Opportunities for Drug Repurposing of Serotonin Reuptake Inhibitors: Potential Uses in Inflammation, Infection, Cancer, Neuroprotection, and Alzheimer ’s Disease Prevention
Pharmacopsychiatry DOI: 10.1055/a-1686-9620Serotonin reuptake inhibitors (SRIs) are safe and widely used for a variety of
indications including depressive disorders, anxiety, and chronic pain. Besides
inhibiting the serotonin transporter, these medications have broad-spectrum
properties in many systems. Their roles have been studied in cancer,
Alzheimer’s disease, and infectious processes. The COVID-19 pandemic
highlighted the importance of drug repurposing of medications already in use. We
conducted a narrative review of current evidence and ongoing research on drug
repurposing of SRIs, with a focus on immunomodulatory, antiproliferative, and
neuroprotective activity. SRIs may have clinical use as repurposed agents for a
wide variety of conditions including but not limited to COVID-19,
Alzheimer’s disease, and neoplastic processes. Further research,
particularly randomized controlled trials, will be necessary to confirm the
utility of SRIs for new indications. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Pharmacopsychiatry - Category: Psychiatry Authors: Nykamp, Madeline J. Zorumski, Charles F. Reiersen, Angela M. Nicol, Ginger E. Cirrito, John Lenze, Eric J. Tags: Review Source Type: research
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