The LC/ESI-MSMS Profiles and Biological Potentials of Vitex agnus castus Extracts.
Authors: Ağalar HG, Çiftçi GA, Yιldιrιm SU, Göger F, Kιrιmer N
Abstract
The chemical profile, cytotoxic and apoptotic effect, and antioxidant activity were determined of ethanolic extracts of Vitex agnus-castus L. (chaste tree). Ripened fruits and fruitless aerial parts were extracted with ethanol, and the chemical characterization of the extracts was determined by LC/ESI-MS-MS. Twelve compounds were tentatively identified in the extracts. The dose-dependent cytotoxic effects of the extracts were tested on C6, A549 and MCF-7 cells by using MT7 assay; inhibition of DNA synthesis, and apoptotic and ...
Source: Natural Product Communications - January 2, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research
Optimizing a recombinant estrogen receptor binding assay for analysis of herbal extracts
Publication date: Available online 10 December 2018Source: Journal of Herbal MedicineAuthor(s): Sandra L. Gray, Brett R. LackeyAbstractPhytoestrogens may directly or indirectly affect the function of estrogen receptors. A method using human recombinant estrogen receptors alpha and beta (ERα and ERβ) was adapted for pure isoflavone compounds: glycitein, glycitin, biochanin A and formononetin; and extracts from chaste tree, Queen-Anne’s lace, Cyperus rhizome, dong quai, flaxseed, black cohosh, Siberian ginseng, saw palmetto, hops, licorice, red clover and alfalfa. Estrogen binding equivalents (EBE) for extracts binding w...
Source: Journal of Herbal Medicine - December 11, 2018 Category: Complementary Medicine Source Type: research
Efficacy of a Herbal Formulation Based on Foeniculum Vulgare in Oligo/Amenorrhea: A Randomized Clinical Trial.
CONCLUSION: Fomentex herbal tea is a safe, well-tolerated, and effective choice in inducing bleeding and maintaining regular bleeding in women with oligo/amenorrhea.
PMID: 30370852 [PubMed - as supplied by publisher] (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 29, 2018 Category: Drugs & Pharmacology Authors: Falahat F, Ayatiafin S, Jarahi L, Mokaberinejad R, Rakhshandeh H, Feyzabadi Z, Tavakkoli M Tags: Curr Drug Discov Technol Source Type: research
Vitex negundo and its medicinal value.
Abstract
Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer...
Source: Molecular Biology Reports - October 11, 2018 Category: Molecular Biology Authors: Gill BS, Mehra R, Navgeet, Kumar S Tags: Mol Biol Rep Source Type: research
Effects of a combination of Nigella sativa and Vitex agnus-castus with citalopram on healthy menopausal women with hot flashes: results from a subpopulation analysis
. (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - August 21, 2018 Category: Endocrinology Authors: Maryam Molaie Behrad Darvishi Zahra Jafari Azar Mahboobeh Shirazi Gholamreza Amin Shima Afshar Source Type: research
Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
ConclusionThe suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties
Publication date: May 2018Source: Journal of Integrative Medicine, Volume 16, Issue 3Author(s): Eric Wei Chiang Chan, Siu Kuin Wong, Hung Tuck ChanAbstractThis short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of V. negundo. Studies have reported the antiprolifera...
Source: Journal of Integrative Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research
Effects of Vitex agnus-castus extract on the secretory function of pituitary-gonadal axis and pregnancy rate in patients with premature ovarian aging (POA)
ConclusionVAC extract as a fertility-promoting plant appears to be a safe and effective herb for medicinal applications in women with POA when used within the established dosage guidelines. (Source: Journal of Herbal Medicine)
Source: Journal of Herbal Medicine - July 10, 2018 Category: Complementary Medicine Source Type: research
Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
ConclusionThe suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - July 6, 2018 Category: Drugs & Pharmacology Source Type: research
Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties
Publication date: May 2018Source: Journal of Integrative Medicine, Volume 16, Issue 3Author(s): Eric Wei Chiang Chan, Siu Kuin Wong, Hung Tuck ChanAbstractThis short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of V. negundo. Studies have reported the antiprolifera...
Source: Journal of Integrative Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research
Effects of Vitex agnus-castus extract on the secretory function of pituitary-gonadal axis and pregnancy rate in patients with premature ovarian aging (POA)
ConclusionVAC extract as a fertility-promoting plant appears to be a safe and effective herb for medicinal applications in women with POA when used within the established dosage guidelines. (Source: Journal of Herbal Medicine)
Source: Journal of Herbal Medicine - July 5, 2018 Category: Complementary Medicine Source Type: research
Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors
Conclusion The suggested strategy provides a reliable means of prospecting in-silico screening of natural products databases in the search for new dug leads as aromatase inhibitors. The hits so obtained can then be subjected to further phytochemical studies, to isolate and identify suitable compounds for further in-vitro testing. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - June 20, 2018 Category: Drugs & Pharmacology Source Type: research
Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine.
Conclusion. Traditional Persian medicine has proposed many different medicinal plants for treatment of oligomenorrhea and amenorrhea. Although just few plants have been proven to be effective for treatment of menstrual irregularities, the results and the classification in present study can be used as an outline for future studies and treatment.
PMID: 29744355 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - May 11, 2018 Category: Research Authors: Moini Jazani A, Hamdi K, Tansaz M, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nasimi Doost Azgomi R Tags: Biomed Res Int Source Type: research
Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties
Publication date: Available online 6 March 2018 Source:Journal of Integrative Medicine Author(s): Eric Wei Chiang Chan, Siu Kuin Wong, Hung Tuck Chan This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leaves of V. trifolia; aerial parts and seeds of V. agnus-castus and leaves of V. negundo. Studies have reported the antiprolifera...
Source: Journal of Integrative Medicine - March 7, 2018 Category: Complementary Medicine Source Type: research
