The effect of nano silver fluoride, self-assembling peptide and sodium fluoride varnish on salivary cariogenic bacteria: a randomized controlled clinical trial
ConclusionIn general, the antimicrobial effect of P11-4 and NSF on salivaryS. mutans andLactobacilli was not significantly different from NaF varnish. P11-4 induced greater reduction more quickly than the two other agents and NSF antibacterial effect was lost after one month.Clinical relevanceNSF varnish and P11-4 have antimicrobial activity that does not significantly differ from NaF by 3 months. P11-4 has the greatest antibacterial effect after one month with sustained effect till 3 months. The antibacterial effect of NSF lasts for one month. NaF remains effective till 3 months.Trial RegistrationThis trial was prospectiv...
Source: Clinical Oral Investigations - February 23, 2024 Category: Dentistry Source Type: research

Fluoride promotes the secretion of inflammatory factors in microglia through NLRP3/Caspase-1/GSDMD pathway
In conclusion, our results suggested that NLRP3/Caspase-1/GSDMD-mediated classical pyroptosis pathway was involved in fluoride-induced BV2 microglia damage.PMID:38367109 | DOI:10.1007/s11356-024-32443-6 (Source: Cell Research)
Source: Cell Research - February 17, 2024 Category: Cytology Authors: Qiuyi Zhang Tao Li Ruili Shi Ruifang Qi Xiaoqiong Hao Baohui Ma Source Type: research

Fluoride promotes the secretion of inflammatory factors in microglia through NLRP3/Caspase-1/GSDMD pathway
In conclusion, our results suggested that NLRP3/Caspase-1/GSDMD-mediated classical pyroptosis pathway was involved in fluoride-induced BV2 microglia damage.PMID:38367109 | DOI:10.1007/s11356-024-32443-6 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - February 17, 2024 Category: Environmental Health Authors: Qiuyi Zhang Tao Li Ruili Shi Ruifang Qi Xiaoqiong Hao Baohui Ma Source Type: research

Interactions and effects of a stannous-containing sodium fluoride dentifrice on oral pathogens and the oral microbiome
Numerous studies have investigated the effects of stannous ions on specific microbes and their efficacy in reducing dental plaque. Nonetheless, our understanding of their impact on the oral microbiome is still a subject of ongoing exploration. Therefore, this study sought to evaluate the effects of a stannous-containing sodium fluoride dentifrice in comparison to a zinc-containing sodium fluoride dentifrice and a control group on intact, healthy oral biofilms. Utilizing the novel 2bRAD-M approach for species-resolved metagenomics, and FISH/CLSM with probes targeting periodontal and caries associated species alongside Sn2+ ...
Source: Frontiers in Microbiology - February 15, 2024 Category: Microbiology Source Type: research

Quantification of Skeletal Muscle Perfusion in Peripheral Artery Disease Using < sup > 18 < /sup > F-Sodium Fluoride Positron Emission Tomography Imaging
CONCLUSIONS: 18F-NaF PET imaging quantifies perfusion deficits that correspond to clinical stages of PAD and represents a novel perfusion imaging strategy that could be partnered with atherosclerosis-targeted 18F-NaF PET imaging using a single radioisotope injection.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT03622359.PMID:38353265 | DOI:10.1161/JAHA.123.031823 (Source: Atherosclerosis)
Source: Atherosclerosis - February 14, 2024 Category: Cardiology Authors: Ting-Heng Chou Mahboubeh Nabavinia Nguyen K Tram Eleanor T Rimmerman Surina Patel Kumudha Narayana Musini Susan Natalie Eisert Tatiana Wolfe Molly K Wynveen Yuichi Matsuzaki Takahiro Kitsuka Ryuma Iwaki Sarah A Janse Adam J Bobbey Christopher K Breuer Lau Source Type: research

Efficacy of an experimental toothpaste containing sodium bicarbonate, sodium hyaluronate and sodium fluoride on gingivitis
Gingivitis is driven by plaque accumulation and, if left untreated, can progress to irreversible periodontitis. For many, the mechanical action of toothbrushing does not achieve adequate plaque control. The ai... (Source: BMC Oral Health)
Source: BMC Oral Health - February 9, 2024 Category: Dentistry Authors: Alyson Axe, Nisha Patel, Jimmy Qaqish, Martin R. Ling, Mako Araga, Charlie Parkinson and Chaju Ram Goyal Tags: Research Source Type: research

Fermented Rooibos tea (Aspalathus linearis) Ameliorates Sodium Fluoride-Induced Cardiorenal Toxicity, Oxidative Stress, and Inflammation via Modulation of NF- κB/IκB/IκKB Signaling Pathway in Wistar Rats
This study evaluated the potential protective effect of fermented rooibos tea (RTE) on sodium fluoride (NaF)-induced cardiorenal toxicity in rats. Male Wistar rats (n = 56) were randomly allocated into one of seven equal groups: control, NaF (100 mg/kg orally), NaF + RTE (2%, w/v), NaF + RTE (4%, w/v), NaF + lisinopril (10 mg/kg orally), 2% RTE, and 4% RTE. The experiment lasted for 14 days and RTE was administered to the rats as their sole source of drinking fluid. NaF induced cardiorenal toxicity indicated by elevated level of urea, creatinine, LDH, creatinine kinase-MB, and cardiac troponin I in the serum, accompanied b...
Source: Cardiovascular Toxicology - February 5, 2024 Category: Cardiology Authors: Olawale Razaq Ajuwon Toyosi Abiodun Adeleke Basiru Olaitan Ajiboye Akeem Olalekan Lawal Ibukun Folorunso Bartholomew Brai Fisayo Abraham Bamisaye John Adeolu Falode Ikenna Maximillian Odoh Kabirat Iyabode Adegbite Oluwasayo Bosede Adegoke Source Type: research

Achieving High Initial Coulombic Efficiency and Capacity in a Surface Chemical Grafting Layer of Plateau-type Sodium Titanate
ChemSusChem. 2024 Jan 24:e202301598. doi: 10.1002/cssc.202301598. Online ahead of print.ABSTRACTThe plateau-type sodium titanate with suitable sodiation potential is a promising anode candidate for high safe and high energy density of sodium-ion batteries (SIBs). However, the poor initial Coulombic efficiency (ICE) and cyclic instability of sodium titanate are attributed to the unstable interfacial structure along with the decomposition of electrolytes, resulting in the continuous formation of solid electrolyte interface (SEI) film. To address this issue, a chemical grafting method is developed to fabricate a highly stable...
Source: ChemSusChem - January 24, 2024 Category: Chemistry Authors: Yanlei Zhang Linwei Li Feng Wang Huicai Wang Zhenming Jiang Zhimin Lin Zhengshuai Bai Yinzhu Jiang Yanyan Zhang Binmeng Chen Yuxin Tang Source Type: research

Exercise Alleviates Fluoride-Induced Learning and Memory Impairment in Mice: Role of miR-206-3p and PREG
Biol Trace Elem Res. 2024 Jan 20. doi: 10.1007/s12011-024-04068-w. Online ahead of print.ABSTRACTFluorosis decreases the learning and memory ability in humans and animals, while exercise can reduce the risk of cognitive decline. However, the effect of exercise on learning and memory in fluoride-exposed mice is unclear. For this purpose, in this study, mice were randomly allotted into four groups (16 mice per group, half male and half female): control group (group C), fluoride group (group F, 100 mg/L sodium fluoride (NaF)), exercise group (group E, treadmill exercise), and E plus F group (group EF, treadmill exercise, and ...
Source: Biological Trace Element Research - January 20, 2024 Category: Biology Authors: Lei Chai Qiqi Cao Ke Liu Run Zhu Hao Li Yanghuan Yu Jixiang Wang Ruiyan Niu Ding Zhang Bo Yang Mohammad Mehdi Ommati Zilong Sun Source Type: research

Sodium fluoride preserves blood metabolite integrity for biomarker discovery in large-scale, multi-site metabolomics investigations
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Wenzheng Xiong, Daniel C Anthony, Suzie Anthony, Thi Bao Tien Ho, Edouard Louis, Jack Satsangi, Daniel E Radford-Smith Background: Metabolite profiling of blood by nuclear magnetic resonance (NMR) is invaluable to clinical biomarker discovery. To ensure robustness, biomarkers require validation in large cohorts and across multiple centres. However,... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - January 12, 2024 Category: Chemistry Authors: Wenzheng Xiong Source Type: research

Proof-of-principle study using < em > Saccharomyces cerevisiae < /em > for universal screening test for cancer through ultrasound-based size distinction of circulating tumor cell clusters
J Biosci. 2024;49:14.ABSTRACTScreening strategies for cancer, the second largest cause of deaths, exist, but are invasive, cumbersome, and expensive. Many cancers lack viable screening modalities all together. Circulating tumor cell clusters (CTCCs) are seen during early stages of cancer and are larger than normal blood cells. Discrimination of such differential sizes by real-time ultrasound scanning of a blood vessel offers an attractive universal screening tool for cancer. Yeast colonies were grown to different sizes mimicking CTCCs and normal blood cells, using sugar and starch to incubate and sodium fluoride to arrest ...
Source: Journal of Biosciences - January 11, 2024 Category: Biomedical Science Authors: Saksham Rajan Saksena Sandeep Kumar Rajan Source Type: research

Clinical Positron Emission Tomography/Computed Tomography
Although positron emission tomography/computed tomography (PET/CT) underwent rapid growth during the last quarter-century, becoming a new standard-of-care for imaging most cancer types, CT and bone scan remained the gold standard for patients with prostate cancer. This occurred as 2-fluorine-18-fluoro-2-deoxy-d-glucose was perceived to have a limited role owing to low sensitivity in many patients. A resurgence of interest occurred with the use of fluorine-18-sodium-fluoride PET/CT as a replacement for bone scintigraphy, and then choline, fluciclovine, and dihydrotestosterone (DHT) PET/CT as prostate “specific” radiotra...
Source: PET Clinics - January 9, 2024 Category: Radiology Authors: David C. Chen, Siyu Huang, James P. Buteau, Raghava Kashyap, Michael S. Hofman Source Type: research

Quarter-Century Transformation of Oncology: Positron Emission Tomography for Patients with Breast Cancer
This article will describe the advances during the last quarter century in PET for patients with breast cancer.PMID:38177052 | DOI:10.1016/j.cpet.2023.12.002 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 4, 2024 Category: Cancer & Oncology Authors: Gary A Ulaner Sofia Carrilho Vaz David Groheux Source Type: research

Quarter-Century Transformation of Oncology: Positron Emission Tomography for Patients with Breast Cancer
This article will describe the advances during the last quarter century in PET for patients with breast cancer.PMID:38177052 | DOI:10.1016/j.cpet.2023.12.002 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 4, 2024 Category: Cancer & Oncology Authors: Gary A Ulaner Sofia Carrilho Vaz David Groheux Source Type: research

Quarter-Century Transformation of Oncology: Positron Emission Tomography for Patients with Breast Cancer
This article will describe the advances during the last quarter century in PET for patients with breast cancer.PMID:38177052 | DOI:10.1016/j.cpet.2023.12.002 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - January 4, 2024 Category: Cancer & Oncology Authors: Gary A Ulaner Sofia Carrilho Vaz David Groheux Source Type: research