Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice

CONCLUSIONS: These results indicate that SERD treatment can decrease binge-like ethanol drinking in female mice and in theory could be a novel strategy to reduce binge drinking in women, with the caveat that effectiveness may depend on menstrual cycle phase. In addition, Esr1 transcript is increased by binge ethanol exposure in both sexes but in a brain region-specific manner.PMID:35581531 | DOI:10.1111/acer.14874
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research