Effectiveness of a treat-to-target strategy in patients with moderate to severely active rheumatoid arthritis treated with abatacept
To compare a treat-to-target (T2T) approach and routine care (RC) in adults with active to severely active rheumatoid arthritis (RA) initiating subcutaneous abatacept. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 28, 2023 Category: Rheumatology Authors: Louis Bessette, Boulos Haraoui, Emmanouil Rampakakis, Joanna Dembowy, Marc-Olivier Tr épanier and Janet Pope Tags: Research Source Type: research
Monogenic inborn errors of immunity in autoimmune disorders
In conclusion, 50% of children with AID have underlying PIRD.LRBA deficiency andSTAT1 GOF were the most common PIRD. Age at presentation, number of autoimmunity, routine immunological tests, and JMF criteria are not predictive of underlying PIRD. Early diagnosis with exome sequencing alters the prognosis and opens new therapeutic avenue. (Source: Immunologic Research)
Source: Immunologic Research - September 27, 2023 Category: Allergy & Immunology Source Type: research
Certolizumab pegol, abatacept, tocilizumab or active conventional treatment in early rheumatoid arthritis: 48-week clinical and radiographic results of the investigator-initiated randomised controlled NORD-STAR trial
Conclusions
Compared with active conventional therapy, clinical remission rates were superior for abatacept and certolizumab pegol, but not for tocilizumab. Radiographic progression was low and similar between treatments.
Trial registration number
NCT01491815. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - September 19, 2023 Category: Rheumatology Authors: Ostergaard, M., van Vollenhoven, R. F., Rudin, A., Hetland, M. L., Heiberg, M. S., Nordström, D. C., Nurmohamed, M. T., Gudbjornsson, B., Ornbjerg, L. M., Boyesen, P., Lend, K., Horslev-Petersen, K., Uhlig, T., Sokka, T., Grondal, G., Krabbe, S., Tags: Editor's choice, ARD, Rheumatoid arthritis Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Hepatic safety and efficacy of immunomodulatory drugs used in patients with autoimmune hepatitis
CONCLUSION: Among 25 AIH patients who were treated with immunomodulatory drugs for different reasons, the majority had a fovorable course, relapse was frequent in difficult-to-treat patients who received belimumab, and four with concomitant IBD had insufficient response.PMID:37716078 | DOI:10.1016/j.jaut.2023.103113 (Source: Journal of Autoimmunity)
Source: Journal of Autoimmunity - September 16, 2023 Category: Allergy & Immunology Authors: Benedetta Terziroli Beretta-Piccoli Gustav Buescher George Dalekos Kalliopi Zachou Anja Geerts Nasser Semmo Mirjam Kolev Eleonora De Martin Maciej K Janik Jo ão Madaleno Milica Lalosevic Stojkovic J érôme Dumortier Thomas Vanwolleghem Ida Schregel Silj Source Type: research
Abatacept in usual and in non-specific interstitial pneumonia associated with rheumatoid arthritis
CONCLUSION: ABA seems equally effective in stabilizing dyspnoea, lung function and radiological impairment in both UIP and NSIP patterns of RA-ILD. Early administration of ABA may prevent RA-ILD progression, regardless of the radiological pattern.PMID:37673775 | DOI:10.1016/j.ejim.2023.08.025 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - September 6, 2023 Category: Internal Medicine Authors: Bel én Atienza-Mateo Carlos Fern ández-Díaz Esther F Vicente-Rabaneda Rafael B Melero-Gonz ález Francisco Ortiz-Sanju án Ivette Casafont-Sol é Sebasti án C Rodríguez-García Iv án Ferraz-Amaro Santos Casta ñeda Ricardo Blanco Spanish Collaborati Source Type: research
Abatacept in usual and in non-specific interstitial pneumonia associated with rheumatoid arthritis
CONCLUSION: ABA seems equally effective in stabilizing dyspnoea, lung function and radiological impairment in both UIP and NSIP patterns of RA-ILD. Early administration of ABA may prevent RA-ILD progression, regardless of the radiological pattern.PMID:37673775 | DOI:10.1016/j.ejim.2023.08.025 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - September 6, 2023 Category: Internal Medicine Authors: Bel én Atienza-Mateo Carlos Fern ández-Díaz Esther F Vicente-Rabaneda Rafael B Melero-Gonz ález Francisco Ortiz-Sanju án Ivette Casafont-Sol é Sebasti án C Rodríguez-García Iv án Ferraz-Amaro Santos Casta ñeda Ricardo Blanco Spanish Collaborati Source Type: research
Biologics in steroid resistant nephrotic syndrome in childhood: review and new hypothesis-driven treatment
Nephrotic syndrome affects about 2–7 per 100,000 children yearly and accounts for less than 15% of end stage kidney disease. Steroids still represent the cornerstone of therapy achieving remission in 75–90% of the cases The remaining part result as steroid resistant nephrotic syndrome, characterized by the elevated risk of developing end stage kidney disease and frequently presenting disease recurrence in case of kidney transplant. The pathogenesis of nephrotic syndrome is still far to be elucidated, however, efficacy of immune treatments provided the basis to suggest the involvement of the immune system in the pathoge...
Source: Frontiers in Immunology - August 29, 2023 Category: Allergy & Immunology Source Type: research
Humoral and T-cell response to SARS-CoV-2 vaccination in patients with rheumatoid arthritis
CONCLUSION: In this RA cohort vaccinated with homologous and heterologous regimens against COVID-19, two out of ten patients did not develop IgG anti-SARS-CoV-2, 70% presented neutralizing activity and 65% specific T-cell response. The use of BBIBP-CorV was associated with deficient humoral and cellular response, while treatment with ABA and RTX resulted in an impaired IgG anti-SARS-CoV-2 formation and neutralizing activity. This article is protected by copyright. All rights reserved.PMID:37605835 | DOI:10.1002/acr.25221 (Source: Cell Research)
Source: Cell Research - August 22, 2023 Category: Cytology Authors: Carolina A Isnardi Margarita Landi Leonel Cruces Pablo Maid Claudia Calle Montoro Mar ía A Alfaro Brian M Rold án Andrea B G ómez Vara Pamela Giorgis Roberto A Ezquer Mar ía G Crespo Rocha Camila R Reyes G ómez Mar ía Á Correa Osvaldo L Cerda Marco Source Type: research
Abatacept for graft versus host disease prophylaxis in patients 60 years and older receiving mismatched unrelated donor transplantation for hematologic malignancies
Bone Marrow Transplantation, Published online: 14 August 2023; doi:10.1038/s41409-023-02043-yAbatacept for graft versus host disease prophylaxis in patients 60 years and older receiving mismatched unrelated donor transplantation for hematologic malignancies (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - August 14, 2023 Category: Hematology Authors: Sharmila Raghunandan Muna Qayed Ben K. Watkins Michael Graiser Lev Gorfinkel Adrianna Westbrook Scott Gillespie Brandi Bratrude Aleksandra Petrovic Yvonne Suessmuth John Horan Leslie S. Kean Amelia A. Langston Source Type: research
