The calcium sensor, rather than the route of calcium entry, defines cerebellar plasticity pathways [Biological Sciences]

Schonewille et al. (1) show that genetic deletion of GluN1 N-methyl-D-aspartate receptors (NMDARs) from cerebellar granule cells (GC-GluN1 ko), but not from Purkinje cells (PC-GluN1 ko), impairs long-term depression (LTD) at parallel fiber (PF) to PC synapses and vestibuloocular reflex (VOR) phase reversal. NMDARs are postsynaptically expressed at climbing fiber...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Letters, Neuroscience Source Type: research