Globally elevated excitation –inhibition ratio in children with autism spectrum disorder and below-average intelligence

ConclusionsThe atypically flattened spectral slope of aperiodic activity in children with ASD and below-average IQ suggests a shift of the global E –I balance toward hyper-excitation. The spectral slope can provide an accessible noninvasive biomarker of the E–I ratio for making objective judgments about treatment effectiveness in people with ASD and comorbid intellectual disability.
Source: Molecular Autism - Category: Molecular Biology Source Type: research