Is there a link between autophagy, sarcoidosis, and non granulomatous neurological disorders?
Introduction: Previous genomic studies suggested that impaired autophagy could promote sarcoidosis (Pacheco et al. Trends Immunol 2020; 41: 286–299). Autophagy can be altered in nongranulomatous neurological disorders (NGND) such as frontotemporal dementia (FTD) or Parkinson’s disease (PD) in which the accumulation of proteins such as α-synuclein due to an mitophagy defect had been suggested.Methods: We performed a whole exome sequencing (WES) study of sarcoidosic patients in the SARCFAM (familial sarcoidosis) cohort (familial sarcoidosis). In order to distinguish potentially pathogenic variants, a genomic subtraction with internal controls among siblings in each family was performed.Results: We focused on seven patients with NGND and sarcoidosis association out of the SARCFAM cohort (Calender et al. Eur Respir J 2019; 54). Patients were experiencing various NGND such as neurodegenerative (FTD, PD) or inflammatory disorders (encephalomyelitis). Accumulation of rare (minor allele frequency
A Correction to this paper has been published:https://doi.org/10.1007/s00330-021-07757-5
Normal-pressure hydrocephalus (NPH) is characterized by the clinical triad of dementia, gait instability, and urinary incontinence. The estimated annual incidence is 1.8 cases in 100,000 persons, making NPH a rare diagnosis and uncommon cause of dementia. NPH is a form of communicating hydrocephalus that can easily be missed in older adults with multiple comorbidities, so clinicians must exclude reversible causes of dementia before diagnosing irreversible causes such as Alzheimer disease.
On your side, face-up or face-down? The position which best clears metabolic waste from your brain at night.
Nine years before memory changes, this can signal problems.
Condition: Parkinson Disease Intervention: Other: This is an observational study, there is no intervention in this study. Sponsors: University of Haifa; Rambam Health Care Campus Active, not recruiting
Condition: Parkinson Disease Intervention: Other: Smart-home for freezing of gait Sponsors: University of Haifa; Hebrew University of Jerusalem; Technion, Israel Institute of Technology Recruiting
I still remember the Christmas my sister was given one of the very first computer games as a gift from our parents. Plugged into our television it allowed us to play a virtual game of tennis, batting what I now know to be a collection of pixels against the sides of the screen, so it bounced randomly around. I must have been about 11 at the time and I still recall the recognition that something fundamental had changed about the world I lived in, although it was to be several decades later that I was able to articulate it in a way that made sense. That Christmas morning was a turning point; not just for me, but for all human...
Abdulrahman Mohammed Abu-Yaman is the winner of the flash fiction category in the 2021 Hysteria Writing Competition. You can find his writing, along with the other finalists from each category in the Hysteria 8 anthology. Listen to the recording Read by Steve Graham during the Hysteria 8 launch party. https://lindaph.co.uk/wp-content/uploads/2022/01/Abdulrahman-Mohammed-Abu-Yaman.mp3 Read his entry Civilization begins in Egypt—our dear mother. Cairo, her cherub son, lounges atop the pyramid—on the spot where all the vertical borders intersect. Oriental Asia welcomes the sunrise. The sunshine flashes the limel...
THURSDAY, Jan. 27, 2022 -- Red wine may be a guilty pleasure, but new research shows it might also be a powerful weapon against the ravages of Parkinson's disease. Why? The antioxidants in red wine, and fruit such as berries for that matter, might...
DEMENTIA has more than 200 different subtypes. Research into the conditions is ongoing, though some studies suggest that there are foods to limit.