Neurotoxicity of four frequently used nanoparticles: a systematic review to reveal the missing data

Arch Toxicol. 2022 Mar 12. doi: 10.1007/s00204-022-03233-1. Online ahead of print.ABSTRACTSystemic exposure to nanoparticles (NPs) adversely affects different organs, including the nervous system. We systematically extracted data from publication on PubMed and Embase database up to the year 2020, and analyzed in vitro and in vivo neurotoxicity of 4 of the most well studied NPs (silver NPs, carbon-based NPs, iron NPs and silica NPs). A relatively good correlation was observed between in vitro and in vivo effects, including genotoxicity, oxidative stress, apoptosis and pro-inflammatory effects. However, crucial knowledge gap exists in current understanding of the underlying mechanisms. Some of the critical knowledge gaps and research needs identified in relation to neurotoxicity of nanoparticles include (1) lack of physio-chemical characteristics of NPs used, (2) cellular/tissue uptake of NP, (3) NP translocation across the blood-brain barrier (BBB), (4) Effect of exposure routes.PMID:35278105 | DOI:10.1007/s00204-022-03233-1

Source: Archives of Toxicology - March 12, 2022 Category: Toxicology Authors: Jia-You Gong Matthew G Holt Peter H M Hoet Manosij Ghosh Source Type: research