Disrupted Cacna1c gene expression perturbs spontaneous Ca2+ activity causing abnormal brain development and increased anxiety [Neuroscience]

The L-type voltage-gated Ca2+ channel gene CACNA1C is a risk gene for various psychiatric conditions, including schizophrenia and bipolar disorder. However, the cellular mechanism by which CACNA1C contributes to psychiatric disorders has not been elucidated. Here, we report that the embryonic deletion of Cacna1c in neurons destined for the cerebral...

Source: Proceedings of the National Academy of Sciences - February 8, 2022 Category: Science Authors: Erik Smedler, Lauri Louhivuori, Roman A. Romanov, Debora Masini, Ivar Dehnisch Ellstrom, Chungliang Wang, Martino Caramia, Zoe West, Songbai Zhang, Paola Rebellato, Seth Malmersȷo, Irene Brusini, Shigeaki Kanatani, Gilberto Fisone, Tibor Harkany, P Tags: Neuroscience Biological Sciences Source Type: research