 infection
(Bentham Science Publishers) The recent serious outbreak of Covid19 has required urgent medical treatments for numerous patients. No clinically active vaccines or antiviral agents are available for Covid19. According to several studies, Chloroquine (CQ) and Hydroxychloroquine (HCQ) have shown promises as Covid19 antiviral especially when administered with Azithromycin (AZM). (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - November 30, 2020 Category: Infectious Diseases Source Type: news

General practice asked to help identify potential participants for study evaluating early community treatment for Covid-19, Trials
The PRINCIPLE study is currently evaluating azithromycin and doxycycline added to usual care. People with symptomatic Covid-19 may be eligible if they are over 65 or over 50 with an underlying health condition. People can register and participate in the trial entirely remotely. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 27, 2020 Category: Consumer Health News Source Type: news

Some Patients Have Increase in Cardiac Events With Azithromycin
Risk for cardiac events higher with azithromycin versus amoxicillin in those using QT - prolonging drugs (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - October 8, 2020 Category: Respiratory Medicine Tags: Cardiology, Family Medicine, Geriatrics, Infections, Internal Medicine, Critical Care, Emergency Medicine, Pharmacy, Pulmonology, Journal, Source Type: news

Some Patients Have Increase in Cardiac Events With Azithromycin
THURSDAY, Oct. 8, 2020 -- Patients using QT-prolonging drugs have an increased risk for cardiac events in association with azithromycin versus amoxicillin, according to a study published online Sept. 15 in JAMA Network Open. Haridarshan Patel,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 8, 2020 Category: Pharmaceuticals Source Type: news

Lopinavirritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial, The Lancet
Summary Background Lopinavir –ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity, preclinical studies, and observational studies. Here, we report the results of a randomised trial to assess whether lopinavir–ritonavir improves outcomes in patients admitted to hospital with COVID-19. M ethods In this randomised, controlled, open-label, platform trial, a range of possible treatments was compared with usual care in patients admitted to hospital with COVID-19. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients were randomly allocated to either usual s t...
Source: Current Awareness Service for Health (CASH) - October 6, 2020 Category: Consumer Health News Source Type: news

Potential COVID Drug May Raise Heart Risk: Study
The widely prescribed antibiotic azithromycin is being investigated as a COVID-19 treatment, but a new study warns it could increase the risk of heart problems. (Source: WebMD Health)
Source: WebMD Health - September 21, 2020 Category: Consumer Health News Source Type: news