Controlled subretinal injection pressure prevents damage in pigs

Conclusion This study indicates that an injection pressure at approximately 24 PSI might be safe for subretinal delievery. Retinal damage at low injection pressures may be explained by mechanical damage to the RPE due to prolonged needle time in the subretinal space, whilst retinal damage at high pressures can be related to high flow in the injection cannula. Controlled subretinal injection pressure of 24 PSI showed minimum mechanical and flow-related damage to the porcine retina.
Source: Ophthalmologica - Category: Opthalmology Source Type: research