Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder

CONCLUSION: In our validation study the most important factors contributing to good performance were absence of children, Asian ethnicity, one-compartment models and inclusion of body weight and VPA dose in previously published models.PMID:35536685 | DOI:10.1080/17512433.2022.2075849

Source: Pharmacological Reviews - May 10, 2022 Category: Drugs & Pharmacology Authors: Yan-Nan Zang Wei Guo Fang Dong An-Ning Li Jose de Leon Can-Jun Ruan Source Type: research