Hypertrophic Cardiomyopathy: New Concepts and Therapies

Annu Rev Med. 2022 Jan 27;73:363-375. doi: 10.1146/annurev-med-042220-021539.ABSTRACTHypertrophic cardiomyopathy (HCM), a relatively common, globally distributed, and often inherited myocardial disorder, transformed over the last several years into a treatable condition with the emergence of effective management options that alter natural history at all ages. Now available are a matured risk stratification algorithm selecting patients for prophylactic implantable defibrillators that prevent arrhythmic sudden death; low-risk, high-benefit surgical myectomy to reverse progressive heart failure symptoms due to left ventricular outflow obstruction; anticoagulation prophylaxis to prevent atrial fibrillation-mediated embolic stroke; and heart transplant for refractory end-stage disease in the absence of obstruction. Those strategies have resulted in reduction of HCM-related morbidity and reduction of mortality to 0.5% per year.PMID:35084989 | DOI:10.1146/annurev-med-042220-021539

Source: Annual Review of Medicine - January 27, 2022 Category: General Medicine Authors: Barry J Maron Ethan J Rowin Martin S Maron Source Type: research