UCalgary researchers discover critical differences in the clots that cause a stroke

(University of Calgary) There are two main treatments for stroke caused by a clot in a blood vessel in the brain. University of Calgary scientists with the Hotchkiss Brain Institute at the Cumming School of Medicine have discovered that clots have different compositions and depending on where they are located in the brain, administering the clot-busting drug, Alteplase (also known as tPA), can be almost as effective as thrombectomy given sufficient time.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Research on changes in cognitive function, β-amyloid peptide and neurotrophic factor in stroke patients. Eur Rev Med Pharmacol Sci. 2018 Oct;22(19):6448-6455 Authors: Chen HG, Wang M, Jiao AH, Tang GT, Zhu W, Zou P, Li T, Cui GQ, Gong PY Abstract OBJECTIVE: To investigate the changes as well as the related mechanism in cognitive function and levels of serum β-amyloid peptide (Aβ) and brain-derived neurotrophic factor (BDNF) in stroke patients. PATIENTS AND METHODS: A total of 30 patients with acute stroke treated in our hospital from June 2015 to September 2016 were selected as strok...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This study highlights the physiological stress temperature places on locomotor musculature and its consequences on whole organism locomotion. Cunner and tautog experience temperatures ranging from 0 to 25 °C and enter dormancy at ~10 °C. We aimed to address the question: how do winter temperatures affect steady swimming and muscle contraction kinetics in cunner? Fishes were collected and housed at 5, 10, 15, or 20 °C. Gait transition speed and fin beat frequency were measured at each acclimation temperature. Twitch and tetanus kinetics were recorded from the aerobic locomotor muscle, which is responsible ...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - Category: Biochemistry Source Type: research
ConclusionLack of drug efficacy, inappropriate drug adherence and patient knowledge were the major TRPs identified via delivering the MMR service to post-stroke patients. The identified TRPs highlights the importance of the MMR service, and supports planning future strategies aimed at decreasing the incidence of strokes.
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 October 2018Source: American Heart JournalAuthor(s): William J Davison, Phyo Kyaw Myint, Allan B Clark, John F PotterAbstractBackgroundGuidelines recommend ambulatory or home blood pressure monitoring to improve hypertension diagnosis and monitoring. Both these methods are ascribed the same threshold values, but whether they produce similar results has not been established in certain patient groups.MethodsAdults with mild/moderate stroke or transient ischaemic attack (N=80) completed two sets of ambulatory and home blood pressure monitoring. Systolic and diastolic blood pressure values...
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 19 October 2018Source: Neurochemistry InternationalAuthor(s): Seiichiro Sakai, Takashi ShichitaAbstractStroke causes neuronal cell death and destruction of neuronal circuits in the brain and spinal cord. Injury to the brain tissue induces sterile inflammation triggered by the extracellular release of endogenous molecules, but cerebral inflammation after stroke is gradually resolved within several days. In this pro-resolving process, inflammatory cells adopt a pro-resolving or repairing phenotype in the injured brain, activating endogenous repairing programs. Although the mechanisms involv...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Authors: Frich JC Abstract Henrik Ibsen (1828-1906) is a Norwegian playwright and poet who is known as the father of modern drama. Ibsen was in good health when he announced at his 70th birthday celebration that he intended to continue writing. His last play, When We Dead Awaken, was published in 1899. Why did Ibsen's dramatic writing come to an end? This chapter presents a medical account of Ibsen's health condition during the last 6 years of his life. It is based on a review of a document written by one of his doctors, Edvard Bull (1845-1925), letters, biographic information, and Ibsen's death certificate. The hi...
Source: Frontiers of Neurology and Neuroscience - Category: Neuroscience Tags: Front Neurol Neurosci Source Type: research
CONCLUSIONS: ASD in ExL-A causes a worsening of DLA and cognition similar to that observed in ExL-A with concomitant stroke indicating the need, in ageing patients, of differential diagnosis in order to achieve the best possible treatment. PMID: 30338749 [PubMed - as supplied by publisher]
Source: Current Aging Science - Category: Geriatrics Tags: Curr Aging Sci Source Type: research
Publication date: December 2018Source: Molecular Genetics and Metabolism Reports, Volume 17Author(s): Josef Finsterer
Source: Molecular Genetics and Metabolism Reports - Category: Genetics & Stem Cells Source Type: research
CONCLUSION: The variables used in the study showed applicability in assessing kinematic parameters in both the early and chronic period after stroke. PMID: 30338767 [PubMed - as supplied by publisher]
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
Publication date: Available online 19 October 2018Source: NeuroImage: ClinicalAuthor(s): Melissa Thye, Daniel MirmanAbstractDespite the widespread use of lesion-symptom mapping (LSM) techniques to study associations between location of brain damage and language deficits, the prediction of language deficits from lesion location remains a substantial challenge. The present study examined several factors which may impact lesion-symptom prediction by (1) testing the relative predictive advantage of general language deficit scores compared to composite scores that capture specific deficit types (2) isolating the relative contri...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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