Polymorphisms of potential drug resistant molecular markers in Plasmodium vivax from China –Myanmar border during 2008‒2017

ConclusionsMutations related with resistance to antifolate drugs are prevalent in this area, while their frequencies decrease significantly with time, suggestive of increased susceptibility ofP. vivax parasite to antifolate drugs. Resistance to chloroquine (CQ) is possibly emerging. However, since the molecular mechanisms underneath CQ resistance is yet to be better understood, close supervision of clinical drug efficiency and continuous function investigation is urgently needed to alarm drug resistance.Graphical abstract
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research