The calcium sensor, rather than the route of calcium entry, defines cerebellar plasticity pathways [Biological Sciences]
Schonewille et al. (1) show that genetic deletion of GluN1 N-methyl-D-aspartate receptors (NMDARs) from cerebellar granule cells (GC-GluN1 ko), but not from Purkinje cells (PC-GluN1 ko), impairs long-term depression (LTD) at parallel fiber (PF) to PC synapses and vestibuloocular reflex (VOR) phase reversal. NMDARs are postsynaptically expressed at climbing fiber...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Claire Piochon, Carole Levenes, Heather K. Titley, Christian Hansel Tags: Letters, Neuroscience Source Type: research
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