Clinical impact of kir2ds3 and kir2dl3 genes in neuroblastoma patients

Neuroblastoma is a common fatal tumor of childhood. Natural killer (NK) cells can exert direct cytotoxicity on tumor cells. The killer immunoglobulin-like receptor (KIR) family of NK cell receptors are involved in activation/inhibition of the NK cells. In the KIR gene cluster, six of them (3DS1, 2DS1 –5) encode receptors triggering activation and seven of them (3DL1–3, 2DL1–3, 2DL5) encode receptors triggering inhibition. We aimed to assess the distribution of genetic polymorphisms of KIRs on the clinical course of neuroblastoma and provide guidance on potential therapeutic options. Our st udy group included fifty neuroblastoma patients and one hundred healthy children as the control. Twenty-eight patients were boys and twenty-two were girls; median age was thirty-six months (range 3-113 mos). Fourteen patients had stage 1,2,3 or 4S disease, thirty-six patients had stage 4 disease. Al l patients had lower frequency of KIR2DS3 compared to the control group (P= 0.005). Evaluation of individual KIR genes/genotypes in patients with early stages (stage 1, 2, 3 and 4S) versus stage 4 disease revealed KIR2DS3 frequency was increased in early stages (P=0.023). Inhibitory KIR2DL3 increase in the patient group compared to control was statistically significant (P= 0.038). Furthermore, the frequency of KIR2DL3 was higher in stage 4 neuroblastoma patients compared to the patients with early stages (P=0.023). Our data demonstrates a role for KIR2DS3 and KIR2DL3 in development of neur...
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research