Association between gene polymorphism and adverse effects in cancer patients receiving docetaxel treatment: a meta-analysis

ConclusionAn association between the ABCB1 C3435T (rs1045642), ABCB1 G2677T/A (rs2032582) polymorphism and risk of adverse effects of docetaxel was found by our meta-analysis. Namely, the TT homozygotes of the ABCB1 C3435T polymorphism may be associated with the risk of hematological toxicity. ABCB1 G2677T T(A)/T(A) genotype may be associated with the fluid retention.Trail registrationPROSPERO 2020 CRD42020203132.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research