Alpha-1-Antitrypsin Experience for Steroid-Resistant Acute Graft-Versus-Host Disease

This study aims to evaluate the effectiveness and safety of alpha-1-antitrypsin (AAT). In the study, the results of five SR-aGVHD patients received AAT evaluated. Complete response was seen 2 of four patients with gastrointestinal (GI) aGVHD, partial response in one GI and one liver aGVHD. The overall response rate was 80%. AAT is an effective and safe treatment option in SR-aGVHD.
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research