A new insight into fluoride induces cardiotoxicity in chickens: involving the regulation of PERK/IRE1/ATF6 pathway and heat shock proteins
This study investigated the effects of long-term exposure to sodium fluoride (0, 500, 1000, and 2000mg/kg) on the hearts of chickens were investigated. The results showed that an elevated exposure dose of sodium fluoride led to congested cardiac tissue and disrupted myofiber organisation. Sodium fluoride exposure activated the ERS pathways of PERK, IRE1, and ATF6, increasing HSP60 and HSP70 and decreasing HSP90. The NF-κB pathway and the activation of TNF-α and iNOS elicited an inflammatory response. BAX, cytc, and cleaved-caspase3 were increased, triggering apoptosis and leading to cardiac injury. The abnormal expressio...
Source: Toxicology - November 30, 2023 Category: Toxicology Authors: Lulu Hou Haiyan Dong Enyu Zhang Hongmin Lu Yue Zhang Hongjing Zhao Mingwei Xing Source Type: research
A new insight into fluoride induces cardiotoxicity in chickens: involving the regulation of PERK/IRE1/ATF6 pathway and heat shock proteins
This study investigated the effects of long-term exposure to sodium fluoride (0, 500, 1000, and 2000mg/kg) on the hearts of chickens were investigated. The results showed that an elevated exposure dose of sodium fluoride led to congested cardiac tissue and disrupted myofiber organisation. Sodium fluoride exposure activated the ERS pathways of PERK, IRE1, and ATF6, increasing HSP60 and HSP70 and decreasing HSP90. The NF-κB pathway and the activation of TNF-α and iNOS elicited an inflammatory response. BAX, cytc, and cleaved-caspase3 were increased, triggering apoptosis and leading to cardiac injury. The abnormal expressio...
Source: Toxicology - November 30, 2023 Category: Toxicology Authors: Lulu Hou Haiyan Dong Enyu Zhang Hongmin Lu Yue Zhang Hongjing Zhao Mingwei Xing Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
Efficacy of Different Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
Conclusions: Ultimately, with both fluoride therapies reducing hypersensitivity/pain significantly, treatment with 38% SDF+KI was clearly more effective in caries arrest than 5% NaF varnish after a 3-month period.PMID:38004091 | PMC:PMC10672976 | DOI:10.3390/medicina59112042 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - November 25, 2023 Category: Universities & Medical Training Authors: Mohamed Abudrya Christian H Splieth Mhd Said Mourad Ruth M Santamar ía Source Type: research
