Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice

CONCLUSIONS: These results indicate that SERD treatment can decrease binge-like ethanol drinking in female mice and in theory could be a novel strategy to reduce binge drinking in women, with the caveat that effectiveness may depend on menstrual cycle phase. In addition, Esr1 transcript is increased by binge ethanol exposure in both sexes but in a brain region-specific manner.PMID:35581531 | DOI:10.1111/acer.14874

Source: Alcoholism, Clinical and Experimental Research - May 17, 2022 Category: Addiction Authors: Hu Chen Yunlong Lu Rui Xiong Carlo I Rosales Cassandre Coles Kana Hamada Nuria Asad Gregory R J Thatcher Amy W Lasek Source Type: research