SGLT2 Inhibition Reduces Vascular Dysfunction in Aged Mice

We report that Empa-treated mice exhibited improved mesenteric endothelial function compared with control, in parallel with reduced mesenteric artery and aortic stiffness. Our findings demonstrate that Empa improves endothelial function and reduces arterial stiffness in a preclinical model of aging, making SGLT2 inhibition a potential therapeutic alternative to reduce the progression of cardiovascular disease in older individuals. Link: https://doi.org/10.1007/s11357-022-00563-x
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs