Phenformin increases early hematopoietic progenitors in the Jak2V617F murine model

Conclusions. Phenformin increased the percentages of LSK, MP, and MPP populations, but did not reduce disease burden in Jak2V617F-knockin mice. Additional studies are necessary to further understand the effects of phenformin on early hematopoietic progenitors.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research