A distinct role of STING in regulating glucose homeostasis through insulin sensitivity and insulin secretion [Cell Biology]

Insulin resistance and β-cell dysfunction are two main molecular bases yet to be further elucidated for type 2 diabetes (T2D). Accumulating evidence indicates that stimulator of interferon genes (STING) plays an important role in regulating insulin sensitivity. However, its function in β-cells remains unknown. Herein, using global STING knockout (STING−/−)...

Source: Proceedings of the National Academy of Sciences - February 10, 2022 Category: Science Authors: Jingting Qiao, Ziyin Zhang, Shuhui Ji, Tengli Liu, Xiaona Zhang, Yumeng Huang, Wenli Feng, Kunling Wang, Jianyu Wang, Shusen Wang, Zhuo-Xian Meng, Ming Liu Tags: Cell Biology Biological Sciences Source Type: research