Association of Coronary Plaque With Low-Density Lipoprotein Cholesterol Levels and Rates of Cardiovascular Disease Events Among Symptomatic Adults

CONCLUSIONS AND RELEVANCE: The findings of this cohort study suggest that in symptomatic patients with severely elevated LDL-C levels of at least 190 mg/dL who are universally considered to be at high risk by guidelines, absence of calcified and noncalcified plaque on coronary computed tomographic angiography was associated with low risk for ASCVD events. These results further suggest that atherosclerosis burden, including CAC, can be used to individualize treatment intensity in patients with severely elevated LDL-C levels.PMID:35147685 | DOI:10.1001/jamanetworkopen.2021.48139

Source: Atherosclerosis - February 11, 2022 Category: Cardiology Authors: Martin B ødtker Mortensen Miguel Ca ínzos-Achirica Flemming Hald Steffensen Hans Erik B øtker Jesper M øller Jensen Niels Peter R ønnow Sand Michael Maeng Jens Meldgaard Bruun Michael J Blaha Henrik Toft S ørensen Manan Pareek Khurram Nasir Bjarne L Source Type: research