Tenecteplase Appears Superior to Alteplase After Ischemic Stroke

THURSDAY, April 26, 2018 -- For patients with ischemic stroke, treatment with tenecteplase within 4.5 hours of symptom onset and before thrombectomy is associated with better outcomes than treatment with alteplase during the same timeframe,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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ConclusionsThese results demonstrate the practical utility of HSI for the real-time detection of cerebral ischemia in rats. By providing rapid assessment of brain tissue perfusion, HSI may help doctors recognize ischemic regions quickly and precisely during surgery as well as have great utility in the experimental process.
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
ConclusionSeizures did not predict in-hospital mortality in critically ill patients. Larger prospective studies are needed to confirm our current findings.
Source: Seizure - Category: Neurology Source Type: research
In this study, we synthesized a membrane-permeable peptide (Tat-CDK5-CTM) that specifically disrupts the binding of CDK5 and NR2B and then leads to the degradation of CDK5 by a lysosome-mediated pathway. We found that the administration of Tat-CDK5-CTM not only retards calcium overload and neuronal death in oxygen and glucose deprivation (OGD)-treated neurons but also reduced the infarction area and neuronal loss and improved the neurological functions in MCAO (middle cerebral artery occlusion) mice. The peptide-directed lysosomal degradation of CDK5 is a promising therapeutic intervention for stroke. Link:...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Intraplaque haemorrhage (IPH) has been independently associated with a higher risk of future ipsilateral stroke in patients with carotid artery stenosis. Evaluation of plaque characteristics may contribute to risk assessment of recurrent (silent) cerebrovascular events in order to prioritise patients for timing of treatment. It is unknown if patients showing histologically apparent IPH also have increased risk of silent ischaemic brain lesions in the waiting period between index event and revascularisation.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Background and aims: Atrial fibrillation (AF) is a major cause of ischemic stroke; however, detailed clinical data and prognostic factors for stroke patients with AF are lacking in Korea. We aimed to investigate clinical information and factors associated with functional outcomes of stroke patients with AF from the Korean nationwide ATrial fibrillaTion EvaluatioN regisTry in Ischemic strOke patieNts (K-ATTENTION) database.Methods: From January 2013 to December 2015, consecutive clinical information from acute stroke patients with AF or history of AF was collected from 11 centers in Korea. Collected data included demographi...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respectively. Among others, mechanisms include the regulation of neuronal plasticity processes, stimulation of angiogenesis and neurogenesis as well modulating the dynamics of cytoskeletal elements and intracellular transport processes. These mechanisms overlap with those that have been identified to enhance recover...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsCombining Gini coefficient and GIS network analysis in accessibility can be useful in quantifying and monitoring variation by region. We propose this combination as a new method for helping the government to make evidence-based healthcare planning.
Source: Health Policy and Technology - Category: Health Management Source Type: research
Authors: G─ůsiorek P, Sakowicz A, Banach M, von Haehling S, Bielecka-Dabrowa A Abstract Purpose: The study is aimed at identifying echocardiographic and circulating biomarkers as well as hemodynamic indices of embolic stroke of undetermined etiology (ESUS) in patients aged
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
THURSDAY, Oct. 17, 2019 -- For young and middle-aged veterans, posttraumatic stress disorder (PTSD) is associated with an increased risk for early incident transient ischemic attack (TIA) and ischemic stroke, according to a study published online...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
No abstract available
Source: Neurology Today - Category: Neurology Tags: For Your Patients Source Type: research
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