Antineonatal Fc Receptor Antibody Treatment Ameliorates MOG-IgG-Associated Experimental Autoimmune Encephalomyelitis

Discussion
We show preserved optomotor response and ameliorated course of disease after anti-FcRn treatment in an experimental model using a monoclonal MOG-IgG to mimic MOGAD. Selectively targeting FcRn might represent a promising therapeutic approach in MOGAD.

Source: Neurology Neuroimmunology and Neuroinflammation - January 13, 2022 Category: Neurology Authors: Remlinger, J., Madarasz, A., Guse, K., Hoepner, R., Bagnoud, M., Meli, I., Feil, M., Abegg, M., Linington, C., Shock, A., Boroojerdi, B., Kiessling, P., Smith, B., Enzmann, V., Chan, A., Salmen, A. Tags: Optic nerve, Retina Article Source Type: research