More about chloroquine and hydroxychloroquine, CEBM
VERDICT:
The hypothesis that the 4-aminoquinolines chloroquine and hydroxychloroquine may be beneficial in the treatment of COVID-19 is a weak one, based on poor mechanistic reasoning and inconsistent results of studies in vitro, in laboratory animals, and in humans. It is likely that even if chloroquine and hydroxychloroquine are effective in COVID-19, the beneficial effects will be small.
The risks of adverse reactions to these drugs may be increased in patients who are acutely ill with severe COVID-19, in many of whom high doses are being used.
Macrolide antibacterial drugs, such as azithromycin, clarithromycin, ery...
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news
CV Toxicity Tied to Azithromycin and/or Hydroxychloroquine
THURSDAY, May 28, 2020 -- Hydroxychloroquine and azithromycin may have a serious adverse impact on the cardiovascular system, according to a research letter published online May 22 in Circulation.
Lee S. Nguyen, M.D., from Sorbonne... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 28, 2020 Category: Pharmaceuticals Source Type: news
Cancer Progression Linked to Increased Risk of Death Within 30 Days of COVID-19 Diagnosis
Disease progression and treatment with hydroxychloroquine and azithromycin were associated with increased all-cause 30-day mortality in patients with cancer compared to patients either in remission or with no evidence of disease, according to data presented during a 2020 ASCO Virtual Scientific Program press briefing. (Source: CancerNetwork)
Source: CancerNetwork - May 28, 2020 Category: Cancer & Oncology Authors: Ryan McDonald Source Type: news
Hydroxychloroquine-azithromycin combo may be potentially lethal: Study
Hydroxychloroquine and azithromycin, alone or in combination, have been proposed for treatment of COVID-19 patients, the researchers said. They explained that reports of potentially lethal acute cardiac proarrhythmogenic effects -- promoting irregular heart rhythms -- have been described mainly with azithromycin but also with hydroxychloroquine. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - May 25, 2020 Category: Pharmaceuticals Source Type: news
Malaria Drug Taken by Trump Is Tied to Increased Risk of Heart Problems and Death in New Study
The drugs did not help coronavirus patients, and should not be used outside clinical trials, researchers said. (Source: NYT Health)
Source: NYT Health - May 22, 2020 Category: Consumer Health News Authors: Denise Grady Tags: Hydroxychloroquine (Drug) Azithromycin (Drug) Drugs (Pharmaceuticals) Coronavirus (2019-nCoV) Malaria Clinical Trials Food and Drug Administration Lancet, The (Journal) Trump, Donald J your-feed-healthcare Source Type: news
President Trump Defends His Hydroxychloroquine Use Amid Concerns, Says ‘So Far I Seem to Be O.K.’
(WASHINGTON) — President Donald Trump emphatically defended himself Tuesday against criticism from medical experts that his announced use of a malaria drug against the coronavirus could spark wide misuse by Americans of the unproven treatment with potentially fatal side effects.
Trump’s revelation a day earlier that he was taking hydroxychloroquine caught many in his administration by surprise and set off an urgent effort by officials to justify his action. But their attempt to address the concerns of health professionals was undercut by the president himself. He asserted without evidence that a study raising a...
Source: TIME: Health - May 20, 2020 Category: Consumer Health News Authors: ZEKE MILLER, MARILYNN MARCHIONE and JONATHAN LEMIRE / AP Tags: Uncategorized COVID-19 Donald Trump News Desk wire Source Type: news
What to Know About Hydroxychloroquine
Here are the facts on hydroxychloroquine, which the president has promoted to fight Covid-19 despite warnings from the F.D.A. that it can cause heart problems. (Source: NYT Health)
Source: NYT Health - May 19, 2020 Category: Consumer Health News Authors: Denise Grady, Katie Thomas, Patrick J. Lyons and Neil Vigdor Tags: Hydroxychloroquine (Drug) Coronavirus (2019-nCoV) Azithromycin (Drug) Drugs (Pharmaceuticals) Preventive Medicine Research Hospitals Clinical Trials Rumors and Misinformation Rheumatoid Arthritis Lupus Erythematosus Food and Drug Adm Source Type: news
Hydroxychloroquine No Aid for COVID - Related Mortality
Hydroxychloroquine alone or with azithromycin associated with abnormal electrocardiogram findings (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 18, 2020 Category: Respiratory Medicine Tags: Cardiology, Infections, Internal Medicine, Critical Care, Emergency Medicine, Pharmacy, Pulmonology, Journal, Source Type: news
Hydroxychloroquine No Aid for COVID-Related Mortality
MONDAY, May 18, 2020 -- Treating hospitalized COVID-19 patients with hydroxychloroquine, azithromycin, or both is not associated with improvements in in-hospital mortality, according to a study published online May 11 in the Journal of the American... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 18, 2020 Category: Pharmaceuticals Source Type: news
NIH Launches Trial of Hydroxychloroquine, Azithromycin for COVID - 19
Trial will enroll 2,000 patients with SARS - COV - 2 who have fever, cough, and/or shortness of breath (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 15, 2020 Category: Respiratory Medicine Tags: Infections, Internal Medicine, Critical Care, Emergency Medicine, Pharmacy, Pulmonology, Institutional, Source Type: news
NIH Launches Trial of Hydroxychloroquine, Azithromycin for COVID-19
FRIDAY, May 15, 2020 -- The National Institute of Allergy and Infectious Diseases (NIAID) announced it is sponsoring a phase 2b clinical trial to evaluate the efficacy and safety of hydroxychloroquine and azithromycin in preventing hospitalization... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 15, 2020 Category: Pharmaceuticals Source Type: news
NIH begins clinical trial of hydroxychloroquine and azithromycin to treat COVID-19
(University of California - San Diego) The NIH has launched a major clinical trial to assess the malaria drug hydroxychloroquine and antibiotic azithromycin as a treatment for COVID-19. The trial will recruit 2,000 participants at 30 sites and is led by Davey Smith, MD, of UC San Diego School of Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 15, 2020 Category: Infectious Diseases Source Type: news
NIH begins clinical trial of hydroxychloroquine and azithromycin to treat coronavirus patients
On Thursday, the NIH announced it has begun a clinical trial testing a combination of the antibiotic azithromycin and the anti-malaria drug hydroxychloroquine in coronavirus patients. (Source: the Mail online | Health)
Source: the Mail online | Health - May 14, 2020 Category: Consumer Health News Source Type: news
NIH to study malaria drug championed by President Trump against COVID-19
The National Institutes of Health (NIH) said on Thursday it began a study to evaluate the combination of antibiotic azithromycin and malaria drug hydroxychloroquine, which was previously touted by U.S. President Donald Trump as a "game changer", for the treatment of COVID-19. (Source: Reuters: Health)
Source: Reuters: Health - May 14, 2020 Category: Consumer Health News Tags: healthNews Source Type: news
NIH begins clinical trial of hydroxychloroquine and azithromycin to treat COVID-19
Study enrolling adults with mild to moderate COVID-19 in the United States. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - May 14, 2020 Category: American Health Source Type: news
