Is there a link between autophagy, sarcoidosis, and non granulomatous neurological disorders?

Introduction: Previous genomic studies suggested that impaired autophagy could promote sarcoidosis (Pacheco et al. Trends Immunol 2020; 41: 286–299). Autophagy can be altered in nongranulomatous neurological disorders (NGND) such as frontotemporal dementia (FTD) or Parkinson’s disease (PD) in which the accumulation of proteins such as α-synuclein due to an mitophagy defect had been suggested.Methods: We performed a whole exome sequencing (WES) study of sarcoidosic patients in the SARCFAM (familial sarcoidosis) cohort (familial sarcoidosis). In order to distinguish potentially pathogenic variants, a genomic subtraction with internal controls among siblings in each family was performed.Results: We focused on seven patients with NGND and sarcoidosis association out of the SARCFAM cohort (Calender et al. Eur Respir J 2019; 54). Patients were experiencing various NGND such as neurodegenerative (FTD, PD) or inflammatory disorders (encephalomyelitis). Accumulation of rare (minor allele frequency
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD / DPLD Source Type: research

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Source: European Radiology - Category: Radiology Source Type: research
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Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Dementia Sleep Source Type: blogs
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Source: - Category: Research Source Type: clinical trials
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Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Life digital wisdom Source Type: news
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Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Hysteria flash fiction hysteria 2021 hysteria 8 Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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