Cardiac consequences of intermittent hypoxia: a matter of dose? A systematic review and meta-analysis in rodents

Conclusion
This meta-analysis demonstrated that severe IH systematically induces cardiac remodelling and contractile dysfunction in rodents, which might trigger or aggravate chronic heart failure. Interestingly, this meta-analysis showed that, depending on stimulus severity, IH exhibits both protective and aggravating effects on infarct size after experimental ischaemia–reperfusion procedures.

Source: European Respiratory Review - April 13, 2022 Category: Respiratory Medicine Authors: Belaidi, E., Khouri, C., Harki, O., Baillieul, S., Faury, G., Briancon-Marjollet, A., Pepin, J.-L., Arnaud, C. Tags: Lung biology and experimental studies Reviews Source Type: research