Multiple Early-life Seizures Alters Neonatal Communicative Behavior in Fmr1 Knockout Mice

Fragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and a significant contributor to Autism Spectrum Disorder. Individuals with FXS are subject to developing numerous comorbidities, one of the most prevalent being seizures. In the present study, we investigated how seizures affected neonatal communicative behavior in the FXS mouse model. On postnatal day (PD) 7 through 11, we administered 3 flurothyl seizures per day to both Fmr1 knockout and wildtype C57BL/6J male mice. Ultrasonic vocalizations were recorded on PD12. Statistically significant alterations were found in both spectral and temporal measurements across seizure groups. We found that induction of seizures across PD7 –11 resulted in an increased fundamental frequency (pitch) of ultrasonic vocalizations produced (p
Source: Developmental Neuroscience - Category: Neuroscience Source Type: research