Omeprazole-clopidogrel interaction and neurovascular complications after flow-diverter device placement

Conclusion
Omeprazole was associated with a significant increase in the mean P2Y12 reactivity level among patients with intracranial aneurysms treated with flow-diverting devices who received clopidogrel. However, receipt of omeprazole was not associated with an increased risk of ischemic events or stent stenosis. For neuroendovascular patients who are treated with a flow diverter while receiving clopidogrel, alternative gastrointestinal medication regimens should be considered.

Source: Journal of NeuroInterventional Surgery - March 18, 2022 Category: Neurosurgery Authors: Catapano, J. S., Srinivasan, V. M., Wakim, A. A., Lundberg, J. N., Rutledge, C., Cole, T. S., Baranoski, J. F., Fredrickson, V. L., Rahmani, R., Albuquerque, F. C., Ducruet, A. F. Tags: Hemorrhagic stroke Source Type: research