The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
The NMR signature of maltose-based glycation in full-length proteins
We present here a detailed NMR analysis of the Amadori product formed between proteins and maltose. For better comparison, data collection was done under denaturing conditions using 7 M urea-d4 in D2O. The here presented correlation patterns serve as a signature and can be used to identify maltose-based glycation in any protein that can be denatured. In addition to the model protein BSA, which can be readily glycated, we present data of the biotherapeutic abatacept containing maltose in its formulation buffer. With this contribution, we demonstrate that NMR spectroscopy is an independent method for detecting maltose-based ...
Source: Journal of Bimolecular NMR - December 20, 2023 Category: Biomedical Science Authors: Pauline Defant Christof Regl Christian G Huber Mario Schubert Source Type: research
[ < sup > 18 < /sup > F]FDG PET/CT for therapeutic assessment of Abatacept in early-onset polymyalgia rheumatica
CONCLUSION: [18F] FDG PET/CT uptake did not decrease significantly after ABA compared to placebo in anatomical areas usually affected in PMR patients. These results are correlated with the clinical-biological therapeutic assessment.CLINICAL TRIAL REGISTRATION: The study was approved by the appropriate ethics committee (CPP Sud-Est II Ref CPP: 2018-33), and all patients gave their written informed consent before study enrollment. The protocol was registered on Clinicaltrials.gov (NCT03632187).PMID:38095675 | DOI:10.1007/s00259-023-06557-x (Source: Molecular Medicine)
Source: Molecular Medicine - December 14, 2023 Category: Molecular Biology Authors: Bastien Allard Val érie Devauchelle-Pensec Alain Saraux Emmanuel Nowak Alice Tison Sara Boukhlal Dewi Guellec Sandrine Jousse-Joulin Divi Cornec Thierry Marhadour Romain Le Pennec Pierre-Yves Sala ün Sol ène Querellou Source Type: research
Abatacept treatment for autoimmune hemolytic anemia occurring post hematopoietic stem cell transplantation
Bone Marrow Transplantation, Published online: 14 December 2023; doi:10.1038/s41409-023-02173-3Abatacept treatment for autoimmune hemolytic anemia occurring post hematopoietic stem cell transplantation (Source: Bone Marrow Transplantation)
Source: Bone Marrow Transplantation - December 14, 2023 Category: Hematology Authors: Maria Gabelli Antonio P érez-Martínez David Bueno S ánchez Giovanna Lucchini Louis-Philippe Grenier Felix Couture Emily Limerick Victoria Bernaud Maria Trabazo del Castillo Alexander Ngwube Source Type: research
[18F]FDG PET/CT for therapeutic assessment of Abatacept in early-onset polymyalgia rheumatica
Conclusion[18F] FDG PET/CT uptake did not decrease significantly after ABA compared to placebo in anatomical areas usually affected in PMR patients. These results are correlated with the clinical-biological therapeutic assessment.Clinical trial registrationThe study was approved by the appropriate ethics committee (CPP Sud-Est II Ref CPP: 2018 –33), and all patients gave their written informed consent before study enrollment.The protocol was registered on Clinicaltrials.gov (NCT03632187). (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - December 14, 2023 Category: Nuclear Medicine Source Type: research
