EVITA Dengue: a cluster-randomized controlled trial to EValuate the efficacy of Wolbachia-InfecTed Aedes aegypti mosquitoes in reducing the incidence of Arboviral infection in Brazil

DiscussionDMID 17-0111 aims to determine the efficacy ofWolbachia-infected mosquito releases in reducing human infections by arboviruses transmitted byAedes aegypti and will complement the mounting evidence for this method from large-scale field releases and ongoing trials. The trial also represents a critical step towards robustness and rigor for how vector control methods are assessed, including the simultaneous measurement and correlation of entomologic and epidemiologic outcomes. Data from this trial will inform further the development of novel vector control methods.Trial registrationClinicalTrials.govNCT04514107. Registered on 17 August 2020Primary sponsor: National Institute of Health, National Institute of Allergy and Infectious Diseases
Source: Trials - Category: Research Source Type: clinical trials