UCalgary researchers discover critical differences in the clots that cause a stroke
(University of Calgary) There are two main treatments for stroke caused by a clot in a blood vessel in the brain. University of Calgary scientists with the Hotchkiss Brain Institute at the Cumming School of Medicine have discovered that clots have different compositions and depending on where they are located in the brain, administering the clot-busting drug, Alteplase (also known as tPA), can be almost as effective as thrombectomy given sufficient time. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 11, 2018 Category: International Medicine & Public Health Source Type: news

May 18, 2018 This Week in Cardiology May 18, 2018 This Week in Cardiology
Device-related thrombosis with Watchman left atrial appendage closure, debulking atrial fibrillation after ablation, rivaroxaban for stroke prevention, alteplase, and Lp(a) are discussed this week.theheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 18, 2018 Category: Consumer Health News Tags: Cardiology Commentary Source Type: news

Tenecteplase: Thrombolytic of Choice in Stroke? Tenecteplase: Thrombolytic of Choice in Stroke?
The EXTEND-IA TNK trial suggesting better outcomes with tenecteplase than alteplase in the treatment of acute ischemic stroke has now been published in the New England Journal of Medicine.Medscape Medical News (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - April 26, 2018 Category: Intensive Care Tags: Neurology & Neurosurgery News Source Type: news

Tenecteplase Appears Superior to Alteplase After Ischemic Stroke
THURSDAY, April 26, 2018 -- For patients with ischemic stroke, treatment with tenecteplase within 4.5 hours of symptom onset and before thrombectomy is associated with better outcomes than treatment with alteplase during the same timeframe,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 26, 2018 Category: Pharmaceuticals Source Type: news

TNKase (Tenecteplase): A Better Clot-Buster Drug for Strokes?
THURSDAY, April 26, 2018 -- After a stroke, many patients are given the clot-busting intravenous drug alteplase, but another drug may be more effective, Australian researchers report. Among more than 200 stroke victims, TNKase (tenecteplase) was... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 26, 2018 Category: General Medicine Source Type: news

A Better Clot-Buster Drug for Strokes?
THURSDAY, April 26, 2018 -- After a stroke, many patients are given the clot-busting intravenous drug alteplase, but another drug may be more effective, Australian researchers report. Among more than 200 stroke victims, TNKase (tenecteplase) was... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 26, 2018 Category: General Medicine Source Type: news

Cathflo Activase (Alteplase Powder for Reconstitution for Use in Central Venous Access Devices) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 19, 2018 Category: Drugs & Pharmacology Source Type: news

Tenecteplase Superior to Alteplase for Stroke Thrombolysis Tenecteplase Superior to Alteplase for Stroke Thrombolysis
A noninferiority study shows the successful reperfusion rate was doubled in patients scheduled for thrombectomy who received tenecteplase compared with the current standard, alteplase.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 26, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Tenecteplase Superior to Alteplase for Stroke Lysis
(MedPage Today) -- But likelihood of gaining an official stroke indication appears remote (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 25, 2018 Category: Cardiology Source Type: news

Ischemic stroke patients not receiving life-saving treatment, study finds
(Georgia State University) Ischemic stroke patients who do not receive intravelous (IV) alteplase, a clot-dissolving medication, are significantly less likely to survive, according to researchers at Georgia State University. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 12, 2017 Category: International Medicine & Public Health Source Type: news

Recalled in US: Three Lots of Alteplase (Activase), Vial Leakage Hazard Recalled in US: Three Lots of Alteplase (Activase), Vial Leakage Hazard
Genentech says the thrombolytic agent in 100 mg vials was copackaged with sterile water for injection; the water vials may be"cracked or chipped" and no longer sterile.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 7, 2017 Category: Consumer Health News Tags: Cardiology News Alert Source Type: news

Genentech Issues Voluntary Nationwide Recall of Three Lots of Activase & reg; (Alteplase)-100 mg Due to Lack of Sterility Assurance of the Sterile Water for Injection
Genentech, a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY), is voluntarily recalling three lots of Activase ® (alteplase) 100mg vials, that were co-packaged with Sterile Water for Injection, to the hospital level. The vials of Sterile Water for Injection, manufactured by Hospira Inc., a Pfizer company, and packaged with Activase 100 mg, may be cracked or chipped at the neck of the vial and leaking. (Source: Food and Drug Administration)
Source: Food and Drug Administration - September 7, 2017 Category: Food Science Source Type: news

Tenecteplase Not Better or Safer in Ischemic Stroke
(MedPage Today) -- First head-to-head trial shows no advantage against alteplase (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - August 3, 2017 Category: American Health Source Type: news

Cathflo Activase (Alteplase Powder for Reconstitution for Use in Central Venous Access Devices) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 12, 2017 Category: Drugs & Pharmacology Source Type: news

Memphis Mobile Stroke Unit Saves Lives
A year after a mobile stroke unit hit the streets of Memphis, officials say it is saving lives by cutting the time it takes to treat stroke patients. The University of Tennessee Health Science Center began using the 14-ton ambulance last year as part of a three-year controlled study. The unit has a CT scanner that can X-ray images of the brain, and is equipped to provide early fluids to stroke patients and dye blood vessels to determine the type of stroke the patient has had. "The emergency room on average takes 40 to 50 minutes to do the things we do in 13 to 14 minutes," said Dr.Andrei Alexandrov, UTHSC neurolo...
Source: JEMS: Journal of Emergency Medical Services News - June 10, 2017 Category: Emergency Medicine Authors: Olivia Peterkin, The Commercial Appeal Tags: News Mobile Integrated Healthcare Source Type: news