Host succinate is an activation signal for Salmonella virulence during intracellular infection
Key to the success of intracellular pathogens is the ability to sense and respond to a changing host cell environment. Macrophages exposed to microbial products undergo metabolic changes that drive inflammatory responses. However, the role of macrophage metabolic reprogramming in bacterial adaptation to the intracellular environment has not been explored. Here, using metabolic profiling and dual RNA sequencing, we show that succinate accumulation in macrophages is sensed by intracellular Salmonella Typhimurium (S. Tm) to promote antimicrobial resistance and type III secretion. S. Tm lacking the succinate uptake transporter...
Source: ScienceNOW - January 21, 2021 Category: Science Authors: Rosenberg, G., Yehezkel, D., Hoffman, D., Mattioli, C. C., Fremder, M., Ben-Arosh, H., Vainman, L., Nissani, N., Hen-Avivi, S., Brenner, S., Itkin, M., Malitsky, S., Ohana, E., Ben-Moshe, N. B., Avraham, R. Tags: Immunology, Microbiology reports Source Type: news
How to optimise duration of antibiotic treatment in patients with sepsis? BMJ (Clinical research ed.) 371: m4357.
Antibiotics represent the cornerstone of treatment. The Surviving Sepsis Campaign (SSC) consensus guidelines recommend treatment for 7 to 10 days, but this is a weak recommendation. Use of antibiotics risks the emergence of antimicrobial resistance and antibiotic-associated infections, such as Clostridiodes difficile. Patients may suffer from toxic effects of the drugs. Balancing the need to treat severe infections effectively against the risks of overuse of antibiotics is central to the principle of antibiotic stewardship. For severe covid-19, antibiotic stewardship remains important for critically ill patients with pneum...
Source: Current Awareness Service for Health (CASH) - January 8, 2021 Category: Consumer Health News Source Type: news
Wistar reports new class of antibiotics active against a wide range of bacteria
(The Wistar Institute) Wistar Institute scientists have discovered a new class of compounds that uniquely combine direct antibiotic killing of pan drug-resistant bacterial pathogens with a simultaneous rapid immune response for combatting antimicrobial resistance (AMR). These finding were published today inNature. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 23, 2020 Category: Biology Source Type: news
Surveillance of antimicrobial resistance could be more challenging outside of the EU
(Microbiology Society) In a new policy report from the Microbiology Society, experts from around the UK explain the desperate need for long-term and ambitious funding for surveillance and research into antimicrobial resistance (AMR). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 21, 2020 Category: International Medicine & Public Health Source Type: news
Zimbabwe: Zimbabwe's Antimicrobial Resistance Threat to Grow If Not Tackled in a Holistic Manner
[WHO] There is growing evidence of Antimicrobial Resistance (AMR) in Zimbabwe. A study conducted by local epidemiologists following the 2018 cholera outbreak concluded that there had been high incidences of drug resistance which made it difficult to contain the disease using the usual antibiotics. The latter, has been a result of Zimbabweans abusing antibiotics due to unregulated consumption and not completing the full course when prescribed by the doctors. Therefore, Zimbabweans need to stop misusing antibiotic (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - December 15, 2020 Category: African Health Source Type: news
Insecure livelihoods hindering efforts to combat anti-microbial resistance globally
(University of Warwick) Patients living in precarious circumstances are less likely to use antibiotics appropriately according to a new study from the University of Warwick, suggesting that efforts to improve conditions for those with little security in their livelihoods could have an unexpected benefit in helping to tackle antimicrobial resistance globally. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - December 9, 2020 Category: International Medicine & Public Health Source Type: news
Free webinar: Advancing the AMR agenda during COVID-19
(International Vaccine Institute) The International Vaccine Institute (IVI), the International Centre for Antimicrobial Resistance Solutions (ICARS), and the Embassy of Denmark in Korea will co-host a free webinar to share strategic reflections and insights for advancing national prevention/control policies and plans against antimicrobial resistance (AMR). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 1, 2020 Category: International Medicine & Public Health Source Type: news
Covid -19, misinformation, and antimicrobial resistance, BMJ
Article highlights a US study that found 71% of covid-19 patients received antibiotics while only 4% had true bacterial coinfection. It concludes strategies are needed to counter the detrimental effect of misinformation on the use of antimicrobials. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 26, 2020 Category: Consumer Health News Source Type: news
COVID cases surge amid growing threat from antimicrobial resistance – WHO chief
More cases of COVID-19 have been reported in the past four weeks than in the first six months of the pandemic, the UN health agency chief told journalists on Friday as he launched a new report on the threat posed by antimicrobial resistance. (Source: UN News Centre - Health, Poverty, Food Security)
Source: UN News Centre - Health, Poverty, Food Security - November 20, 2020 Category: International Medicine & Public Health Source Type: news
English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR) Report 2019 to 2020
Annual report shows there were an estimated 65,162 antimicrobial resistance infections diagnosed in 2019, up from 61,946 in 2018. E. coli remains the most common bloodstream infection, rising 14% in 2015 to 77.5 in 2019, which is a significant concern. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 19, 2020 Category: Consumer Health News Source Type: news
New antibiotic-resistant infections rise
Antimicrobial resistance remains a serious threat to the health of people in England, with 178 AMR infections diagnosed each day, according to a PHE report. (Source: NHS Networks)
Source: NHS Networks - November 19, 2020 Category: UK Health Source Type: news
Silent Pandemic: Overuse renders antimicrobials less effective – UN agriculture agency
People, plants and animals around the world are dying from untreatable infections – even with the best medicines available – due to a rise in antimicrobial resistance, the UN food agriculture agency said on Wednesday, kicking off World Antimicrobial Awareness Week. (Source: UN News Centre - Health, Poverty, Food Security)
Source: UN News Centre - Health, Poverty, Food Security - November 18, 2020 Category: International Medicine & Public Health Source Type: news
Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?
On initial presentation, differentiation between earlystage coronavirus disease 2019 COVID-19) and classical bacterial community-acquired pneumonia can be challenging. Furthermore, COVID-19 patients may develop a hyperinflammatory phase later in their disease process, which is particularly difficult to distinguish from a secondary bacterial infection. As a consequence, 72% of COVID-19 patients receive empirical antibiotic therapy during hospital stay. Antibiotic overuse undoubtedly leads to an exacerbation of another —slowly progressive—pandemic: antimicrobial resistance. Procalcitonin (PCT) has proven useful in the ea...
Source: Current Awareness Service for Health (CASH) - November 18, 2020 Category: Consumer Health News Source Type: news
Nigeria: International and African Organizations Join Together to Fight Antimicrobial Drug Resistance
[Nigeria Health Watch] With antimicrobial resistance (AMR) threatening development and health in Africa, six international and continental organizations are launching the first partnership of its kind to combat this public health crisis on the continent. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 18, 2020 Category: African Health Source Type: news
World Antibiotic Awareness Week: 18 – 24 November 2020
World Antibiotic Awareness Week aims to avoid the further emergence and spread of antibiotic resistance by improving awareness and understanding of antimicrobial resistance through effective communication, education and training. (Source: NHS Networks)
Source: NHS Networks - November 17, 2020 Category: UK Health Source Type: news
