Perphenazine and prochlorperazine decrease glioblastoma U-87 MG cell migration and invasion: Analysis of the ABCB1 and ABCG2 transporters, E-cadherin, α-tubulin and integrins (α3, α5, and β1) levels
In conclusion, the decrease in migratory and invasive ability following treatment with phenothiazine derivatives due to the increase in ABCG2 and E-cadherin expression, and decrease in α-tubulin and integrins expression, may suggest that research on perphenazine and prochlorperazine in the treatment of glioblastoma is worth continuing.PMID:35527777 | PMC:PMC9073583 | DOI:10.3892/ol.2022.13302
Source: Oncology Letters - Category: Cancer & Oncology Authors: Micha ł Otręba Jerzy Stojko Agata Kaba ła-Dzik Anna Rzepecka-Stojko Source Type: research
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